Reactome | PRKCQ [cytosol]

PRKCQ [cytosol]

Stable Identifier

R-HSA-58216

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein kinase C, theta type , nPKC-theta

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Locations in the PathwayBrowser for interactor UniProt:Q06187 BTK

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
        
        PRKCQ gene expression is stimulated by RUNX1:CBFB (Homo sapiens)
        
        PRKCQ [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q04759 PRKCQ

Gene Names

PRKCQ, PRKCT

Chain

chain:1-706

Reference Genes

BioGPS Gene:5588 PRKCQ

COSMIC (genes):PRKCQ PRKCQ

CTD Gene:5588 PRKCQ

dbSNP Gene:5588 PRKCQ

ENSEMBL:ENSG00000065675 PRKCQ

ENSEMBL_homo_sapiens_GENE:ENSG00000065675.16 PRKCQ

HGNC:9410 PRKCQ

KEGG Gene (Homo sapiens):5588 PRKCQ

Monarch:5588 PRKCQ

NCBI Gene:5588 PRKCQ

OMIM:600448 PRKCQ

UCSC:Q04759 PRKCQ

Reference Transcript

Other Identifiers

11728077_s_at

11747467_a_at

11750753_a_at

16711533

2081_s_at

210038_PM_at

210038_at

210039_PM_s_at

210039_s_at

3275955

3275956

3275957

3275958

3275959

3275960

3275963

3275967

3275969

3275971

3275972

3275977

3275978

3275979

3275981

3275987

3275989

3275990

3275991

3275995

3275997

3276002

3276010

3276011

38949_at

5588

7931930

A_23_P1374

GE79759

GE88182

GO:0000166

GO:0001558

GO:0001772

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0005515

GO:0005524

GO:0005737

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006509

GO:0006954

GO:0007155

GO:0007411

GO:0012501

GO:0016020

GO:0016235

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0032200

GO:0032212

GO:0032740

GO:0032743

GO:0032753

GO:0034451

GO:0035556

GO:0035739

GO:0036211

GO:0038095

GO:0042060

GO:0042110

GO:0043226

GO:0046627

GO:0046872

GO:0048856

GO:0048870

GO:0050870

GO:0050896

GO:0051092

GO:0051973

GO:0060326

GO:0070233

GO:0080090

GO:0090330

GO:0106310

GO:0140096

GO:1904355

GO:2000318

GO:2000563

GO:2000570

HMNXSV003003840

HMNXSV003036575

Hs.211593.0.S2_3p_at

ILMN_1733421

L01087_at

PH_hs_0024719

PH_hs_0033184

TC10001014.hg

g558098_3p_a_at

Participates

as an output of

PRKCQ gene expression is stimulated by RUNX1:CBFB (Homo sapiens)

as a member of

Protein kinase C, novel isoforms [cytosol] (Homo sapiens)

as an input of

Caspase-mediated cleavage of PKC theta (Homo sapiens)

Other forms of this molecule

PRKCQ [photoreceptor disc membrane]

p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane]

PRKCQ(1-354) [cytosol]

PRKCQ(355-706) [cytosol]

PRKQC closed conformation [cytosol]

PRKCQ [plasma membrane]

p-Y90-PRKCQ [plasma membrane]

p-Y90,T538,S676,S695-PRKCQ [plasma membrane]

Inferred To

PRKCQ [cytosol] (Bos taurus)

PRKCQ [cytosol] (Caenorhabditis elegans)

PRKCQ [cytosol] (Canis familiaris)

PRKCQ [cytosol] (Dictyostelium discoideum)

PRKCQ [cytosol] (Drosophila melanogaster)

PRKCQ [cytosol] (Mus musculus)

PRKCQ [cytosol] (Rattus norvegicus)

PRKCQ [cytosol] (Saccharomyces cerevisiae)

PRKCQ [cytosol] (Schizosaccharomyces pombe)

PRKCQ [cytosol] (Sus scrofa)

Homologues of PRKCQ [cytosol] (Dictyostelium discoideum)

Homologues of PRKCQ [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_006717528.1, NP_006248.1, NP_001229342.1, XP_016871899.1, NP_001269574.1, XP_016871900.1, NP_001310194.1, NP_001310195.1, NP_001269573.1

ZINC - World Drugs

KPCT_HUMAN

Guide to Pharmacology - Targets

1488

OpenTargets

ENSG00000065675

ZINC - FDA approved

KPCT_HUMAN

ZINC - Substances

KPCT_HUMAN

ZINC - Biogenic

KPCT_HUMAN

ZINC target

Q04759

PRO

Q04759

PDB

4RA5, 4Q9Z, 1XJD, 2JED, 2ENJ, 2ENN, 2ENZ, 5F9E

ZINC - Investigational

KPCT_HUMAN

ZINC - Metabolites

KPCT_HUMAN

IntEnz

2.7.11.13

HPA

ENSG00000065675-PRKCQ

GeneCards

Q04759

Ensembl

ENST00000539722, ENSP00000441752, ENST00000263125, ENST00000397176, ENSG00000065675, ENSP00000263125, ENSP00000380361

Pharos - Targets

Q04759

ZINC - Predictions - Purchasable

KPCT_HUMAN

HMDB Protein

HMDBP01849

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.66	7
UniProt:Q8IVH8 M4K3			0.639	4
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.602	5
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.581	3
UniProt:Q00613 HSF1	11	p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) HSF1 [cytosol] (R-HSA-3371452)	0.544	2
UniProt:P17028 ZNF24			0.527	2
UniProt:O14523 C2C2L			0.527	2
UniProt:Q9H4E7 DEF6	1	DEF6 [cytosol] (R-HSA-9691487)	0.527	2
UniProt:Q05655 PRKCD	12	PRKCD(1-676) [nucleoplasm] (R-HSA-450606) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) p-T507-PRKCD [cytosol] (R-HSA-5218746) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) PRKCD(330-676) [cytosol] (R-HSA-212551) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD [cytosol] (R-HSA-58200)	0.527	2
UniProt:Q06187 BTK	6	p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) Active BTK [cytosol] (R-HSA-8964323) p-Y551-BTK [cytosol] (R-HSA-2685603) BTK [cytosol] (R-HSA-197948) p-Y551-BTK [plasma membrane] (R-HSA-9606165) p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807)	0.524	2
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.499	2

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