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NDUFB4 [mitochondrial inner membrane]
Stable Identifier
R-HSA-59934
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH-ubiquinone oxidoreductase B15 subunit , Complex I-B15, CI-B15
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95168 NDUFB4
Gene Names
NDUFB4
Chain
initiator methionine:1, chain:2-129
Reference Genes
BioGPS Gene:4710 NDUFB4
COSMIC - genes:NDUFB4 NDUFB4
CTD Gene:4710 NDUFB4
dbSNP Gene:4710 NDUFB4
ENSEMBL:ENSG00000065518 NDUFB4
HGNC:7699 NDUFB4
KEGG:hsa:4710 NDUFB4
Monarch:4710 NDUFB4
NCBI Gene:4710 NDUFB4
OMIM:603840 NDUFB4
UCSC:O95168 NDUFB4
Reference Transcript
RefSeq:NM_001168331.2 NDUFB4
RefSeq:NM_004547.5 NDUFB4
Other Identifiers
11718278_s_at
11745384_s_at
11760040_x_at
16944502
218226_PM_s_at
218226_s_at
228940_PM_at
228940_at
2638440
2638441
2638442
2638448
2638449
2638450
2638451
2638452
2638453
4047218
4047219
4047220
4047221
4047222
4047223
4047226
4047227
4047228
4710
65777_at
65778_at
8081945
8093314
A_23_P69468
GE61710
GE79271
GE87765
GO:0005654
GO:0005739
GO:0005743
GO:0006091
GO:0006120
GO:0008137
GO:0009060
GO:0016020
GO:0016491
GO:0042776
GO:0045271
GO:0055085
GO:0055086
GO:1901135
GO:1902600
HMNXSV003051864
Hs.227750.1.S1_3p_a_at
Hs.227750.1.S1_3p_x_at
ILMN_1668027
ILMN_1721719
ILMN_1770589
ILMN_2081863
PH_hs_0012660
PH_hs_0026966
TC03000617.hg
g6041668_3p_a_at
Participates
as a component of
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
Inferred To
ndufb4 [mitochondrial inner membrane]
(Danio rerio)
ndufb4 [mitochondrial inner membrane]
(Xenopus tropicalis)
nuo-6 [mitochondrial inner membrane]
(Caenorhabditis elegans)
NDUFB4 [mitochondrial inner membrane]
(Bos taurus)
NDUFB4 [mitochondrial inner membrane]
(Canis familiaris)
NDUFB4 [mitochondrial inner membrane]
(Gallus gallus)
NDUFB4 [mitochondrial inner membrane]
(Rattus norvegicus)
NDUFB4 [mitochondrial inner membrane]
(Sus scrofa)
Ndufb4 [mitochondrial inner membrane]
(Mus musculus)
ND-B15 [mitochondrial inner membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_004538.2
,
NP_001161803.1
ENSEMBL
ENSG00000065518
,
ENSP00000184266
,
ENST00000184266
,
ENSP00000419578
,
ENST00000485064
OpenTargets
ENSG00000065518
GeneCards
NDUFB4
HPA
ENSG00000065518-NDUFB4
PRO
O95168
Pharos - Targets
O95168
HMDB Protein
HMDBP00149
PDB
5XTD
,
5XTC
,
5XTI
,
5XTH
,
9CWT
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.643
6
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.527
4
UniProt:O43920 NDUFS5
1
NDUFS5 [mitochondrial inner membrane]
(R-HSA-60226)
0.527
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.527
2
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