Reactome | PRKCI [cytosol]

PRKCI [cytosol]

Stable Identifier

R-HSA-58206

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein kinase C, iota type , nPKC-iota, Atypical protein kinase C-lamda/iota, aPKC-lambda/iota

Icon

Locations in the PathwayBrowser for interactor UniProt:Q8ND90 PNMA1

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Signal Transduction (Homo sapiens)

- Death Receptor Signaling (Homo sapiens)
  - p75 NTR receptor-mediated signalling (Homo sapiens)
    - p75NTR signals via NF-kB (Homo sapiens)
      - p75NTR recruits signalling complexes (Homo sapiens)
        
        p62 recruits an atypical PKC (Homo sapiens)
        
        PRKCI [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P41743 PRKCI

Gene Names

PRKCI, DXS1179E

Chain

initiator methionine:, chain:2-596

Reference Genes

BioGPS Gene:5584 PRKCI

COSMIC (genes):PRKCI PRKCI

CTD Gene:5584 PRKCI

dbSNP Gene:5584 PRKCI

ENSEMBL:ENSG00000163558 PRKCI

ENSEMBL_homo_sapiens_GENE:ENSG00000163558.13 PRKCI

HGNC:9404 PRKCI

KEGG Gene (Homo sapiens):5584 PRKCI

Monarch:5584 PRKCI

NCBI Gene:5584 PRKCI

OMIM:600539 PRKCI

UCSC:P41743 PRKCI

Reference Transcript

RefSeq:NM_002740.5 PRKCI

Other Identifiers

11726772_a_at

11726773_a_at

1602_at

1603_g_at

16947875

209677_PM_at

209677_at

209678_PM_s_at

209678_s_at

213518_PM_at

213518_at

2651915

2651917

2651918

2651919

2651920

2651921

2651922

2651923

2651926

2651927

2651929

2651930

2651931

2651934

2651939

2651940

2651942

2651943

2651954

2651957

2651958

2651959

2651961

2651963

2651967

2651968

2651969

4015817

4015819

4015821

4015822

4015823

4015825

4015826

4015829

4015832

41579_s_at

46745_f_at

5584

57381_r_at

8083854

A_23_P18392

A_33_P3294578

GE57727

GO:0000139

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0005515

GO:0005524

GO:0005543

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0005903

GO:0005923

GO:0006351

GO:0006355

GO:0006468

GO:0006612

GO:0006886

GO:0007010

GO:0007015

GO:0007163

GO:0008289

GO:0010976

GO:0012501

GO:0015630

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016324

GO:0016477

GO:0016740

GO:0023052

GO:0030154

GO:0031252

GO:0031410

GO:0032869

GO:0034330

GO:0034351

GO:0035089

GO:0035556

GO:0036211

GO:0042462

GO:0043066

GO:0043220

GO:0043226

GO:0043434

GO:0043524

GO:0045171

GO:0045177

GO:0045197

GO:0045216

GO:0045747

GO:0046326

GO:0046872

GO:0046903

GO:0048194

GO:0048856

GO:0048870

GO:0051092

GO:0055085

GO:0060252

GO:0061024

GO:0062197

GO:0070062

GO:0070160

GO:0070555

GO:0072659

GO:0080090

GO:0098685

GO:0098978

GO:0099072

GO:0106310

GO:0120157

GO:0140096

GO:1903078

GO:2000353

HMNXSV003006151

Hs.1904.0.S2_3p_at

Hs.47144.1.A1_3p_at

ILMN_1725188

L33881_at

PH_hs_0034114

TC03000914.hg

g432273_3p_a_at

Participates

as a component of

as an input of

p62 recruits an atypical PKC (Homo sapiens)

Other forms of this molecule

PRKCI [nucleoplasm]

PRKCI [plasma membrane]

Inferred To

PRKCI [cytosol] (Bos taurus)

PRKCI [cytosol] (Caenorhabditis elegans)

PRKCI [cytosol] (Canis familiaris)

PRKCI [cytosol] (Danio rerio)

PRKCI [cytosol] (Drosophila melanogaster)

PRKCI [cytosol] (Gallus gallus)

PRKCI [cytosol] (Mus musculus)

PRKCI [cytosol] (Rattus norvegicus)

PRKCI [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_002731.4

ZINC - World Drugs

KPCI_HUMAN

Guide to Pharmacology - Targets

1490

OpenTargets

ENSG00000163558

ZINC - Substances

KPCI_HUMAN

ZINC target

P41743

ZINC - Biogenic

KPCI_HUMAN

PRO

P41743

PDB

6ILZ, 1ZRZ, 3ZH8, 3A8X, 1WMH, 5LI1, 5LI9, 1VD2, 5LIH, 3A8W

ZINC - Investigational

KPCI_HUMAN

GeneCards

P41743

HPA

ENSG00000163558-PRKCI

Ensembl

ENST00000295797, ENSG00000163558, ENSP00000295797

Pharos - Targets

P41743

ZINC - Predictions - Purchasable

KPCI_HUMAN

HMDB Protein

HMDBP01436

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BYG5 PARD6B	2	PARD6B [plasma membrane] (R-HSA-418193) PARD6B [cytosol] (R-HSA-419973)	0.957	25
UniProt:Q9NPB6 PARD6A	4	PARD6A [plasma membrane] (R-HSA-418187) PARD6A [cytosol] (R-HSA-420001) PARD6A [cell junction] (R-HSA-2134480) p-S345-PARD6A [plasma membrane] (R-HSA-2134533)	0.949	17
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.894	11
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.886	10
UniProt:Q6P1M3 L2GL2			0.848	9
UniProt:Q15334 L2GL1			0.788	6
UniProt:Q9BYG4 PARD6G	2	PARD6G [plasma membrane] (R-HSA-418192) PARD6G [cytosol] (R-HSA-419967)	0.716	7
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.708	4
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.67	5
UniProt:Q8TEW0 PARD3	3	PARD3 [plasma membrane] (R-HSA-419980) PARD3 [cytosol] (R-HSA-419993) PARD3 [cell junction] (R-HSA-2134481)	0.623	5
UniProt:P08151-1 GLI1			0.618	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q96RE7 NACC1			0.556	3
UniProt:Q9NPB6-2 PARD6A			0.556	3
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.548	3
UniProt:Q8N5V2 NGEF	2	NGEF [cytosol] (R-HSA-3006800) p-Y179-NGEF [cytosol] (R-HSA-3928441)	0.527	2
UniProt:Q8WVZ9 KBTBD7	1	KBTBD7 [cytosol] (R-HSA-5658415)	0.527	4
UniProt:Q9BPW8 NIPS1			0.527	3
UniProt:O60938 KERA	11	KERA [lysosomal lumen] (R-HSA-2105019) KS(2)-KERA [lysosomal lumen] (R-HSA-2046151) KS(2)-KERA [extracellular region] (R-HSA-2046192) KS(2)-KERA [Golgi lumen] (R-HSA-2046215) KS(1)-KERA [Golgi lumen] (R-HSA-2046290) Keratan(4)-KERA [Golgi lumen] (R-HSA-2046212) Keratan(3)-KERA [Golgi lumen] (R-HSA-2046272) Keratan(2)-KERA [Golgi lumen] (R-HSA-2046267) Keratan(1)-KERA [Golgi lumen] (R-HSA-2046261) Gal-glycan KERA [Golgi lumen] (R-HSA-2046230) N-glycan KERA [Golgi lumen] (R-HSA-2046150)	0.527	2
UniProt:P16070 CD44	2	CD44 [secretory granule membrane] (R-HSA-6804776) CD44 [plasma membrane] (R-HSA-1031688)	0.527	3
UniProt:P02675 FGB	5	FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921) FGB(31-491) [extracellular region] (R-HSA-140846) FGB [plasma membrane] (R-HSA-140917) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [extracellular region] (R-HSA-140584)	0.527	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	3
UniProt:Q8NFN8 GP156			0.527	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2
UniProt:O75323 GBAS	1	NIPSNAP2 [cytosol] (R-HSA-9714668)	0.527	3
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.508	2
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.499	2
UniProt:Q8ND90 PNMA1			0.499	2

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