Reactome | PRKCA [cytosol]

PRKCA [cytosol]

Stable Identifier

R-HSA-58196

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein kinase C, alpha type , PKC-alpha, PKC-A

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Locations in the PathwayBrowser for interactor UniProt:P56693 SOX10

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Literature References

PubMed ID	Title	Journal	Year
9588823	Resting distribution and stimulated translocation of protein kinase C isoforms alpha, epsilon and zeta in response to bradykinin and TNF in human endothelial cells Ross, D, Joyner, WL	Endothelium	1997

External Reference Information

External Reference

UniProt:P17252 PRKCA

Gene Names

PRKCA, PKCA, PRKACA

Chain

initiator methionine:, chain:2-672

Reference Genes

BioGPS Gene:5578 PRKCA

COSMIC (genes):PRKCA PRKCA

CTD Gene:5578 PRKCA

dbSNP Gene:5578 PRKCA

ENSEMBL:ENSG00000154229 PRKCA

ENSEMBL_homo_sapiens_GENE:ENSG00000154229.12 PRKCA

HGNC:9393 PRKCA

KEGG Gene (Homo sapiens):5578 PRKCA

Monarch:5578 PRKCA

NCBI Gene:5578 PRKCA

OMIM:176960 PRKCA

UCSC:P17252 PRKCA

Reference Transcript

RefSeq:NM_002737.2 PRKCA

Other Identifiers

11717471_at

11717472_at

11754557_s_at

1437_at

1560074_PM_at

1560074_at

16837128

206923_PM_at

206923_at

213093_PM_at

213093_at

215195_PM_at

215195_at

32304_at

3731827

3731828

3731829

3731830

3731835

3731869

3731902

3731903

3731925

3731926

3731927

3731928

3731958

3731960

3731962

3731963

3731965

3731981

3731986

3731987

3731998

3731999

3732000

3732001

3732002

3732003

3732004

3732005

3732006

3732007

3732008

38042_at

5578

8009301

A_14_P126156

A_23_P55099

A_24_P916496

GE79113

GE86264

GE86266

GO:0000166

GO:0000278

GO:0001525

GO:0001938

GO:0002159

GO:0002376

GO:0003012

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0004698

GO:0005178

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005783

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0006325

GO:0006338

GO:0006468

GO:0006915

GO:0007077

GO:0007155

GO:0008270

GO:0010595

GO:0010613

GO:0012501

GO:0016020

GO:0016071

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0019899

GO:0023052

GO:0030154

GO:0030335

GO:0031666

GO:0031966

GO:0034330

GO:0034351

GO:0035403

GO:0035556

GO:0035866

GO:0036064

GO:0036211

GO:0042060

GO:0043226

GO:0043488

GO:0043536

GO:0043687

GO:0045651

GO:0045766

GO:0045780

GO:0045785

GO:0045931

GO:0046872

GO:0048471

GO:0048856

GO:0048870

GO:0061024

GO:0070062

GO:0070374

GO:0070555

GO:0080090

GO:0090330

GO:0097190

GO:0106071

GO:0106310

GO:0110063

GO:0140096

GO:2000707

HMNXSV003019804

HMNXSV003046285

Hs.279856.0.S1_3p_at

Hs.80206.1.A1_3p_at

Hs2.389532.1.S1_3p_at

ILMN_1771800

PH_hs_0023925

TC17000783.hg

X52479_at

g4506066_3p_at

Participates

as a member of

as a candidate of

Keratinocyte PKCs [cytosol] (Homo sapiens)

as an input of

as a component of

Other forms of this molecule

PRKCA [nucleoplasm]

PRKCA [photoreceptor disc membrane]

pT497,T638,S657-PRKCA [plasma membrane]

p-T497,T638,S657-PRKCA [cytosol]

PRKCA [plasma membrane]

p-T497-PRKCA [cytosol]

p-T497,T638,S657-PRKCA [nucleoplasm]

Inferred To

Homologues of PRKCA [cytosol] (Dictyostelium discoideum)

PRKCA [cytosol] (Caenorhabditis elegans)

PRKCA [cytosol] (Canis familiaris)

PRKCA [cytosol] (Dictyostelium discoideum)

PRKCA [cytosol] (Drosophila melanogaster)

PRKCA [cytosol] (Gallus gallus)

PRKCA [cytosol] (Mus musculus)

PRKCA [cytosol] (Rattus norvegicus)

PRKCA [cytosol] (Saccharomyces cerevisiae)

PRKCA [cytosol] (Schizosaccharomyces pombe)

PRKCA [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_002728.1

ZINC - World Drugs

KPCA_HUMAN

Guide to Pharmacology - Targets

1482

OpenTargets

ENSG00000154229

ZINC - FDA approved

KPCA_HUMAN

ZINC - Substances

KPCA_HUMAN

ZINC target

P17252

ZINC - Biogenic

KPCA_HUMAN

PRO

P17252

PDB

4RA4, 4DNL, 8U37, 3IW4, 2ELI, 8UAK

ZINC - Investigational

KPCA_HUMAN

IntEnz

2.7.11.13

HPA

ENSG00000154229-PRKCA

GeneCards

P17252

Ensembl

ENSG00000154229, ENSP00000408695, ENST00000413366

Pharos - Targets

P17252

ZINC - Predictions - Purchasable

KPCA_HUMAN

HMDB Protein

HMDBP01180

Interactors (82)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05129 PRKCG	1	PRKCG [cytosol] (R-HSA-58204)	0.725	5
UniProt:Q9Y234 LIPT1	1	LIPT1 [mitochondrial matrix] (R-HSA-6792623)	0.666	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.564	2
UniProt:Q9Y5X0 SNX10			0.556	3
UniProt:Q9UJ42 GP160			0.556	3
UniProt:Q9NWS8-3 RMND1			0.556	3
UniProt:O95424 DEXI			0.556	3
UniProt:Q02363 ID2	1	ID2 [nucleoplasm] (R-HSA-452391)	0.556	3
UniProt:P17936 IGFBP3	15	IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3 [extracellular region] (R-HSA-381512) IGFBP3(125-233) [extracellular region] (R-HSA-381465) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(291-187) [extracellular region] (R-HSA-381410) IGFBP3(28-186) [extracellular region] (R-HSA-381454) IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956748) p-IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956963) IGFBP3(28-168) [extracellular region] (R-HSA-381489) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3(169-226) [extracellular region] (R-HSA-381499)	0.556	3
UniProt:Q9BQ24 ZFY21			0.556	3
UniProt:Q15759 MAPK11	4	p-T180,Y182-MAPK11 [nucleoplasm] (R-HSA-198741) MAPK11 [nucleoplasm] (R-HSA-203790) MAPK11 [cytosol] (R-HSA-170989) p-T180,Y182-MAPK11 [cytosol] (R-HSA-171009)	0.556	3
UniProt:P18077 RPL35A	1	RPL35A [cytosol] (R-HSA-72462)	0.556	3
UniProt:Q06481-5 APLP2			0.556	3
UniProt:P51884 LUM	12	LUM [extracellular region] (R-HSA-2466189) N-glycan LUM [Golgi lumen] (R-HSA-2046297) Gal-glycan LUM [Golgi lumen] (R-HSA-2046248) Keratan(1)-LUM [Golgi lumen] (R-HSA-2046316) Keratan(2)-LUM [Golgi lumen] (R-HSA-2046233) Keratan(3)-LUM [Golgi lumen] (R-HSA-2046198) Keratan(4)-LUM [Golgi lumen] (R-HSA-2046205) KS(1)-LUM [Golgi lumen] (R-HSA-2046161) KS(2)-LUM [Golgi lumen] (R-HSA-2046249) KS(2)-LUM [extracellular region] (R-HSA-2046202) KS(2)-LUM [lysosomal lumen] (R-HSA-2046283) LUM [lysosomal lumen] (R-HSA-2104998)	0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
IntAct:EBI-25884997 CCSB			0.556	3
UniProt:Q96NE9-2 FRMD6			0.556	3
UniProt:Q05CR2 Q05CR2			0.556	3
UniProt:P56693 SOX10	2	SOX10 [nucleoplasm] (R-HSA-9613639) p-T240,T244-SOX10 [nucleoplasm] (R-HSA-9824578)	0.556	3
UniProt:Q9ULK6-3 RNF150			0.556	3
UniProt:Q13072 BAGE1			0.556	3
UniProt:Q8NB14 UBP38			0.556	3
UniProt:Q99643 SDHC	1	SDHC [mitochondrial inner membrane] (R-HSA-70988)	0.556	3
UniProt:O95498 VNN2	3	VNN2 [plasma membrane] (R-HSA-2980905) GPI-VNN2 [plasma membrane] (R-HSA-8940753) cleaved GPI-VNN2 [extracellular region] (R-HSA-8941027)	0.556	3
UniProt:Q9UNA4 POLI	1	POLI [nucleoplasm] (R-HSA-5656133)	0.556	3
UniProt:P26951 IL3RA	1	IL3RA [plasma membrane] (R-HSA-879938)	0.556	3
UniProt:Q96FT9-2 IFT43			0.556	3
UniProt:O94844 RHOBTB1	1	RHOBTB1 [endosome membrane] (R-HSA-194899)	0.556	3
UniProt:Q9H8H3 TMT1A	2	METTL7A [extracellular region] (R-HSA-6800468) METTL7A [tertiary granule lumen] (R-HSA-6800170)	0.556	3
UniProt:O15535 ZSC9			0.556	3
UniProt:P43234 CTSO	1	CTSO [lysosomal lumen] (R-HSA-1181227)	0.556	3
UniProt:Q8N983-3 MRPL43			0.556	3
UniProt:Q96A33 CCD47			0.556	3
UniProt:Q8N0Y2-2 ZNF444			0.556	3
UniProt:O14926 FSCN2	1	FSCN2 [cytosol] (R-HSA-9662384)	0.556	3
UniProt:Q2M1J6 Q2M1J6			0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P80192 M3K9			0.556	3
UniProt:Q9H213 MAGH1			0.556	3
UniProt:Q96J88-3 Q96J883			0.556	3
UniProt:Q9BRW5 Q9BRW5			0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:O43598 DNPH1	1	DNPH1 [cytosol] (R-HSA-8953358)	0.556	3
UniProt:Q96LY2-2 Q96LY22			0.556	3
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.556	3
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.556	3
UniProt:P07225 PROS1	8	11xCbxE-PROS1 [platelet alpha granule lumen] (R-HSA-349762) 11xCbxE-PROS1 [extracellular region] (R-HSA-202772) 11xCbxE-PROS1 [plasma membrane] (R-HSA-141004) PROS1(25-676) [endoplasmic reticulum membrane] (R-HSA-159758) 11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane] (R-HSA-159770) 11xCbxE-PROS1(25-676) [Golgi membrane] (R-HSA-159850) PROS1(25-41) [Golgi lumen] (R-HSA-159792) 11xCbxE-PROS1 [Golgi membrane] (R-HSA-159865)	0.556	3
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.556	3
UniProt:Q3YBM2 T176B			0.556	3
UniProt:Q92826 HXB13			0.556	3
UniProt:Q66PJ3-4 ARL6IP4			0.556	3
UniProt:Q3YEC7-3 Q3YEC73			0.556	3
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.556	3
UniProt:P21728 DRD1	1	DRD1 [plasma membrane] (R-HSA-390853)	0.556	3
IntAct:EBI-25876377 CCSB			0.556	3
UniProt:P13051-2 UNG			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:P15169 CPN1	1	CPN1 [extracellular region] (R-HSA-8852824)	0.556	3
UniProt:Q14141 SEPT6			0.556	3
UniProt:Q9BRX2 PELO			0.556	3
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
IntAct:EBI-25857950 CCSB			0.556	3
UniProt:Q6P1J6-2 PLB1			0.556	3
UniProt:Q01105-2 SET			0.556	3
UniProt:A0JLT2-2 MED19			0.556	3
UniProt:P19440-3 P194403			0.556	3
UniProt:Q15027 ACAP1			0.556	3
UniProt:O43761 SNG3			0.556	3
UniProt:Q9Y6X2 PIAS3	1	PIAS3 [nucleoplasm] (R-HSA-2993764)	0.556	3
UniProt:Q8IVH2-2 Q8IVH22			0.556	3
UniProt:P11309-2 PIM1			0.544	2
UniProt:P05771 PRKCB	5	PRKCB [plasma membrane] (R-HSA-156467) PRKCB [cytosol] (R-HSA-58198) p-T500-PRKCB [cytosol] (R-HSA-5218728) p-T500,T642,S661-PRKCB [cytosol] (R-HSA-5218706) p-T500,T642,S661-PRKCB [nucleoplasm] (R-HSA-5223294)	0.527	3
UniProt:Q8NEM2 SHCBP			0.527	2
UniProt:O75319 DUS11			0.527	2
UniProt:P24723 PRKCH	1	PRKCH [cytosol] (R-HSA-58208)	0.527	2
UniProt:Q8N5S1 S2541			0.527	2
UniProt:Q9NQZ5 STARD7	3	pre-STARD7 [mitochondrial intermembrane space] (R-HSA-9839780) cytosolic STARD7 [mitochondrial outer membrane] (R-HSA-9856506) mito-STARD7 [mitochondrial outer membrane] (R-HSA-8873841)	0.527	2
UniProt:Q96M96 FGD4	1	FGD4 [cytosol] (R-HSA-3000215)	0.527	2
UniProt:P48507 GCLM	1	GCLM [cytosol] (R-HSA-174356)	0.527	3
UniProt:P34901 Sdc4	20	Sdc4 [plasma membrane] (R-RNO-2750170) Sdc4 [lysosomal lumen] (R-RNO-2090041) Sdc4 [lysosomal lumen] (R-RNO-2090058) Sdc4 [Golgi lumen] (R-RNO-2076434) Sdc4 [Golgi lumen] (R-RNO-2076411) Sdc4 [Golgi lumen] (R-RNO-2076418) Sdc4 [Golgi lumen] (R-RNO-2076407) Sdc4 [Golgi lumen] (R-RNO-2076330) Sdc4 [Golgi lumen] (R-RNO-2076510) Sdc4 [Golgi lumen] (R-RNO-2076374) Sdc4 [plasma membrane] (R-RNO-2076670) Sdc4 [plasma membrane] (R-RNO-2076633) Sdc4 [plasma membrane] (R-RNO-2076694) Sdc4 [plasma membrane] (R-RNO-2076653) Sdc4 [plasma membrane] (R-RNO-2076674) Sdc4 [plasma membrane] (R-RNO-2076635) Sdc4 [Golgi lumen] (R-RNO-2064100) Sdc4 [Golgi lumen] (R-RNO-2064067) Sdc4 [Golgi lumen] (R-RNO-2064249) Sdc4 [Golgi lumen] (R-RNO-2064195)	0.482	2

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