Reactome | NDUFS5 [mitochondrial inner membrane]

NDUFS5 [mitochondrial inner membrane]

Stable Identifier

R-HSA-60226

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase 15 kDa subunit , Complex I-15 kDa, CI-15 kDa

Locations in the PathwayBrowser for interactor UniProt:O75306 NDUFS2

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External Reference Information

External Reference

UniProt:O43920 NDUFS5

Gene Names

NDUFS5

Chain

chain:1-106

Reference Genes

BioGPS Gene:4725 NDUFS5

COSMIC (genes):NDUFS5 NDUFS5

CTD Gene:4725 NDUFS5

dbSNP Gene:4725 NDUFS5

ENSEMBL:ENSG00000168653 NDUFS5

ENSEMBL_homo_sapiens_GENE:ENSG00000168653.11 NDUFS5

HGNC:7712 NDUFS5

KEGG Gene (Homo sapiens):4725 NDUFS5

Monarch:4725 NDUFS5

NCBI Gene:4725 NDUFS5

OMIM:603847 NDUFS5

Reference Transcript

Other Identifiers

11757665_x_at

16662744

201757_PM_at

201757_at

2331179

2331181

2331185

2331186

3751300

3751301

38060_at

4725

7900228

A_23_P10463

GE54406

GO:0003824

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0005747

GO:0005758

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0009060

GO:0016020

GO:0016491

GO:0032981

GO:0042776

GO:0043226

GO:0055086

GO:0065003

GO:0070469

GO:1901135

HMNXSV003016017

ILMN_1776104

PH_hs_0019510

TC01000492.hg

g4758789_3p_at

Participates

as an input of

Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)

as a component of

Inferred To

NDUFS5 [mitochondrial inner membrane] (Bos taurus)

NDUFS5 [mitochondrial inner membrane] (Canis familiaris)

NDUFS5 [mitochondrial inner membrane] (Gallus gallus)

NDUFS5 [mitochondrial inner membrane] (Sus scrofa)

Ndufs5 [mitochondrial inner membrane] (Mus musculus)

Ndufs5 [mitochondrial inner membrane] (Rattus norvegicus)

Ghost homologue of NDUFS5 [mitochondrial inner membrane] (Caenorhabditis elegans)

Ghost homologue of NDUFS5 [mitochondrial inner membrane] (Drosophila melanogaster)

Ghost homologue of NDUFS5 [mitochondrial inner membrane] (Xenopus tropicalis)

ndufs5 [mitochondrial inner membrane] (Danio rerio)

Cross References

RefSeq

NP_001171908.1, NP_004543.1

OpenTargets

ENSG00000168653

HPA

ENSG00000168653-NDUFS5

GeneCards

O43920

Ensembl

ENSP00000362058, ENST00000372967, ENST00000372969, ENSG00000168653, ENSP00000362060

PRO

O43920

Pharos - Targets

O43920

Orphanet

24752

HMDB Protein

HMDBP00141

PDB

5XTI, 5XTD, 5XTH, 5XTC

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95831 AIFM1			0.671	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:P56556 NDUFA6	1	NDUFA6 [mitochondrial inner membrane] (R-HSA-59932)	0.643	3
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.643	5
UniProt:Q9P032 NDUFAF4	1	NDUFAF4 [mitochondrial inner membrane] (R-HSA-5689124)	0.643	3
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.643	6
UniProt:Q9Y375 NDUFAF1	1	NDUFAF1 [mitochondrial inner membrane] (R-HSA-5689050)	0.643	4
UniProt:O43678 NDUFA2	1	NDUFA2 [mitochondrial inner membrane] (R-HSA-60178)	0.564	3
UniProt:Q9NP61 ARFGAP3	1	ARFGAP3 [cytosol] (R-HSA-6807740)	0.556	3
UniProt:Q2NKQ1-4 SGSM1			0.556	3
UniProt:Q496A3 SPAS1			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:O95182 NDUFA7	1	NDUFA7 [mitochondrial inner membrane] (R-HSA-59858)	0.527	3
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	2
UniProt:Q9Y6M9 NDUFB9	1	NDUFB9 [mitochondrial inner membrane] (R-HSA-60176)	0.527	3
UniProt:P28331 NDUFS1	1	NDUFS1 [mitochondrial matrix] (R-HSA-6788513)	0.527	2
UniProt:O95168 NDUFB4	1	NDUFB4 [mitochondrial inner membrane] (R-HSA-59934)	0.527	3
UniProt:O00217 NDUFS8	1	NDUFS8 [mitochondrial matrix] (R-HSA-6788526)	0.527	2
UniProt:O95169 NDUFB8	4	NDUFB8 [mitochondrial inner membrane] (R-HSA-163938) NDUFB8(1-28) [mitochondrial matrix] (R-HSA-8986166) NDUFB8(1-186) [mitochondrial inner membrane] (R-HSA-8986184) NDUFB8(1-186) [mitochondrial intermembrane space] (R-HSA-8986140)	0.527	3
UniProt:P03886 MT-ND1	1	MT-ND1 [mitochondrial inner membrane] (R-HSA-60551)	0.527	2
UniProt:O43674 NDUFB5	1	NDUFB5 [mitochondrial inner membrane] (R-HSA-163944)	0.527	3
UniProt:Q9NX14 NDUFB11	1	NDUFB11 [mitochondrial inner membrane] (R-HSA-163933)	0.527	3
UniProt:P17568 NDUFB7	1	NDUFB7 [mitochondrial inner membrane] (R-HSA-59940)	0.527	2
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	3
UniProt:O96000 NDUFB10	1	NDUFB10 [mitochondrial inner membrane] (R-HSA-60194)	0.527	2
UniProt:Q9H845 ACAD9	1	ACAD9 [mitochondrial inner membrane] (R-HSA-5689049)	0.527	2
UniProt:O75306 NDUFS2	1	NDUFS2 [mitochondrial matrix] (R-HSA-6788520)	0.527	2
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.527	3
UniProt:Q16795 NDUFA9	1	NDUFA9 [mitochondrial matrix] (R-HSA-163942)	0.527	2
UniProt:P56181 NDUFV3	1	NDUFV3 [mitochondrial inner membrane] (R-HSA-163943)	0.527	4
UniProt:O95139 NDUFB6	1	NDUFB6 [mitochondrial inner membrane] (R-HSA-59938)	0.527	3
UniProt:P03915 MT-ND5	1	MT-ND5 [mitochondrial inner membrane] (R-HSA-60565)	0.527	3
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.527	3
UniProt:O43181 NDUFS4	1	NDUFS4 [mitochondrial inner membrane] (R-HSA-163946)	0.527	3
UniProt:P03905 MT-ND4	1	MT-ND4 [mitochondrial inner membrane] (R-HSA-60561)	0.527	3
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.527	2
UniProt:Q9UI09 NDUFA12	1	NDUFA12 [mitochondrial inner membrane] (R-HSA-59864)	0.527	3
UniProt:Q9P0J0 NDUFA13	8	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936) NDUFA13(41-49) [mitochondrial inner membrane] (R-HSA-9839958) NDUFA13(100-108) [mitochondrial inner membrane] (R-HSA-9839959) NDUFA13(109-144) [mitochondrial inner membrane] (R-HSA-9839968) NDUFA13(2-19) [mitochondrial inner membrane] (R-HSA-9839966) NDUFA13(69-99) [mitochondrial inner membrane] (R-HSA-9839964) NDUFA13(20-40) [mitochondrial inner membrane] (R-HSA-9839963) NDUFA13(50-68) [mitochondrial inner membrane] (R-HSA-9839961)	0.527	2

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