Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
COPS3 [nucleoplasm]
Stable Identifier
R-HSA-5697017
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
COP9 signalosome complex subunit 3, CSN3_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS3 [nucleoplasm] (Homo sapiens)
UV-DDB:COP9 Signalosome [nucleoplasm] (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS3 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS3 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS3 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UNS2 COPS3
Gene Names
COPS3, CSN3
Chain
initiator methionine:, chain:2-423
Reference Genes
BioGPS Gene:8533 COPS3
COSMIC (genes):COPS3 COPS3
CTD Gene:8533 COPS3
dbSNP Gene:8533 COPS3
ENSEMBL:ENSG00000141030 COPS3
ENSEMBL_homo_sapiens_GENE:ENSG00000141030.13 COPS3
HGNC:2239 COPS3
KEGG Gene (Homo sapiens):8533 COPS3
Monarch:8533 COPS3
NCBI Gene:8533 COPS3
OMIM:604665 COPS3
UCSC:Q9UNS2 COPS3
Reference Transcript
RefSeq:NM_001199125.1 COPS3
RefSeq:NM_001316355.1 COPS3
RefSeq:NM_001316354.1 COPS3
RefSeq:NM_001316357.1 COPS3
RefSeq:NM_001316356.1 COPS3
RefSeq:NM_003653.3 COPS3
RefSeq:NM_001316358.1 COPS3
RefSeq:XM_005256837.4 COPS3
Other Identifiers
11757601_a_at
16841885
202078_PM_at
202078_at
35349_at
3747718
3747719
3747720
3747721
3747725
3747727
3747728
3747730
3747734
3747735
3747736
3747740
3747742
3747743
3747744
3747745
3747746
8013094
8533
A_23_P89199
GE54246
GO:0000338
GO:0001701
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006511
GO:0007165
GO:0008180
GO:0009416
GO:0023052
GO:0030163
GO:0032991
GO:0036211
GO:0043226
GO:0045116
GO:0048471
GO:0048856
GO:1902162
GO:2000434
HMNXSV003018891
HMNXSV003031923
ILMN_1770732
PH_hs_0000611
TC17001186.hg
g4502974_3p_at
Participates
as a component of
COP9 signalosome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
COPS3 [cytosol]
Inferred To
CSN3 [nucleoplasm]
(Drosophila melanogaster)
csn3 [nucleoplasm]
(Dictyostelium discoideum)
csn3 [nucleoplasm]
(Schizosaccharomyces pombe)
Cops3 [nucleoplasm]
(Mus musculus)
Cops3 [nucleoplasm]
(Rattus norvegicus)
csn-3 [nucleoplasm]
(Caenorhabditis elegans)
COPS3 [nucleoplasm]
(Bos taurus)
COPS3 [nucleoplasm]
(Canis familiaris)
COPS3 [nucleoplasm]
(Gallus gallus)
COPS3 [nucleoplasm]
(Sus scrofa)
cops3 [nucleoplasm]
(Danio rerio)
cops3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001303286.1
,
NP_001303287.1
,
NP_003644.2
,
NP_001303285.1
,
NP_001186054.1
,
NP_001303283.1
,
NP_001303284.1
,
XP_005256894.1
OpenTargets
ENSG00000141030
GeneCards
Q9UNS2
HPA
ENSG00000141030-COPS3
Ensembl
ENSG00000141030
,
ENSP00000268717
,
ENST00000539941
,
ENST00000268717
,
ENSP00000437606
PRO
Q9UNS2
Pharos - Targets
Q9UNS2
PDB
8H3A
,
4D10
,
6R7N
,
8H3F
,
6R6H
,
8H38
,
4WSN
,
6R7H
,
4D18
,
6R7I
,
6R7F
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.725
4
UniProt:O14832 PHYH
4
PHYH [peroxisomal matrix]
(R-HSA-389574)
PHYH(1-338) [cytosol]
(R-HSA-9033143)
PHYH(1-338) [peroxisomal matrix]
(R-HSA-9033535)
PHYH(1-30) [peroxisomal matrix]
(R-HSA-9033518)
0.675
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
22
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.581
3
UniProt:P35240 NF2
1
NF2 [plasma membrane]
(R-HSA-5669168)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:O43559 FRS3
3
p-5Y-FRS3 [plasma membrane]
(R-HSA-191475)
FRS3 [plasma membrane]
(R-HSA-191482)
p-Y-FRS3 [plasma membrane]
(R-HSA-9032427)
0.556
3
UniProt:Q8TBF2 PRXL2B
1
FAM213B [cytosol]
(R-HSA-2142703)
0.556
5
UniProt:P02545-2 LMNA
5
LMNA-2 [nuclear envelope]
(R-HSA-912378)
p-S22, S395-LMNA-2 [nucleoplasm]
(R-HSA-5229019)
p-S395-LMNA-2 [nucleoplasm]
(R-HSA-5228740)
Lamin C [nucleoplasm]
(R-HSA-264872)
LMNA-2 [cytosol]
(R-HSA-2995387)
0.556
3
UniProt:Q16143 SNCB
1
SNCB [cytosol]
(R-HSA-5660390)
0.556
3
UniProt:P51149 RAB7A
7
RAB7A [secretory granule membrane]
(R-HSA-6804969)
RAB7A [plasma membrane]
(R-HSA-6804990)
RAB7A [cytosol]
(R-HSA-8870415)
RAB7A [phagocytic vesicle membrane]
(R-HSA-9636586)
RAB7A [lysosomal membrane]
(R-HSA-2213231)
GGC-RAB7A [cytosol]
(R-HSA-8870438)
GGC-RAB7A [lysosomal membrane]
(R-HSA-8877454)
0.556
3
UniProt:P29474 NOS3
9
2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane]
(R-HSA-9860783)
2xPalmC-MyrG-p-S633-NOS3 [plasma membrane]
(R-HSA-9861341)
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
NOS3 [cytosol]
(R-HSA-202114)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:P68871 HBB
8
CO-H+-HBB [cytosol]
(R-HSA-1237013)
HBB [ficolin-1-rich granule lumen]
(R-HSA-6801015)
HBB [tertiary granule lumen]
(R-HSA-6800191)
HBB [endocytic vesicle lumen]
(R-HSA-2230936)
HBB [extracellular region]
(R-HSA-2168872)
HBB [late endosome lumen]
(R-HSA-9631108)
HBB [cytosol]
(R-HSA-1008196)
HBB [lysosomal lumen]
(R-HSA-9625193)
0.527
2
UniProt:Q92466 DDB2
3
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
DDB2 [nucleoplasm]
(R-HSA-53491)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
0.527
3
UniProt:Q9UKA1 FBXL5
1
FBXL5 [cytosol]
(R-HSA-391295)
0.527
2
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.508
2
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.462
6
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text