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NDUFA2 [mitochondrial inner membrane]
Stable Identifier
R-HSA-60178
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH-ubiquinone oxidoreductase B8 subunit , Complex I-B8, CI-B8
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
LONP1 binds mitochondrial inner membrane proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial inner membrane) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
LONP1 degrades mitochondrial inner membrane proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial inner membrane) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
NDUFA2 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43678 NDUFA2
Gene Names
NDUFA2
Chain
initiator methionine:, chain:2-99
Reference Genes
BioGPS Gene:4695 NDUFA2
COSMIC (genes):NDUFA2 NDUFA2
CTD Gene:4695 NDUFA2
dbSNP Gene:4695 NDUFA2
ENSEMBL:ENSG00000131495 NDUFA2
HGNC:7685 NDUFA2
KEGG:hsa:4695 NDUFA2
Monarch:4695 NDUFA2
NCBI Gene:4695 NDUFA2
OMIM:602137 NDUFA2
UCSC:O43678 NDUFA2
Reference Transcript
RefSeq:NM_001185012.1 NDUFA2
RefSeq:NM_002488.4 NDUFA2
Other Identifiers
11718831_at
17000800
209223_PM_at
209223_at
209224_PM_s_at
209224_s_at
2878447
2878449
2878450
2878451
2878455
2878456
2878457
2878458
40546_s_at
4695
63514_at
7894479
7895842
8114618
A_23_P257795
A_24_P12218
GE54402
GO:0001835
GO:0003824
GO:0005215
GO:0005739
GO:0005743
GO:0006091
GO:0006120
GO:0008137
GO:0009060
GO:0016491
GO:0031966
GO:0032981
GO:0042776
GO:0043226
GO:0045271
GO:0055085
GO:0055086
GO:0065003
GO:1901135
GO:1902600
HMNXSV003053434
Hs.163867.0.S1_3p_at
PH_hs_0009907
PH_hs_0035627
TC05001862.hg
TC05003269.hg
g13277539_3p_a_at
Participates
as a member of
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
as a component of
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
Inferred To
ndua-2 [mitochondrial inner membrane]
(Caenorhabditis elegans)
ndufa2 [mitochondrial inner membrane]
(Danio rerio)
ndufa2 [mitochondrial inner membrane]
(Xenopus tropicalis)
LOC106507363 [mitochondrial inner membrane]
(Sus scrofa)
ND-B8 [mitochondrial inner membrane]
(Drosophila melanogaster)
Ndufa2 [mitochondrial inner membrane]
(Mus musculus)
Ndufa2 [mitochondrial inner membrane]
(Rattus norvegicus)
NDUFA2 [mitochondrial inner membrane]
(Bos taurus)
NDUFA2 [mitochondrial inner membrane]
(Canis familiaris)
NDUFA2 [mitochondrial inner membrane]
(Dictyostelium discoideum)
NDUFA2 [mitochondrial inner membrane]
(Gallus gallus)
Cross References
ENSEMBL
ENSP00000252102
,
ENSG00000131495
,
ENST00000252102
,
ENSP00000427220
,
ENST00000512088
OpenTargets
ENSG00000131495
GeneCards
NDUFA2
HPA
ENSG00000131495-NDUFA2
PRO
O43678
Pharos - Targets
O43678
Orphanet
NDUFA2
HMDB Protein
HMDBP00159
PDB
1S3A
,
5XTI
,
5XTH
,
5XTB
,
5XTD
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.802
9
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.669
6
UniProt:O43181 NDUFS4
1
NDUFS4 [mitochondrial inner membrane]
(R-HSA-163946)
0.564
3
UniProt:P56181 NDUFV3
1
NDUFV3 [mitochondrial inner membrane]
(R-HSA-163943)
0.564
5
UniProt:O43920 NDUFS5
1
NDUFS5 [mitochondrial inner membrane]
(R-HSA-60226)
0.564
3
UniProt:Q9P0J0 NDUFA13
8
NDUFA13 [mitochondrial inner membrane]
(R-HSA-59936)
NDUFA13(41-49) [mitochondrial inner membrane]
(R-HSA-9839958)
NDUFA13(100-108) [mitochondrial inner membrane]
(R-HSA-9839959)
NDUFA13(109-144) [mitochondrial inner membrane]
(R-HSA-9839968)
NDUFA13(2-19) [mitochondrial inner membrane]
(R-HSA-9839966)
NDUFA13(69-99) [mitochondrial inner membrane]
(R-HSA-9839964)
NDUFA13(20-40) [mitochondrial inner membrane]
(R-HSA-9839963)
NDUFA13(50-68) [mitochondrial inner membrane]
(R-HSA-9839961)
0.564
3
UniProt:Q9UI09 NDUFA12
1
NDUFA12 [mitochondrial inner membrane]
(R-HSA-59864)
0.564
3
UniProt:P49821 NDUFV1
1
NDUFV1 [mitochondrial inner membrane]
(R-HSA-163926)
0.564
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.564
3
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