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NDUFA2 [mitochondrial inner membrane]
Stable Identifier
R-HSA-60178
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH-ubiquinone oxidoreductase B8 subunit , Complex I-B8, CI-B8
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43678 NDUFA2
Gene Names
NDUFA2
Chain
initiator methionine:1, chain:2-99
Reference Genes
BioGPS Gene:4695 NDUFA2
COSMIC (genes):NDUFA2 NDUFA2
CTD Gene:4695 NDUFA2
dbSNP Gene:4695 NDUFA2
ENSEMBL:ENSG00000131495.9 NDUFA2
HGNC:7685 NDUFA2
KEGG Gene (Homo sapiens):4695 NDUFA2
Monarch:4695 NDUFA2
NCBI Gene:4695 NDUFA2
OMIM:602137 NDUFA2
UCSC:O43678 NDUFA2
Reference Transcript
RefSeq:NM_001185012.1 NDUFA2
RefSeq:NM_002488.4 NDUFA2
Other Identifiers
0006550154
11718831_at
17000800
209224_PM_s_at
209224_s_at
2878449
2878450
2878451
2878455
2878457
40546_s_at
4695
63514_at
7894479
7895842
8114618
A_23_P257795
A_24_P12218
GE54402
GO:0001835
GO:0005215
GO:0005622
GO:0005737
GO:0005739
GO:0005743
GO:0005747
GO:0006091
GO:0006120
GO:0007005
GO:0008137
GO:0009060
GO:0016020
GO:0016491
GO:0031966
GO:0032981
GO:0032991
GO:0042776
GO:0043226
GO:0044271
GO:0048856
GO:0055086
GO:0065003
GO:0070469
GO:1901135
GO:1901566
HMNXSV003053434
ILMN_1767123
ILMN_3243890
PH_hs_0009907
PH_hs_0035627
TC05001862.hg
TC05003269.hg
g13277539_3p_a_at
Participates
as a component of
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
Inferred To
ndufa2 [mitochondrial inner membrane]
(Xenopus tropicalis)
ND-B8 [mitochondrial inner membrane]
(Drosophila melanogaster)
Ndufa2 [mitochondrial inner membrane]
(Mus musculus)
Ndufa2 [mitochondrial inner membrane]
(Rattus norvegicus)
zgc:112340 [mitochondrial inner membrane]
(Danio rerio)
NDUFA2 [mitochondrial inner membrane]
(Bos taurus)
NDUFA2 [mitochondrial inner membrane]
(Caenorhabditis elegans)
NDUFA2 [mitochondrial inner membrane]
(Canis familiaris)
NDUFA2 [mitochondrial inner membrane]
(Gallus gallus)
NDUFA2 [mitochondrial inner membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001171941.1
,
NP_002479.1
OpenTargets
ENSG00000131495
HPA
ENSG00000131495-NDUFA2
GeneCards
O43678
Ensembl
ENSG00000131495
,
ENST00000512088
,
ENSP00000427220
,
ENSP00000252102
,
ENST00000252102
PRO
O43678
Pharos - Targets
O43678
Orphanet
19734
PDB
1S3A
,
5XTI
,
5XTD
,
5XTB
,
5XTH
HMDB Protein
HMDBP00159
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.744
8
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.564
3
UniProt:O43920 NDUFS5
1
NDUFS5 [mitochondrial inner membrane]
(R-HSA-60226)
0.564
3
UniProt:P49821 NDUFV1
1
NDUFV1 [mitochondrial inner membrane]
(R-HSA-163926)
0.564
3
UniProt:Q9UI09 NDUFA12
1
NDUFA12 [mitochondrial inner membrane]
(R-HSA-59864)
0.564
3
UniProt:O43181 NDUFS4
1
NDUFS4 [mitochondrial inner membrane]
(R-HSA-163946)
0.564
3
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