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NME1 [cytosol]
Stable Identifier
R-HSA-60022
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
non-metastatic cells 1, protein (NM23A) expressed in, Nucleoside diphosphate kinase A, nm23-H1, Nucleoside diphosphate kinase A , NDK A, NDP kinase A, Tumor metastatic process-associated protein, Metastasis inhibition factor nm23
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Homo sapiens)
NME1:NME2 hexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Homo sapiens)
NME1:NME2 hexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
Ribavirin ADME (Homo sapiens)
NME1,2 hexamers phosphorylate RBV-DP (Homo sapiens)
NME1,2 hexamers [cytosol] (Homo sapiens)
NME1:NME2 hexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 1A:5B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 2A:4B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 4A:2B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 5A:1B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase A hexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Homo sapiens)
NME1,2 hexamers [cytosol] (Homo sapiens)
NME1:NME2 hexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 1A:5B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 2A:4B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 4A:2B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 5A:1B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase A hexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Homo sapiens)
NME1,2 hexamers [cytosol] (Homo sapiens)
NME1:NME2 hexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 1A:5B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 2A:4B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 4A:2B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 5A:1B heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase A hexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Homo sapiens)
NME1:NME3 heterohexamer, NME2P1 [cytosol] (Homo sapiens)
NME1:NME3 heterohexamer [cytosol] (Homo sapiens)
NME1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15531 NME1
Gene Names
NME1, NDPKA, NM23
Chain
chain:1-152
Reference Genes
BioGPS Gene:4830 NME1
COSMIC (genes):NME1 NME1
CTD Gene:4830 NME1
dbSNP Gene:4830 NME1
ENSEMBL:ENSG00000239672 NME1
HGNC:7849 NME1
KEGG:hsa:4830 NME1
Monarch:4830 NME1
NCBI Gene:4830 NME1
OMIM:156490 NME1
UCSC:P15531 NME1
Reference Transcript
RefSeq:NM_198175.1 NME1
RefSeq:NM_000269.2 NME1
Other Identifiers
11717155_a_at
1521_at
1985_s_at
201577_PM_at
201577_at
3726941
3726942
3726943
3726944
3726945
3726947
3726948
3726949
3726950
3726951
3726952
3726953
3726954
3726955
3726956
3726957
3726958
3726959
39073_at
4830
71854_at
8008517
A_14_P105902
A_14_P119911
A_23_P152804
GE59748
GO:0000287
GO:0003723
GO:0003824
GO:0004536
GO:0004550
GO:0005515
GO:0005524
GO:0005525
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0006183
GO:0006228
GO:0006241
GO:0006259
GO:0006897
GO:0007399
GO:0007595
GO:0008285
GO:0008408
GO:0009117
GO:0016020
GO:0016192
GO:0016301
GO:0016740
GO:0016787
GO:0030154
GO:0030879
GO:0031410
GO:0032587
GO:0042802
GO:0042981
GO:0043024
GO:0043226
GO:0043388
GO:0046872
GO:0048856
GO:0050679
GO:0055086
GO:0070062
GO:0140097
GO:1901135
HMNXSV003011494
ILMN_1713875
ILMN_1741133
ILMN_2414399
PH_hs_0035541
TC17002276.hg
TC17002880.hg
X17620_at
g4557796_3p_at
Participates
as a component of
NME1:NME3 heterohexamer [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 4A:2B heterohexamer [cytosol] (Homo sapiens)
nucleoside diphosphate kinase A hexamer [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 1A:5B heterohexamer [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 5A:1B heterohexamer [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 2A:4B heterohexamer [cytosol] (Homo sapiens)
NME1:NME2 hexamer [cytosol] (Homo sapiens)
Inferred To
nme2a [cytosol]
(Danio rerio)
NME1 [cytosol]
(Bos taurus)
NME1 [cytosol]
(Canis familiaris)
NME1 [cytosol]
(Dictyostelium discoideum)
NME1 [cytosol]
(Drosophila melanogaster)
NME1 [cytosol]
(Gallus gallus)
NME1 [cytosol]
(Mus musculus)
NME1 [cytosol]
(Plasmodium falciparum)
NME1 [cytosol]
(Rattus norvegicus)
NME1 [cytosol]
(Saccharomyces cerevisiae)
NME1 [cytosol]
(Schizosaccharomyces pombe)
NME1 [cytosol]
(Sus scrofa)
ndk-1 [cytosol]
(Caenorhabditis elegans)
Cross References
ENSEMBL
ENST00000393196
,
ENST00000013034
,
ENSP00000013034
,
ENSG00000239672
,
ENSP00000337060
,
ENSP00000376892
,
ENST00000336097
OpenTargets
ENSG00000239672
GeneCards
NME1
HPA
ENSG00000239672-NME1
ZINC - Substances
NDKA_HUMAN
ZINC target
P15531
PRO
P15531
Pharos - Targets
P15531
GlyGen
P15531
HMDB Protein
HMDBP00109
PDB
2HVE
,
8OOV
,
1UCN
,
1JXV
,
5UI4
,
3L7U
,
4ENO
,
2HVD
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15160 POLR1C
2
POLR1C [cytosol]
(R-HSA-1964454)
POLR1C [nucleoplasm]
(R-HSA-63498)
0.87
11
UniProt:Q9Y3F4 STRAP
1
STRAP [cytosol]
(R-HSA-2127556)
0.668
9
UniProt:P10911 MCF2
1
MCF2 [cytosol]
(R-HSA-3006639)
0.532
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
8
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