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CASP3(1-277) [cytosol]
Stable Identifier
R-HSA-57021
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Caspase-3 precursor, Apopain precursor , Cysteine protease CPP32, Yama protein, CPP-32, CASP-3, SREBP cleavage activity 1, SCA-1
Icon
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)
Activation of caspase-3 (Homo sapiens)
CASP3(1-277) dimer [cytosol] (Homo sapiens)
CASP3(1-277) [cytosol] (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
Cytochrome c-mediated apoptotic response (Homo sapiens)
Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)
Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)
CASP3(1-277) dimer [cytosol] (Homo sapiens)
CASP3(1-277) [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NADE modulates death signalling (Homo sapiens)
p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)
Procaspases 2, 3 [cytosol] (Homo sapiens)
CASP3(1-277) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42574 CASP3
Gene Names
CASP3, CPP32
Chain
propeptide:1-9, propeptide:10-28, chain:29-175, chain:176-277
Reference Genes
BioGPS Gene:836 CASP3
COSMIC (genes):CASP3 CASP3
CTD Gene:836 CASP3
dbSNP Gene:836 CASP3
ENSEMBL:ENSG00000164305 CASP3
ENSEMBL_homo_sapiens_GENE:ENSG00000164305.20 CASP3
HGNC:1504 CASP3
KEGG Gene (Homo sapiens):836 CASP3
Monarch:836 CASP3
NCBI Gene:836 CASP3
OMIM:600636 CASP3
UCSC:P42574 CASP3
Reference Transcript
RefSeq:NM_032991.2 CASP3
RefSeq:NM_004346.3 CASP3
RefSeq:XM_011532301.1 CASP3
Other Identifiers
11717805_a_at
11719838_a_at
11719839_a_at
16982011
202763_PM_at
202763_at
2796488
2796489
2796490
2796491
2796492
2796494
2796495
2796496
2796497
2796500
2796502
2796504
2796505
2796506
2796507
36143_at
8103922
836
A_23_P92410
A_33_P3278118
GE58946
GO:0001554
GO:0001666
GO:0001782
GO:0001818
GO:0002020
GO:0002376
GO:0003824
GO:0004175
GO:0004190
GO:0004197
GO:0004861
GO:0005123
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006508
GO:0006914
GO:0006915
GO:0006974
GO:0007155
GO:0007413
GO:0007507
GO:0007605
GO:0007611
GO:0008233
GO:0008234
GO:0008627
GO:0009410
GO:0009411
GO:0009611
GO:0009749
GO:0010033
GO:0010038
GO:0010165
GO:0012501
GO:0014070
GO:0016005
GO:0016241
GO:0016485
GO:0016787
GO:0021766
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030182
GO:0030216
GO:0030218
GO:0030220
GO:0030889
GO:0031264
GO:0031647
GO:0032025
GO:0032355
GO:0032496
GO:0034349
GO:0034612
GO:0035094
GO:0035556
GO:0036211
GO:0042542
GO:0043025
GO:0043029
GO:0043065
GO:0043200
GO:0043226
GO:0043525
GO:0044346
GO:0044877
GO:0045165
GO:0045786
GO:0046007
GO:0048011
GO:0048856
GO:0050877
GO:0051146
GO:0051384
GO:0051402
GO:0051604
GO:0051716
GO:0061713
GO:0070269
GO:0071310
GO:0071407
GO:0071887
GO:0072734
GO:0097153
GO:0097190
GO:0097193
GO:0097194
GO:0097199
GO:0097200
GO:0098772
GO:0140096
GO:0140639
GO:1902004
GO:1904019
HMNXSV003052694
ILMN_1731639
ILMN_2388155
PH_hs_0022563
TC04001807.hg
U13737_at
g4757911_3p_at
Participates
as a member of
Procaspases 2, 3 [cytosol] (Homo sapiens)
as a component of
CASP3(1-277) dimer [cytosol] (Homo sapiens)
Other forms of this molecule
CASP3(29-175) [nucleoplasm]
CASP3(176-277) [nucleoplasm]
CASP3(29-175) [cytosol]
CASP3(176-277) [cytosol]
Inferred To
Drice [cytosol]
(Drosophila melanogaster)
CASP3 [cytosol]
(Bos taurus)
CASP3 [cytosol]
(Canis familiaris)
CASP3 [cytosol]
(Gallus gallus)
Casp3 [cytosol]
(Mus musculus)
Casp3 [cytosol]
(Rattus norvegicus)
CASP3(1-277) [cytosol]
(Sus scrofa)
casp3.2 [cytosol]
(Xenopus tropicalis)
casp3a [cytosol]
(Danio rerio)
ced-3 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_116786.1
,
NP_004337.2
,
XP_011530603.1
ZINC - World Drugs
CASP3_HUMAN
Guide to Pharmacology - Targets
1619
OpenTargets
ENSG00000164305
ZINC - FDA approved
CASP3_HUMAN
ZINC - Substances
CASP3_HUMAN
ZINC - Biogenic
CASP3_HUMAN
ZINC target
P42574
PRO
P42574
PDB
3ITN
,
2CNN
,
5I9B
,
4QU9
,
4QUH
,
2Y0B
,
1CP3
,
5IAR
,
2XZT
,
4JR0
,
4JQY
,
3EDQ
,
7XN5
,
4PRY
,
5IAK
,
4QUB
,
3PCX
,
1RE1
,
5IBC
,
4QUJ
,
1NMS
,
5IAB
,
2XYP
,
3GJS
,
4QU5
,
4EHN
,
4QTY
,
4EHK
,
5IC4
,
4DCP
,
3DEH
,
2C1E
,
3DEJ
,
2C2O
,
3GJQ
,
2CNL
,
2CJX
,
2C2K
,
2J32
,
4PS0
,
2XYG
,
4EHF
,
5IAG
,
2J30
,
3PD1
,
3KJF
,
2H5J
,
4EHA
,
1NME
,
5IAS
,
4QUI
,
2CNO
,
4QU8
,
1RHR
,
2DKO
,
4QUG
,
2CDR
,
4JQZ
,
1RHU
,
5IAN
,
5IBP
,
7XN6
,
4QUD
,
4DCJ
,
1GFW
,
5IAJ
,
5I9T
,
7XN4
,
1NMQ
,
4QUA
,
2H5I
,
4QUL
,
3PD0
,
1I3O
,
3GJT
,
3DEK
,
4JJE
,
4EHL
,
1PAU
,
4QU0
,
2CNK
,
3DEI
,
4DCO
,
3GJR
,
2C2M
,
4QUE
,
2CJY
,
5IBR
,
4QTX
,
4EHH
,
1RHM
,
1QX3
,
2J33
,
1RHQ
,
2XYH
,
2H65
,
2J31
,
2XZD
,
1RHJ
,
3H0E
,
4EHD
,
5IAE
,
1RHK
ZINC - Investigational
CASP3_HUMAN
IntEnz
3.4.22.56
GeneCards
P42574
HPA
ENSG00000164305-CASP3
Ensembl
ENSP00000311032
,
ENST00000700100
,
ENST00000700101
,
ENST00000523916
,
ENSP00000428929
,
ENSG00000164305
,
ENSP00000514797
,
ENST00000308394
,
ENSP00000514798
Pharos - Targets
P42574
ZINC - Predictions - Purchasable
CASP3_HUMAN
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.872
7
UniProt:P10599 TXN
4
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.672
6
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.659
4
UniProt:O14727 APAF1
4
APAF1 [secretory granule lumen]
(R-HSA-6801271)
APAF1 [extracellular region]
(R-HSA-6806465)
APAF1 [ficolin-1-rich granule lumen]
(R-HSA-6801301)
APAF1 [cytosol]
(R-HSA-50099)
0.653
7
UniProt:P55211 CASP9
5
p-S196-CASP9(1-416) [cytosol]
(R-HSA-198636)
p-T412-CASP9(1-416) [cytosol]
(R-HSA-9627087)
CASP9(331-416) [cytosol]
(R-HSA-141639)
CASP9(?-315) [cytosol]
(R-HSA-141638)
CASP9(1-416) [cytosol]
(R-HSA-57033)
0.644
3
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.623
2
UniProt:O60551 NMT2
1
NMT2 [cytosol]
(R-HSA-184377)
0.609
2
UniProt:Q9Y243 AKT3
6
p-T305-AKT3 [cytosol]
(R-HSA-3009370)
AKT3 [cytosol]
(R-HSA-2976007)
AKT3 [plasma membrane]
(R-HSA-2976006)
p-S472-AKT3 [plasma membrane]
(R-HSA-3009363)
p-T305,S472-AKT3 [cytosol]
(R-HSA-3009367)
p-T305,S472-AKT3 [nucleoplasm]
(R-HSA-3009365)
0.571
2
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.571
2
UniProt:P55212 CASP6
5
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
0.571
2
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
9
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
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