Reactome | AK2 [mitochondrial intermembrane space]

AK2 [mitochondrial intermembrane space]

Stable Identifier

R-HSA-57822

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

Synonyms

adenylate kinase 2, Adenylate kinase isoenzyme 2, mitochondrial (EC 2.7.4.3) (ATP-AMP transphosphorylase), Adenylate kinase isoenzyme 2, mitochondrial , ATP-AMP transphosphorylase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P54819 AK2

Gene Names

AK2, ADK2

Chain

initiator methionine:1, chain:1-239, chain:2-239

Reference Genes

BioGPS Gene:204 AK2

COSMIC (genes):AK2 AK2

CTD Gene:204 AK2

dbSNP Gene:204 AK2

ENSEMBL:ENSG00000004455 AK2

ENSEMBL:ENSG00000004455.18 AK2

HGNC:362 AK2

KEGG Gene (Homo sapiens):204 AK2

Monarch:204 AK2

NCBI Gene:204 AK2

OMIM:103020 AK2

UCSC:P54819 AK2

Reference Transcript

Other Identifiers

11720320_at

11720321_at

11720322_a_at

11720323_s_at

11733317_s_at

11751675_s_at

11751676_x_at

16684826

204

205996_PM_s_at

205996_s_at

208967_PM_s_at

208967_s_at

212172_PM_at

212172_at

212173_PM_at

212173_at

212174_PM_at

212174_at

212175_PM_s_at

212175_s_at

2405359

2405361

2405363

2405365

2405366

2405367

2405368

2405369

2405370

2405371

2405372

2405373

2405374

2405375

2405376

2405377

2405378

2405379

2405380

2405381

2405382

2405383

2405386

2405391

2405392

2405394

2405395

2405401

2405402

2414984

2414987

2414989

2414991

2414993

2414995

2414997

2547293

40788_at

40789_at

61271_at

7914617

7916590

A_23_P200404

A_24_P179903

A_24_P500891

A_33_P3392580

GE504510

GE61191

GE63071

GE894780

GO:0000166

GO:0003824

GO:0004017

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005739

GO:0005758

GO:0005929

GO:0006139

GO:0006172

GO:0009117

GO:0009123

GO:0015949

GO:0016301

GO:0016310

GO:0016740

GO:0016776

GO:0019205

GO:0036126

GO:0043226

GO:0046033

GO:0046034

GO:0046940

GO:0055086

GO:0070062

GO:0097226

GO:1901135

HMNXSV003001561

HMNXSV003049808

Hs.171811.2.A1_3p_a_at

Hs.171811.2.A2_3p_at

Hs.171811.2.A3_3p_at

Hs.171811.2.A4_3p_at

ILMN_1655645

ILMN_1670542

ILMN_1716053

PH_hs_0015286

TC01002479.hg

TC01005394.hg

g1209686_3p_a_at

g1209686_3p_x_at

g7524345_3p_a_at

Inferred To

Homologues of AK2 [mitochondrial intermembrane space] (Plasmodium falciparum)

Homologues of AK2 [mitochondrial intermembrane space] (Xenopus tropicalis)

AK2 [mitochondrial intermembrane space] (Bos taurus)

AK2 [mitochondrial intermembrane space] (Caenorhabditis elegans)

AK2 [mitochondrial intermembrane space] (Canis familiaris)

AK2 [mitochondrial intermembrane space] (Danio rerio)

AK2 [mitochondrial intermembrane space] (Dictyostelium discoideum)

AK2 [mitochondrial intermembrane space] (Drosophila melanogaster)

AK2 [mitochondrial intermembrane space] (Gallus gallus)

AK2 [mitochondrial intermembrane space] (Mus musculus)

AK2 [mitochondrial intermembrane space] (Plasmodium falciparum)

AK2 [mitochondrial intermembrane space] (Rattus norvegicus)

AK2 [mitochondrial intermembrane space] (Saccharomyces cerevisiae)

AK2 [mitochondrial intermembrane space] (Schizosaccharomyces pombe)

AK2 [mitochondrial intermembrane space] (Sus scrofa)

AK2 [mitochondrial intermembrane space] (Xenopus tropicalis)

Cross References

RefSeq

NP_001306068.1, NP_001186128.1, NP_001616.1, NP_001306069.1, NP_037543.1

OpenTargets

ENSG00000004455

ZINC target

P54819

PRO

P54819

PDB

2C9Y

IntEnz

2.7.4.3

GeneCards

P54819

HPA

ENSG00000004455-AK2

Ensembl

ENSP00000362548, ENSG00000004455, ENSP00000499935, ENST00000672715, ENST00000373449

Pharos - Targets

P54819

ZINC - Predictions - Purchasable

KAD2_HUMAN

Orphanet

17980

HMDB Protein

HMDBP04072

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-25832841 CCSB			0.556	3
UniProt:D3DTS7 D3DTS7			0.556	3
UniProt:P17612 PRKACA	3	PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:P16284 PECAM1	4	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:P49810 PSEN2	2	PSEN2(1-297) [plasma membrane] (R-HSA-201599) PSEN2(298-448) [plasma membrane] (R-HSA-9013329)	0.556	3

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