Reactome | ITGA2 [plasma membrane]

ITGA2 [plasma membrane]

Stable Identifier

R-HSA-57562

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Integrin alpha-2, Platelet membrane glycoprotein Ia, GPIa, Collagen receptor, VLA-2 alpha chain, CD49b

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Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- MITF-M-regulated melanocyte development (Homo sapiens)
  - MITF-M-dependent gene expression (Homo sapiens)
    - Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition (Homo sapiens)
      - MITF-M-dependent ITGA2 gene expression (Homo sapiens)
        
        ITGA2 [plasma membrane] (Homo sapiens)
- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - CHL1 interactions (Homo sapiens)
        
        CHL1 interacts with beta1 integrins (Homo sapiens)
        
        CHL1:alpha1beta1/alpha2beta1 integrins [plasma membrane] (Homo sapiens)
        
        Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
        
        ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
        
        ITGA2 [plasma membrane] (Homo sapiens)
        
        Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
        
        ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
        
        ITGA2 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET activates PTK2 signaling (Homo sapiens)
        
        PTK2 binds activated MET (Homo sapiens)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
        
        Integrin alpha2beta1,alpha3beta1 [plasma membrane] (Homo sapiens)
        
        ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
        
        ITGA2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17301 ITGA2

Gene Names

ITGA2, CD49B

Chain

signal peptide:1-29, chain:30-1181

Reference Genes

BioGPS Gene:3673 ITGA2

COSMIC (genes):ITGA2 ITGA2

CTD Gene:3673 ITGA2

dbSNP Gene:3673 ITGA2

ENSEMBL:ENSG00000164171 ITGA2

HGNC:6137 ITGA2

KEGG:hsa:3673 ITGA2

Monarch:3673 ITGA2

NCBI Gene:3673 ITGA2

OMIM:192974 ITGA2

UCSC:P17301 ITGA2

Reference Transcript

RefSeq:NM_002203.3 ITGA2

Other Identifiers

11743617_at

11743618_at

16984689

1978_at

205032_PM_at

205032_at

227314_PM_at

227314_at

2809246

2809247

2809256

2809263

2809268

2809269

2809271

2809272

2809273

2809274

2809275

2809276

2809277

2809278

2809279

2809280

2809281

2809283

2809284

2809285

2809286

2809287

2809290

2809291

2809292

2809294

2809295

2809296

2809297

2809298

2809299

2809301

2809302

2809303

2809304

2809305

3673

41481_at

46919_at

8105267

A_14_P126228

A_23_P70161

A_32_P178800

A_32_P208076

GE62439

GE87545

GO:0001540

GO:0001618

GO:0001666

GO:0002687

GO:0005178

GO:0005515

GO:0005518

GO:0005886

GO:0005925

GO:0006929

GO:0006971

GO:0007155

GO:0007160

GO:0007229

GO:0007565

GO:0007596

GO:0008305

GO:0009410

GO:0009887

GO:0009897

GO:0009986

GO:0010634

GO:0014070

GO:0014075

GO:0014850

GO:0014911

GO:0016020

GO:0022414

GO:0030154

GO:0030198

GO:0030424

GO:0030879

GO:0031346

GO:0031589

GO:0032967

GO:0033591

GO:0033627

GO:0034330

GO:0034666

GO:0038064

GO:0038065

GO:0042995

GO:0043236

GO:0043395

GO:0043589

GO:0043679

GO:0044877

GO:0045178

GO:0045727

GO:0045785

GO:0045987

GO:0046718

GO:0046872

GO:0048041

GO:0048333

GO:0048471

GO:0048661

GO:0048856

GO:0048870

GO:0050927

GO:0050966

GO:0051971

GO:0060089

GO:0060100

GO:0070365

GO:0071107

GO:0071260

GO:0071392

GO:0071407

GO:0098609

GO:0098631

GO:0098639

GO:0098793

HMNXSV003046194

Hs.55168.0.A1_3p_at

ILMN_1665792

M28249_at

PH_hs_0024434

TC05000218.hg

g6006008_3p_at

Participates

as an output of

MITF-M-dependent ITGA2 gene expression (Homo sapiens)

as a component of

ITGA2:ITGB1 [plasma membrane] (Homo sapiens)

Inferred To

Itga2 [plasma membrane] (Rattus norvegicus)

if [plasma membrane] (Drosophila melanogaster)

itga2 [plasma membrane] (Xenopus tropicalis)

pat-2 [plasma membrane] (Caenorhabditis elegans)

ITGA2 [plasma membrane] (Bos taurus)

ITGA2 [plasma membrane] (Canis familiaris)

ITGA2 [plasma membrane] (Gallus gallus)

ITGA2 [plasma membrane] (Mus musculus)

ITGA2 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_002194.2

Guide to Pharmacology - Targets

2440

OpenTargets

ENSG00000164171

ENSEMBL

ENSP00000296585, ENST00000296585

ZINC - Substances

ITA2_HUMAN

ZINC target

P17301

PRO

P17301

GlyGen

P17301

PDB

1DZI, 6ND9, 6NDE, 6NDD, 5THP, 6NDA, 5HJ2, 6ND8, 6NDC, 6NDH, 6NDB, 6NDF, 6NDG, 4BJ3, 1AOX, 1V7P

HPA

ENSG00000164171-ITGA2

Pharos - Targets

P17301

Orphanet

ITGA2

ZINC - Predictions - Purchasable

ITA2_HUMAN

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05556 ITGB1	2	ITGB1 [plasma membrane] (R-HSA-57596) ITGB1 [endosome membrane] (R-HSA-9611157)	0.678	5
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.664	5
UniProt:P35282	3	GGC-RAB21 [early endosome membrane] (R-MMU-8876830) GGC-RAB21 [cytosol] (R-MMU-8873769) RAB21 [cytosol] (R-MMU-8873687)	0.625	7
UniProt:P04512 NSP4			0.591	3
UniProt:P84092 Ap2m1	8	AP2M1 [plasma membrane] (R-RNO-167585) AP2M1 [lysosomal membrane] (R-RNO-196144) AP2M1-2 [endocytic vesicle membrane] (R-RNO-416634) Adaptor Protein 2 mu 1 subunit [plasma membrane] (R-RNO-182057) AP2M1 [cytosol] (R-RNO-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-RNO-2130423) AP2M1 [endolysosome membrane] (R-RNO-6784828) phospho-p-T156 AP2M1 [cytosol] (R-RNO-8856805)	0.558	2
IntAct:EBI-9248941 COLLAGEN			0.558	3
UniProt:P17931 LGALS3	3	LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307) LGALS3 [plasma membrane] (R-HSA-879445) LGALS3 [secretory granule membrane] (R-HSA-6803327)	0.527	3
UniProt:Q6UX41 BTNL8	1	BTNL8 [plasma membrane] (R-HSA-8852007)	0.527	2
UniProt:Q9UBM8 MGAT4C	1	MGAT4C [Golgi membrane] (R-HSA-975907)	0.527	2
UniProt:Q8IW75 SPA12			0.527	2
UniProt:O95968 SG1D1			0.527	2
UniProt:Q401N2 ZACN			0.527	2
UniProt:Q8WW62 TMED6			0.527	2
UniProt:O00214 LEG8			0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	5
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2

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