Reactome | IMPDH2 [cytosol]

IMPDH2 [cytosol]

Stable Identifier

R-HSA-57350

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IMP (inosine monophosphate) dehydrogenase 2, Inosine-5'-monophosphate dehydrogenase 2 (EC 1.1.1.205) (IMP dehydrogenase 2) (IMPDH-II) (IMPD 2), Inosine-5'-monophosphate dehydrogenase 2 , IMP dehydrogenase 2, IMPDH-II, IMPD 2

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        IMPDH tetramers binds IMPDH inhibitors (Homo sapiens)
        
        IMPDH tetramers [cytosol] (Homo sapiens)
        
        IMPDH2 tetramer [cytosol] (Homo sapiens)
        
        IMPDH2 [cytosol] (Homo sapiens)
        
        IMPDH tetramers:IMPDH inhibitors [cytosol] (Homo sapiens)
        
        IMPDH tetramers [cytosol] (Homo sapiens)
        
        IMPDH2 tetramer [cytosol] (Homo sapiens)
        
        IMPDH2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P12268 IMPDH2

Gene Names

IMPDH2, IMPD2

Chain

initiator methionine:, chain:2-514

Reference Genes

BioGPS Gene:3615 IMPDH2

COSMIC (genes):IMPDH2 IMPDH2

CTD Gene:3615 IMPDH2

dbSNP Gene:3615 IMPDH2

ENSEMBL:ENSG00000178035 IMPDH2

HGNC:6053 IMPDH2

KEGG:hsa:3615 IMPDH2

Monarch:3615 IMPDH2

NCBI Gene:3615 IMPDH2

OMIM:146691 IMPDH2

UCSC:P12268 IMPDH2

Reference Transcript

RefSeq:NM_000884.2 IMPDH2

Other Identifiers

11740923_a_at

11740924_x_at

11744423_a_at

11752369_a_at

11752370_x_at

11757427_x_at

16953813

201892_PM_s_at

201892_s_at

2673874

2673875

2673876

2673877

2673878

2673879

2673880

2673881

2673882

2673883

2673884

2673885

2673886

2673887

2673888

2673889

2673890

2673891

2673892

2673893

2673894

2673895

2673896

2673897

2673898

2673899

2673900

2673901

3615

36624_at

8087254

A_24_P166042

A_33_P3214298

GE57726

GE86796

GO:0000166

GO:0002376

GO:0003677

GO:0003723

GO:0003824

GO:0003938

GO:0005515

GO:0005576

GO:0005634

GO:0005737

GO:0005778

GO:0005829

GO:0006164

GO:0006177

GO:0006183

GO:0007623

GO:0016020

GO:0016491

GO:0034774

GO:0043226

GO:0046651

GO:0046872

GO:0055086

GO:0070062

GO:0071353

GO:0097294

GO:1901135

GO:1904813

HMNXSV003008658

ILMN_1705737

L33842_rna1_at

PH_hs_0004326

PH_hs_0035456

TC03001397.hg

g4504688_3p_s_at

Participates

as a component of

IMPDH2 tetramer [cytosol] (Homo sapiens)

Other forms of this molecule

IMPDH2 [secretory granule lumen]

IMPDH2 [extracellular region]

IMPDH2 [ficolin-1-rich granule lumen]

Inferred To

IMPDH1 [cytosol] (Caenorhabditis elegans)

IMPDH1 [cytosol] (Dictyostelium discoideum)

IMPDH1 [cytosol] (Drosophila melanogaster)

IMPDH1 [cytosol] (Plasmodium falciparum)

IMPDH1 [cytosol] (Saccharomyces cerevisiae)

IMPDH1 [cytosol] (Schizosaccharomyces pombe)

IMPDH2 [cytosol] (Bos taurus)

IMPDH2 [cytosol] (Canis familiaris)

IMPDH2 [cytosol] (Danio rerio)

IMPDH2 [cytosol] (Gallus gallus)

IMPDH2 [cytosol] (Mus musculus)

IMPDH2 [cytosol] (Rattus norvegicus)

IMPDH2 [cytosol] (Sus scrofa)

Cross References

ZINC - World Drugs

IMDH2_HUMAN

Guide to Pharmacology - Targets

2625

OpenTargets

ENSG00000178035

ENSEMBL

ENST00000326739, ENSP00000321584

ZINC - FDA approved

IMDH2_HUMAN

ZINC - Substances

IMDH2_HUMAN

ZINC - Biogenic

IMDH2_HUMAN

ZINC target

P12268

PRO

P12268

GlyGen

P12268

PDB

1NFB, 1B3O, 1NF7, 6I0M, 6UA2, 6UAJ, 8G9B, 6U8R, 6UDO, 6UDP, 8FUZ, 6I0O, 6UA5, 6U8S, 6UA4, 8FOZ, 6U8E, 6UDQ, 8G8F, 6U8N, 6U9O, 6UC2

IntEnz

1.1.1.205

HPA

ENSG00000178035-IMPDH2

Pharos - Targets

P12268

ZINC - Predictions - Purchasable

IMDH2_HUMAN

HMDB Protein

HMDBP00881

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.556	3
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.556	3
UniProt:Q8WWZ1 IL1F10	3	IL1F10(1-?) [extracellular region] (R-HSA-9007899) IL1F10(?-152) [extracellular region] (R-HSA-9007903) IL1F10 [extracellular region] (R-HSA-8863045)	0.556	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:Q96H78 SLC25A44	1	SLC25A44 [mitochondrial inner membrane] (R-HSA-9672776)	0.527	2
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11
UniProt:P0DTC4 E	9	Ub-3xPalmC-E [virion membrane] (R-COV-9698416) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754)	0.482	2

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