Reactome | SYK [cytosol]

SYK [cytosol]

Stable Identifier

R-HSA-58268

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein kinase SYK , Spleen tyrosine kinase

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Locations in the PathwayBrowser for interactor UniProt:Q8TF42 UBS3B

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External Reference Information

External Reference

UniProt:P43405 SYK

Gene Names

SYK

Chain

chain:1-635

Reference Genes

COSMIC (genes):SYK P434052

dbSNP Gene:6850 P434052

ENSEMBL:ENSG00000165025 SYK

Participates

as an input of

as a component of

as a candidate of

FYN-like kinases [cytosol] (Homo sapiens)

Other forms of this molecule

p-Y-SYK [cytosol]

p-Y-SYK [plasma membrane]

SYK [plasma membrane]

p-6Y-SYK [cytosol]

p-Y348-SYK [cytosol]

Inferred To

SYK [cytosol] (Bos taurus)

SYK [cytosol] (Caenorhabditis elegans)

SYK [cytosol] (Canis familiaris)

SYK [cytosol] (Drosophila melanogaster)

SYK [cytosol] (Gallus gallus)

SYK [cytosol] (Mus musculus)

SYK [cytosol] (Rattus norvegicus)

SYK [cytosol] (Sus scrofa)

SYK [cytosol] (Xenopus tropicalis)

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.873	10
UniProt:Q9UHP3 USP25	1	USP25 [cytosol] (R-HSA-5696900)	0.831	8
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.748	8
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)	0.743	7
UniProt:P36888 FLT3	20	FLT3 F691I [plasma membrane] (R-HSA-9702900) FLT3 N676D [plasma membrane] (R-HSA-9702895) FLT3 R834Q [plasma membrane] (R-HSA-9691899) FLT3 Y572C [plasma membrane] (R-HSA-9691902) FLT3 A848P [plasma membrane] (R-HSA-9702909) FLT3 A627P [plasma membrane] (R-HSA-9699448) FLT3 F621L [plasma membrane] (R-HSA-9699426) p-Y768,Y969 FLT3 [plasma membrane] (R-HSA-9698405) Ub-pY FLT3 [endosome membrane] (R-HSA-9706174) Ub-pY FLT3 [plasma membrane] (R-HSA-9706171) FLT3 V592G [plasma membrane] (R-HSA-9691071) FLT3 F590_F605dup [plasma membrane] (R-HSA-9697939) FLT3 F590G Y591D [plasma membrane] (R-HSA-9691062) FLT3 F594L [plasma membrane] (R-HSA-9691058) FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane] (R-HSA-9699433) FLT3 V579A [plasma membrane] (R-HSA-9691051) FLT3 Y599_D600insGLYVDFREYEY [plasma membrane] (R-HSA-9696044) FLT3 Y591_V592insVDFREDREHH [plasma membrane] (R-HSA-9696043) FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane] (R-HSA-9690076) FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane] (R-HSA-9696033)	0.737	22
UniProt:P20273 CD22	3	p-Y762,807,822-CD22 [plasma membrane] (R-HSA-5690726) CD22 [plasma membrane] (R-HSA-197703) NAc-CD22 [plasma membrane] (R-HSA-5690736)	0.623	4
UniProt:P07766 CD3E	2	p-Y188,Y199-CD3E [plasma membrane] (R-HSA-202228) CD3E [plasma membrane] (R-HSA-197906)	0.597	6
UniProt:Q9ULZ3 PYCARD	4	PYCARD [cytosol] (R-HSA-561191) PYCARD [secretory granule lumen] (R-HSA-6800957) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [azurophil granule lumen] (R-HSA-6798768)	0.591	4
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.581	5
UniProt:Q96IP4 TET5A			0.57	3
UniProt:P30273 FCER1G	5	FCER1G [tertiary granule membrane] (R-HSA-6800183) FCER1G [ficolin-1-rich granule membrane] (R-HSA-6801016) p-Y65-FCER1G [plasma membrane] (R-HSA-2454244) FCER1G [plasma membrane] (R-HSA-54715) p-Y65,Y76-FCER1G [plasma membrane] (R-HSA-141096)	0.564	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.556	3
UniProt:Q8TF42 UBS3B			0.544	2
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.508	2
ChEBI:39112 BOSUTINIB			0.499	2
UniProt:P11049 CD37			0.499	3
ChEBI:49375 DASATINIB			0.499	2
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.462	4
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	3

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