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AK2 [mitochondrial intermembrane space]
Stable Identifier
R-HSA-57822
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
Synonyms
adenylate kinase 2, Adenylate kinase isoenzyme 2, mitochondrial (EC 2.7.4.3) (ATP-AMP transphosphorylase), Adenylate kinase isoenzyme 2, mitochondrial , ATP-AMP transphosphorylase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
ADP + ADP <=> AMP + ATP [AK2] (Homo sapiens)
AK2 [mitochondrial intermembrane space] (Homo sapiens)
AMP + ATP <=> ADP + ADP [AK2] (Homo sapiens)
AK2 [mitochondrial intermembrane space] (Homo sapiens)
External Reference Information
External Reference
UniProt:P54819 AK2
Gene Names
AK2, ADK2
Chain
chain:1-239, initiator methionine:, chain:2-239
Reference Genes
BioGPS Gene:204 AK2
COSMIC (genes):AK2 AK2
CTD Gene:204 AK2
dbSNP Gene:204 AK2
ENSEMBL:ENSG00000004455 AK2
HGNC:362 AK2
KEGG:hsa:204 AK2
Monarch:204 AK2
NCBI Gene:204 AK2
OMIM:103020 AK2
UCSC:P54819 AK2
Reference Transcript
RefSeq:NM_001319140.1 AK2
RefSeq:NM_001625.3 AK2
RefSeq:NM_001319139.1 AK2
RefSeq:NM_013411.4 AK2
RefSeq:NM_001199199.1 AK2
Other Identifiers
11720320_at
11720321_at
11720322_a_at
11720323_s_at
11733317_s_at
11751675_s_at
11751676_x_at
11760208_at
16684826
204
205996_PM_s_at
205996_s_at
208967_PM_s_at
208967_s_at
212172_PM_at
212172_at
212173_PM_at
212173_at
212174_PM_at
212174_at
212175_PM_s_at
212175_s_at
2405359
2405361
2405363
2405365
2405366
2405367
2405368
2405369
2405370
2405371
2405372
2405373
2405374
2405375
2405376
2405377
2405378
2405379
2405380
2405381
2405382
2405383
2405384
2405385
2405386
2405387
2405388
2405389
2405390
2405391
2405392
2405393
2405394
2405395
2405396
2405397
2405398
2405399
2405400
2405401
2405402
2414984
2414987
2414989
2414991
2414993
2414995
2414997
2547293
40788_at
40789_at
61271_at
7914617
7914628
7916590
89644_at
A_23_P200404
A_24_P179903
A_24_P500891
A_33_P3392580
GE504510
GE61191
GE63071
GE894780
GO:0000166
GO:0003824
GO:0004017
GO:0004550
GO:0005515
GO:0005524
GO:0005737
GO:0005739
GO:0005758
GO:0005929
GO:0006139
GO:0006172
GO:0009117
GO:0009123
GO:0015949
GO:0016301
GO:0016740
GO:0016776
GO:0019205
GO:0036126
GO:0043226
GO:0046033
GO:0046034
GO:0046940
GO:0055086
GO:0070062
GO:0097226
GO:1901135
HMNXSV003001561
HMNXSV003049808
Hs.171811.2.A1_3p_a_at
Hs.171811.2.A2_3p_at
Hs.171811.2.A3_3p_at
Hs.171811.2.A4_3p_at
ILMN_1655645
ILMN_1670542
ILMN_1716053
PH_hs_0012813
PH_hs_0015286
TC01002479.hg
TC01005394.hg
g1209686_3p_a_at
g1209686_3p_x_at
g7524345_3p_a_at
Inferred To
Homologues of AK2 [mitochondrial intermembrane space]
(Plasmodium falciparum)
AKLP2 [mitochondrial intermembrane space]
(Plasmodium falciparum)
AK2 [mitochondrial intermembrane space]
(Bos taurus)
AK2 [mitochondrial intermembrane space]
(Caenorhabditis elegans)
AK2 [mitochondrial intermembrane space]
(Canis familiaris)
AK2 [mitochondrial intermembrane space]
(Danio rerio)
AK2 [mitochondrial intermembrane space]
(Dictyostelium discoideum)
AK2 [mitochondrial intermembrane space]
(Drosophila melanogaster)
AK2 [mitochondrial intermembrane space]
(Gallus gallus)
AK2 [mitochondrial intermembrane space]
(Mus musculus)
AK2 [mitochondrial intermembrane space]
(Plasmodium falciparum)
AK2 [mitochondrial intermembrane space]
(Rattus norvegicus)
AK2 [mitochondrial intermembrane space]
(Saccharomyces cerevisiae)
AK2 [mitochondrial intermembrane space]
(Schizosaccharomyces pombe)
AK2 [mitochondrial intermembrane space]
(Sus scrofa)
AK2 [mitochondrial intermembrane space]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSP00000362548
,
ENST00000672715
,
ENSP00000499935
,
ENST00000373449
OpenTargets
ENSG00000004455
ZINC - Substances
KAD2_HUMAN
ZINC target
P54819
PRO
P54819
GlyGen
P54819
PDB
2C9Y
IntEnz
2.7.4.3
HPA
ENSG00000004455-AK2
Pharos - Targets
P54819
Orphanet
AK2
ZINC - Predictions - Purchasable
KAD2_HUMAN
HMDB Protein
HMDBP04072
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95831 AIFM1
0.569
6
UniProt:P08670 VIM
11
Vimentin [lysosomal lumen]
(R-HSA-9659977)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [late endosome lumen]
(R-HSA-9660019)
VIM [cytosol]
(R-HSA-201600)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
0.556
3
IntAct:EBI-25832841 CCSB
0.556
3
UniProt:P49810 PSEN2
2
PSEN2(298-448) [plasma membrane]
(R-HSA-9013329)
PSEN2(1-297) [plasma membrane]
(R-HSA-201599)
0.556
3
UniProt:P54253 ATX1
0.556
3
UniProt:P16284 PECAM1
5
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
0.556
3
UniProt:A0A6Q8PF08 A0A6Q8PF08
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 [plasma membrane]
(R-HSA-170842)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
0.556
3
UniProt:P17612 PRKACA
4
PRKACA [cytosol]
(R-HSA-57844)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
0.556
3
UniProt:P50454 SERPINH1
1
SERPINH1 [endoplasmic reticulum lumen]
(R-HSA-2127480)
0.556
3
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