Reactome | PRKAR2B [cytosol]

PRKAR2B [cytosol]

Stable Identifier

R-HSA-57842

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cAMP-dependent protein kinase type II-beta regulatory chain

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - cAMP binds PKA tetramer (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
      - cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
        
        cAMP binds PKA tetramer (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        PRKAR2B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P31323 PRKAR2B

Gene Names

PRKAR2B

Chain

chain:1-418

Reference Genes

BioGPS Gene:5577 PRKAR2B

COSMIC (genes):PRKAR2B PRKAR2B

CTD Gene:5577 PRKAR2B

dbSNP Gene:5577 PRKAR2B

ENSEMBL:ENSG00000005249 PRKAR2B

HGNC:9392 PRKAR2B

KEGG:hsa:5577 PRKAR2B

Monarch:5577 PRKAR2B

NCBI Gene:5577 PRKAR2B

OMIM:176912 PRKAR2B

UCSC:P31323 PRKAR2B

Reference Transcript

RefSeq:NM_002736.2 PRKAR2B

Other Identifiers

11730260_a_at

11730261_a_at

17050154

203680_PM_at

203680_at

3018376

3018377

3018378

3018379

3018380

3018388

3018389

3018396

3018399

3018400

3018402

3018403

3018405

3018406

3018407

3018408

3018409

3018410

3018412

3018413

3018414

3018415

3018416

3018417

37221_at

5577

70226_f_at

70228_r_at

8135378

A_23_P42975

A_33_P3304983

GE57918

GO:0001932

GO:0004862

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005886

GO:0005952

GO:0006629

GO:0006631

GO:0007612

GO:0008603

GO:0019901

GO:0019904

GO:0030425

GO:0030552

GO:0031625

GO:0034236

GO:0035556

GO:0043025

GO:0043197

GO:0043198

GO:0043226

GO:0048471

GO:0050804

GO:0050877

GO:0070062

GO:0097332

GO:0097546

GO:0098772

GO:0098794

GO:0098978

GO:0141162

HMNXSV003057478

ILMN_1684850

M31158_at

PH_hs_0004464

TC07000688.hg

g4506064_3p_at

Participates

as a component of

as a member of

PKA regulatory subunit [cytosol] (Homo sapiens)

Other forms of this molecule

PRKAR2B [ciliary base]

Inferred To

PRKAR2B [cytosol] (Canis familiaris)

PRKAR2B [cytosol] (Drosophila melanogaster)

PRKAR2B [cytosol] (Gallus gallus)

PRKAR2B [cytosol] (Rattus norvegicus)

PRKAR2B [cytosol] (Saccharomyces cerevisiae)

PRKAR2B [cytosol] (Schizosaccharomyces pombe)

PRKAR2B [cytosol] (Xenopus tropicalis)

Ghost homologue of PRKAR2B [cytosol] (Bos taurus)

Ghost homologue of PRKAR2B [cytosol] (Mus musculus)

Ghost homologue of PRKAR2B [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_002727.2

Guide to Pharmacology - Targets

1475

ENSEMBL

ENSG00000005249, ENST00000265717, ENSP00000265717

OpenTargets

ENSG00000005249

GeneCards

PRKAR2B

HPA

ENSG00000005249-PRKAR2B

PRO

P31323

Pharos - Targets

P31323

HMDB Protein

HMDBP08139

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.96	18
UniProt:P24588 AKAP5	2	AKAP5 [plasma membrane] (R-HSA-381669) AKAP5 [cytosol] (R-HSA-416331)	0.742	5
UniProt:P13861 PRKAR2A	2	PRKAR2A [cytosol] (R-HSA-57840) PRKAR2A [ciliary base] (R-HSA-5610412)	0.643	4
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.527	3
UniProt:O95076 ALX3	1	ALX3 [nucleoplasm] (R-HSA-9858233)	0.527	2

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