IRS2 [cytosol]

Stable Identifier
R-HSA-57528
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Insulin receptor substrate-2, IRS-2
Icon
IRS2 [cytosol] icon
IRS2 [cytosol] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
9553137 Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells

Lienhard, GE, Fantin, VR, Keller, SR, Sparling, JD, Lavan, BE, Slot, JW

J. Biol. Chem. 1998
9852124 Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling

Feldman, EL, Cheng, HL, Margolis, B, Kim, B

J. Biol. Chem. 1998
External Reference Information
External Reference
UniProt:Q9Y4H2 IRS2
Gene Names
IRS2
Chain
chain:1-1338
Reference Genes
BioGPS Gene:8660 IRS2
COSMIC (genes):IRS2 IRS2
CTD Gene:8660 IRS2
dbSNP Gene:8660 IRS2
ENSEMBL:ENSG00000185950 IRS2
ENSEMBL_homo_sapiens_GENE:ENSG00000185950.9 IRS2
HGNC:6126 IRS2
KEGG Gene (Homo sapiens):8660 IRS2
Monarch:8660 IRS2
NCBI Gene:8660 IRS2
OMIM:600797 IRS2
UCSC:Q9Y4H2 IRS2
Reference Transcript
Other Identifiers
11718012_at
11718013_at
16780917
209184_PM_s_at
209184_s_at
209185_PM_s_at
209185_s_at
3525236
3525237
3525238
3525239
3525240
3525241
3525242
3525243
3525259
3525260
3525261
3525262
3525263
3525264
3525265
3525266
3525267
3525268
3525269
3525270
3525271
3525272
3525273
3525274
3525275
3525276
40180_at
48795_at
56338_at
7972745
8660
A_24_P154037
A_24_P207003
GO:0002053
GO:0002376
GO:0002903
GO:0005068
GO:0005158
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0005975
GO:0006006
GO:0006091
GO:0006629
GO:0007165
GO:0007420
GO:0008283
GO:0008284
GO:0008286
GO:0009749
GO:0010631
GO:0010634
GO:0010748
GO:0010907
GO:0012501
GO:0016477
GO:0019216
GO:0019901
GO:0019903
GO:0019904
GO:0023052
GO:0030674
GO:0030879
GO:0030890
GO:0032000
GO:0032024
GO:0032869
GO:0033673
GO:0043548
GO:0044342
GO:0045725
GO:0046326
GO:0048856
GO:0048870
GO:0051897
GO:0055085
GO:0055088
GO:0060090
GO:0071333
GO:0071889
GO:0141038
GO:1901653
GO:1904692
HMNXSV003028001
Hs.143648.0.S2_3p_a_at
ILMN_2083469
PH_hs_0008458
TC13000871.hg
g4511968_3p_a_at
Participates
as a member of
as an input of
as a component of
Other forms of this molecule
IRS2 [plasma membrane]
p-Y-IRS2 [cytosol]
p-Y-IRS2 [plasma membrane]
Inferred To
LOC100498409 [cytosol] (Xenopus tropicalis)
chico [cytosol] (Drosophila melanogaster)
IRS2 [cytosol] (Bos taurus)
IRS2 [cytosol] (Canis familiaris)
IRS2 [cytosol] (Sus scrofa)
Irs2 [cytosol] (Mus musculus)
Irs2 [cytosol] (Rattus norvegicus)
Cross References
RefSeq
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
PDB
Interactors (11)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P61981 YWHAG  1 0.862 9
 UniProt:P31946 YWHAB  1 0.826 7
 UniProt:P63104 YWHAZ  2 0.816 6
 UniProt:Q04917 YWHAH  1 0.802 8
 UniProt:P27348 YWHAQ  1 0.763 6
 UniProt:P27986 PIK3R1  16 0.688 3
 UniProt:Q96EB6 SIRT1  1 0.589 2
 UniProt:P62258 YWHAE  1 0.569 4
 UniProt:P31947 SFN  1 0.536 4
 UniProt:P06213 INSR  6 0.527 4
 UniProt:Q92569 PIK3R3  2 0.527 2
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