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PRKCE [cytosol]
Stable Identifier
R-HSA-58202
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein kinase C, epsilon type , nPKC-epsilon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Activation of Protein Kinase C novel isoforms (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Role of phospholipids in phagocytosis (Homo sapiens)
DAG stimulates protein kinase C-delta (Homo sapiens)
PKC-delta/epsilon [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
DAG stimulates protein kinase C-delta (Homo sapiens)
PKC-delta/epsilon [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Activation of Protein Kinase C novel isoforms (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
p(S27)-G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
PKC binds active G alpha (z) (Homo sapiens)
G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
PKC phosphorylates G alpha (z) (Homo sapiens)
G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
p(S27)-G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCE [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02156 PRKCE
Gene Names
PRKCE, PKCE
Chain
chain:1-737
Reference Genes
BioGPS Gene:5581 PRKCE
COSMIC (genes):PRKCE PRKCE
CTD Gene:5581 PRKCE
dbSNP Gene:5581 PRKCE
ENSEMBL:ENSG00000171132 PRKCE
HGNC:9401 PRKCE
KEGG:hsa:5581 PRKCE
Monarch:5581 PRKCE
NCBI Gene:5581 PRKCE
OMIM:176975 PRKCE
UCSC:Q02156 PRKCE
Reference Transcript
RefSeq:XM_005264428.1 PRKCE
RefSeq:NM_005400.2 PRKCE
Other Identifiers
11736257_at
11736258_a_at
206248_PM_at
206248_at
226101_PM_at
226101_at
236459_PM_at
236459_at
2480169
2480170
2480171
2480172
2480184
2480185
2480186
2480192
2480193
2480199
2480200
2480201
2480202
2480203
2480219
2480223
2480224
2480225
2480228
2480231
2480253
2480254
2480255
2480256
2480257
2480258
2480261
2480263
2480264
2480265
2480269
2480270
2480295
2480300
2480316
2480319
2480320
2480321
2480322
2480323
2480332
2480333
2480334
2480335
2480336
2480337
2480338
2480339
32891_at
417_at
49044_at
5581
59772_at
8041763
A_14_P202202
A_23_P250564
A_23_P348194
A_33_P3252191
GO:0000165
GO:0002281
GO:0002376
GO:0003785
GO:0003824
GO:0004672
GO:0004674
GO:0004697
GO:0004699
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005783
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0006468
GO:0006915
GO:0007155
GO:0007165
GO:0008047
GO:0008092
GO:0009407
GO:0010634
GO:0010763
GO:0010811
GO:0012501
GO:0016020
GO:0016740
GO:0018105
GO:0019216
GO:0019899
GO:0023052
GO:0030073
GO:0030546
GO:0030838
GO:0031397
GO:0031589
GO:0031663
GO:0032024
GO:0032230
GO:0032467
GO:0032930
GO:0035276
GO:0035556
GO:0035641
GO:0035669
GO:0038096
GO:0043123
GO:0043226
GO:0043231
GO:0043278
GO:0043410
GO:0045111
GO:0045202
GO:0046872
GO:0048471
GO:0050730
GO:0050996
GO:0051279
GO:0051301
GO:0051649
GO:0051932
GO:0061178
GO:0070254
GO:0070257
GO:0071361
GO:0071380
GO:0071456
GO:0071889
GO:0071944
GO:0080090
GO:0090303
GO:0098754
GO:0098772
GO:0106310
GO:0140096
GO:1902306
GO:1903078
GO:2001031
HMNXSV003011483
HMNXSV003016379
Hs.179991.0.A1_3p_at
Hs.179991.0.A1_3p_x_at
Hs.24379.0.A1_3p_at
ILMN_1717799
PH_hs_0022703
X65293_at
g4885562_3p_at
Participates
as a member of
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PKC-delta/epsilon [cytosol] (Homo sapiens)
Other forms of this molecule
p-T566,T710,S729-PRKCE [plasma membrane]
Inferred To
Homologues of PRKCE [cytosol]
(Dictyostelium discoideum)
Homologues of PRKCE [cytosol]
(Schizosaccharomyces pombe)
PRKCE [cytosol]
(Caenorhabditis elegans)
PRKCE [cytosol]
(Canis familiaris)
PRKCE [cytosol]
(Danio rerio)
PRKCE [cytosol]
(Dictyostelium discoideum)
PRKCE [cytosol]
(Drosophila melanogaster)
PRKCE [cytosol]
(Gallus gallus)
PRKCE [cytosol]
(Mus musculus)
PRKCE [cytosol]
(Rattus norvegicus)
PRKCE [cytosol]
(Saccharomyces cerevisiae)
PRKCE [cytosol]
(Schizosaccharomyces pombe)
PRKCE [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_005391.1
,
XP_005264485.1
ZINC - World Drugs
KPCE_HUMAN
Guide to Pharmacology - Targets
1486
ENSEMBL
ENSP00000306124
,
ENST00000306156
OpenTargets
ENSG00000171132
ZINC - FDA approved
KPCE_HUMAN
ZINC - Substances
KPCE_HUMAN
ZINC - Biogenic
KPCE_HUMAN
ZINC target
Q02156
PRO
Q02156
PDB
5LIH
,
2WH0
ZINC - Investigational
KPCE_HUMAN
IntEnz
2.7.11.13
HPA
ENSG00000171132-PRKCE
Pharos - Targets
Q02156
ZINC - Predictions - Purchasable
KPCE_HUMAN
HMDB Protein
HMDBP01852
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.729
7
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.641
4
UniProt:P15056 BRAF
20
p-S,T-BRAF [cytosol]
(R-HSA-169856)
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
0.589
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.564
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.564
4
UniProt:P17252 PRKCA
8
PRKCA [cytosol]
(R-HSA-58196)
PRKCA [plasma membrane]
(R-HSA-156469)
pT497,T638,S657-PRKCA [plasma membrane]
(R-HSA-4332340)
p-T497,T638,S657-PRKCA [nucleoplasm]
(R-HSA-5223292)
p-T497-PRKCA [cytosol]
(R-HSA-5218731)
p-T497,T638,S657-PRKCA [cytosol]
(R-HSA-4332337)
PRKCA [photoreceptor disc membrane]
(R-HSA-2648987)
PRKCA [nucleoplasm]
(R-HSA-450530)
0.564
2
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
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