Reactome | PRKACA [cytosol]

PRKACA [cytosol]

Stable Identifier

R-HSA-57844

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PKA C-alpha, cAMP-dependent protein kinase, alpha-catalytic subunit

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Locations in the PathwayBrowser for interactor UniProt:P54252 ATXN3

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External Reference Information

External Reference

UniProt:P17612 PRKACA

Gene Names

PRKACA, PKACA

Chain

initiator methionine:, chain:2-351

Reference Genes

BioGPS Gene:5566 PRKACA

COSMIC (genes):PRKACA PRKACA

CTD Gene:5566 PRKACA

dbSNP Gene:5566 PRKACA

ENSEMBL:ENSG00000072062 PRKACA

ENSEMBL_homo_sapiens_GENE:ENSG00000072062.16 PRKACA

ENSEMBL_homo_sapiens_GENE:ENSG00000288516.1 PRKACA

HGNC:9380 PRKACA

KEGG Gene (Homo sapiens):5566 PRKACA

Monarch:5566 PRKACA

NCBI Gene:5566 PRKACA

OMIM:601639 PRKACA

UCSC:P17612 PRKACA

Reference Transcript

Other Identifiers

11716146_x_at

11735763_a_at

11757881_s_at

16869570

202801_PM_at

202801_at

216234_3p_s_at

216234_PM_s_at

216234_s_at

3852523

3852524

3852525

3852526

3852528

3852530

3852531

3852532

3852533

3852534

3852537

3852541

3852543

3852544

3852546

3852548

3852551

3852552

3852557

3852561

3852562

3852563

438_at

5566

569_g_at

8034762

A_24_P399630

A_24_P408206

GE59698

GO:0000166

GO:0000287

GO:0001669

GO:0001707

GO:0001843

GO:0002027

GO:0003012

GO:0003013

GO:0003014

GO:0003091

GO:0003824

GO:0004672

GO:0004674

GO:0004679

GO:0004691

GO:0004712

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0005930

GO:0005952

GO:0005975

GO:0006091

GO:0006397

GO:0006468

GO:0006611

GO:0006886

GO:0006913

GO:0006914

GO:0007189

GO:0010737

GO:0010881

GO:0016020

GO:0016071

GO:0016241

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0018105

GO:0019221

GO:0019901

GO:0019904

GO:0022414

GO:0023052

GO:0030145

GO:0030154

GO:0030163

GO:0031410

GO:0031514

GO:0031588

GO:0031594

GO:0031625

GO:0032024

GO:0034237

GO:0034330

GO:0034380

GO:0034605

GO:0034704

GO:0035584

GO:0036126

GO:0036211

GO:0042995

GO:0043197

GO:0043226

GO:0043393

GO:0044853

GO:0045667

GO:0045722

GO:0045879

GO:0046827

GO:0048240

GO:0048471

GO:0048856

GO:0050804

GO:0051480

GO:0051604

GO:0051726

GO:0055065

GO:0055085

GO:0055086

GO:0055117

GO:0060314

GO:0061136

GO:0065003

GO:0070062

GO:0070417

GO:0070613

GO:0071333

GO:0071374

GO:0071377

GO:0071872

GO:0086064

GO:0097225

GO:0097546

GO:0098978

GO:0099170

GO:0106310

GO:0140096

GO:1901135

GO:1903779

GO:1904262

GO:1904539

GO:1990044

GO:2000810

HMNXSV003054641

Hs.77271.1.S1_3p_a_at

ILMN_1786195

ILMN_2395314

PH_hs_0022938

TC19001231.hg

X07767_at

g4506054_3p_at

Participates

as a component of

as an input of

DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Homo sapiens)

as a candidate of

Protein kinase A catalytic subunit [cytosol] (Homo sapiens)

as a member of

PKA catalytic subunit [cytosol] (Homo sapiens)

Other forms of this molecule

PRKACA [mitochondrial matrix]

PRKACA [ciliary base]

PRKACA [nucleoplasm]

Inferred To

Prkaca [cytosol] (Mus musculus)

PRKACA [cytosol] (Bos taurus)

PRKACA [cytosol] (Caenorhabditis elegans)

PRKACA [cytosol] (Canis familiaris)

PRKACA [cytosol] (Danio rerio)

PRKACA [cytosol] (Drosophila melanogaster)

PRKACA [cytosol] (Rattus norvegicus)

PRKACA [cytosol] (Saccharomyces cerevisiae)

PRKACA [cytosol] (Schizosaccharomyces pombe)

PRKACA [cytosol] (Sus scrofa)

PRKACA [cytosol] (Xenopus tropicalis)

Ghost homologue of PRKACA [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_001291278.1, NP_002721.1, NP_997401.1

ZINC - World Drugs

KAPCA_HUMAN

Guide to Pharmacology - Targets

1476

OpenTargets

ENSG00000072062

ZINC - FDA approved

KAPCA_HUMAN

ZINC - Substances

KAPCA_HUMAN

ZINC - Biogenic

KAPCA_HUMAN

ZINC target

P17612

PRO

P17612

PDB

6BYS, 5BX7, 5UZK, 3L9M, 5N23, 4WB8, 3L9L, 3NX8, 4WB6, 6BYR, 6FRX, 3L9N, 8FEC, 5BX6, 5J5X, 4WB7, 3OWP, 6C0U, 4UJ1, 3P0M, 6WJF, 3AMB, 6WJG, 3AMA, 3MVJ, 4UJ2, 3AGM, 3VQH, 3POO, 6NO7, 3AGL, 2GU8, 4UJ9, 4AE6, 8X5L, 5IZJ, 8FE5, 4AE9, 5IZF, 3OVV, 8FE2, 4UJB, 4WB5, 6QJ7, 7Y1G, 3OXT, 3OOG, 4UJA

ZINC - Investigational

KAPCA_HUMAN

HPA

ENSG00000072062-PRKACA

GeneCards

P17612

Ensembl

ENST00000673550, ENSP00000500293, ENSP00000466651, ENSP00000499940, ENST00000589994, ENSG00000288516, ENSP00000309591, ENST00000308677, ENST00000672938, ENSG00000072062

Pharos - Targets

P17612

ZINC - Predictions - Purchasable

KAPCA_HUMAN

Orphanet

22913

HMDB Protein

HMDBP01352

Interactors (80)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31323 PRKAR2B	2	PRKAR2B [ciliary base] (R-HSA-5610414) PRKAR2B [cytosol] (R-HSA-57842)	0.96	18
UniProt:P10644 PRKAR1A	4	PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713476) PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713471) PRKAR1A [ciliary base] (R-HSA-5610408) PRKAR1A [cytosol] (R-HSA-57836)	0.958	17
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.89	12
UniProt:Q92667 AKAP1	2	AKAP1 [cytosol] (R-HSA-992752) AKAP1 [mitochondrial outer membrane] (R-HSA-8951815)	0.837	7
UniProt:P13861 PRKAR2A	2	PRKAR2A [cytosol] (R-HSA-57840) PRKAR2A [ciliary base] (R-HSA-5610412)	0.759	4
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.741	7
UniProt:P24588 AKAP5	2	AKAP5 [plasma membrane] (R-HSA-381669) AKAP5 [cytosol] (R-HSA-416331)	0.725	4
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.725	5
UniProt:Q96SN8 CDK5RAP2	1	CDK5RAP2 [cytosol] (R-HSA-380282)	0.725	6
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.725	5
UniProt:P22694 PRKACB	3	PRKACB [ciliary base] (R-HSA-5610404) PRKACB [cytosol] (R-HSA-57846) PRKACB [nucleoplasm] (R-HSA-111937)	0.725	7
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.666	4
UniProt:Q99996 AKAP9	3	AKAP9(1-1118)-BRAF(381-766) fusion [cytosol] (R-HSA-6802267) AKAP9(1-1118)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802514) AKAP9 [cytosol] (R-HSA-380260)	0.643	3
UniProt:Q5VU43 MYOME			0.643	3
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.643	4
UniProt:Q9P0M2 AKA7G			0.643	3
UniProt:Q9Y2D5 PLAK2			0.643	3
UniProt:Q9UKA4 AKA11			0.643	3
UniProt:Q8N6U8 GPR161	2	GPR161 [endocytic vesicle membrane] (R-HSA-5635021) GPR161 [ciliary membrane] (R-HSA-5610373)	0.643	4
UniProt:P59215	1	GNAO1 [plasma membrane] (R-RNO-2997536)	0.591	4
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.59	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	6
UniProt:Q9NQ31 AKIP1			0.581	4
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.581	3
UniProt:Q9Y2B9 IPKG			0.564	2
UniProt:P35520 CBS	1	PXLP-K119-CBS [cytosol] (R-HSA-1614563)	0.556	3
UniProt:Q969W3 VCF1			0.556	3
UniProt:Q3SY56 SP6			0.556	3
UniProt:O14494 PLPP1	1	PLPP1 [plasma membrane] (R-HSA-76106)	0.556	3
UniProt:O14531 DPYSL4	3	p-Y-DPYSL4 [cytosol] (R-HSA-399794) DPYSL4 [cytosol] (R-HSA-398126) p-S544-DPYSL4 [cytosol] (R-HSA-399808)	0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q9UHP3 USP25	1	USP25 [cytosol] (R-HSA-5696900)	0.556	3
UniProt:P06756 ITGAV	3	ITGAV(31-1048) [specific granule membrane] (R-HSA-6806145) ITGAV(31-1048) [phagocytic vesicle] (R-HSA-1236773) ITGAV(31-1048) [plasma membrane] (R-HSA-210013)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:O60784-2 TOM1			0.556	3
UniProt:P26378-2 P263782			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:Q8NE08 Q8NE08			0.556	3
UniProt:Q4VBR4 Q4VBR4			0.556	3
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.556	3
UniProt:Q5T686 AVPI1			0.556	3
UniProt:Q16560-2 SNRNP35			0.556	3
UniProt:P54819 AK2	1	AK2 [mitochondrial intermembrane space] (R-HSA-57822)	0.556	3
UniProt:O75874 IDH1	10	IDH1 R132H mutant [cytosol] (R-HSA-880015) IDH1 R132L mutant [cytosol] (R-HSA-880000) IDH1 R132S mutant [cytosol] (R-HSA-880048) IDH1 R132C mutant [cytosol] (R-HSA-880031) IDH1 [secretory granule lumen] (R-HSA-6800980) IDH1 [ficolin-1-rich granule lumen] (R-HSA-6800977) IDH1 [extracellular region] (R-HSA-6806433) IDH1 [tertiary granule lumen] (R-HSA-6800163) IDH1 [cytosol] (R-HSA-389549) IDH1 [peroxisomal matrix] (R-HSA-389546)	0.556	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.556	3
UniProt:P23276 KEL	1	KEL [plasma membrane] (R-HSA-5694121)	0.556	3
UniProt:Q9Y228 T3JAM			0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:Q16549 PCSK7			0.556	3
UniProt:Q9C010-2 PKIB			0.556	3
UniProt:Q99720-4 SIGMAR1			0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.556	3
UniProt:Q13387-4 MAPK8IP2			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P23560-2 BDNF			0.556	3
UniProt:P00491 PNP	7	PNP R234P [cytosol] (R-HSA-9735772) PNP E89K [cytosol] (R-HSA-9735781) PNP D128G [cytosol] (R-HSA-9735785) PNP [secretory granule lumen] (R-HSA-6803318) PNP [extracellular region] (R-HSA-6806505) PNP [ficolin-1-rich granule lumen] (R-HSA-6803278) PNP [cytosol] (R-HSA-61933)	0.556	3
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.556	3
IntAct:EBI-25834291 CCSB			0.556	3
UniProt:P21246 PTN	1	PTN [extracellular region] (R-HSA-201500)	0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.556	3
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.556	3
UniProt:P15036 ETS2	2	p-T72-ETS2 [nucleoplasm] (R-HSA-3132735) ETS2 [nucleoplasm] (R-HSA-1629811)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.556	3
UniProt:Q9HC16 APOBEC3G			0.544	6
UniProt:Q13946 PDE7A	1	PDE7A [cytosol] (R-HSA-418525)	0.527	2
UniProt:P0DTD1-PRO_0000449630 REP			0.527	2
UniProt:P61925 IPKA			0.527	2
UniProt:Q9Y463 DYR1B			0.527	2
UniProt:P63167 DYNLL1	6	DYNLL1 [ciliary tip] (R-HSA-5625335) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [cytosol] (R-HSA-387105)	0.527	2
UniProt:P22612 PRKACG	3	PRKACG [ciliary base] (R-HSA-5610405) PRKACG [cytosol] (R-HSA-57848) PRKACG [nucleoplasm] (R-HSA-111938)	0.527	2
UniProt:P12369 Prkar2b	3	cAMP-dependent protein kinase type II-beta regulatory subunit [cytosol] (R-RNO-446975) PRKAR2B [ciliary base] (R-RNO-5610414) PRKAR2B [cytosol] (R-RNO-57842)	0.499	2
UniProt:Q9GZX7 AICDA	1	AICDA [nucleoplasm] (R-HSA-452477)	0.499	3
UniProt:P46108-2 CRK			0.488	2

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