Reactome | MT-ND4 [mitochondrial inner membrane]

MT-ND4 [mitochondrial inner membrane]

Stable Identifier

R-HSA-60561

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3)

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Locations in the PathwayBrowser for interactor UniProt:Q9P0J0 NDUFA13

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External Reference Information

External Reference

UniProt:P03905 MT-ND4

Gene Names

MT-ND4, MTND4, NADH4, ND4

Chain

chain:1-459

Reference Genes

BioGPS Gene:4538 MT-ND4

COSMIC (genes):MT-ND4 MT-ND4

CTD Gene:4538 MT-ND4

dbSNP Gene:4538 MT-ND4

ENSEMBL:ENSG00000198886 MT-ND4

ENSEMBL_homo_sapiens_GENE:ENSG00000198886.2 MT-ND4

HGNC:7459 MT-ND4

KEGG Gene (Homo sapiens):4538 MT-ND4

Monarch:4538 MT-ND4

NCBI Gene:4538 MT-ND4

OMIM:516003 MT-ND4

UCSC:P03905 MT-ND4

Reference Transcript

RefSeq:NC_012920.1 MT-ND4

Other Identifiers

11764256_s_at

17100673

17100675

17100677

17100679

17100681

17119762

17126270

17126272

17126278

211600_PM_at

211600_at

224372_PM_at

224372_at

224373_PM_s_at

224373_s_at

4037657

4037658

4037659

4037660

4037661

4037662

4037664

4037666

4037668

4037670

4037671

4538

8165676

8165680

8165682

8165684

A_23_P315252

GO:0001666

GO:0001701

GO:0003824

GO:0003954

GO:0005215

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0009060

GO:0015990

GO:0016020

GO:0016491

GO:0021549

GO:0031966

GO:0032981

GO:0035094

GO:0042773

GO:0042776

GO:0043226

GO:0045471

GO:0048039

GO:0048856

GO:0055085

GO:0055086

GO:0065003

GO:0070469

GO:1901135

HMNXSV003015713

RNA143452|tRNA_369_71

RNA143502|tRNA_419_69

TC08001295.hg

TC0M000007.hg

TC0M000008.hg

TC0M000009.hg

TC0M000023.hg

TC0M000024.hg

g12005804_3p_at

g885925_3p_at

p28385

Participates

as an output of

MT-ND4 is translated (Homo sapiens)

as an input of

ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)

as a component of

Inferred To

nduo-4 [mitochondrial inner membrane] (Caenorhabditis elegans)

mt-nd4 [mitochondrial inner membrane] (Danio rerio)

mt-nd4 [mitochondrial inner membrane] (Xenopus tropicalis)

Ghost homologue of MT-ND4 [mitochondrial inner membrane] (Canis familiaris)

Mt-nd4 [mitochondrial inner membrane] (Rattus norvegicus)

Mtnd4 [mitochondrial inner membrane] (Mus musculus)

mt:ND4 [mitochondrial inner membrane] (Drosophila melanogaster)

MT-ND4 [mitochondrial inner membrane] (Bos taurus)

MT-ND4 [mitochondrial inner membrane] (Gallus gallus)

MT-ND4 [mitochondrial inner membrane] (Sus scrofa)

Cross References

RefSeq

YP_003024035.1

OpenTargets

ENSG00000198886

ZINC - Substances

NU4M_HUMAN

ZINC - Biogenic

NU4M_HUMAN

ZINC target

P03905

PRO

P03905

PDB

5XTD, 5XTI, 5XTC, 5XTH

ZINC - Metabolites

NU4M_HUMAN

IntEnz

7.1.1.2

GeneCards

P03905

HPA

ENSG00000198886-MT-ND4

Ensembl

ENSP00000354961, ENSG00000198886, ENST00000361381

Pharos - Targets

P03905

Orphanet

16481

ZINC - Predictions - Purchasable

NU4M_HUMAN

HMDB Protein

HMDBP00178

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.643	3
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.643	5
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	2
UniProt:Q9GZM5 YIPF3			0.527	4
UniProt:O43674 NDUFB5	1	NDUFB5 [mitochondrial inner membrane] (R-HSA-163944)	0.527	3
UniProt:P51970 NDUFA8	1	NDUFA8 [mitochondrial inner membrane] (R-HSA-60627)	0.527	2
UniProt:P41587 VIPR2	1	VIPR2 [plasma membrane] (R-HSA-420227)	0.527	3
UniProt:O43920 NDUFS5	1	NDUFS5 [mitochondrial inner membrane] (R-HSA-60226)	0.527	3
UniProt:Q9P0J0 NDUFA13	8	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936) NDUFA13(41-49) [mitochondrial inner membrane] (R-HSA-9839958) NDUFA13(100-108) [mitochondrial inner membrane] (R-HSA-9839959) NDUFA13(109-144) [mitochondrial inner membrane] (R-HSA-9839968) NDUFA13(2-19) [mitochondrial inner membrane] (R-HSA-9839966) NDUFA13(69-99) [mitochondrial inner membrane] (R-HSA-9839964) NDUFA13(20-40) [mitochondrial inner membrane] (R-HSA-9839963) NDUFA13(50-68) [mitochondrial inner membrane] (R-HSA-9839961)	0.527	3
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.527	2

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