Reactome | NDUFA4 [mitochondrial inner membrane]

NDUFA4 [mitochondrial inner membrane]

Stable Identifier

R-HSA-60617

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase MLRQ subunit , Complex I-MLRQ, CI-MLRQ

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA4:CL [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA4 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA4:CL [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA4 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00483 NDUFA4

Gene Names

NDUFA4

Chain

chain:1-81

Reference Genes

BioGPS Gene:4697 NDUFA4

COSMIC (genes):NDUFA4 NDUFA4

CTD Gene:4697 NDUFA4

dbSNP Gene:4697 NDUFA4

ENSEMBL:ENSG00000189043 NDUFA4

HGNC:7687 NDUFA4

KEGG:hsa:4697 NDUFA4

Monarch:4697 NDUFA4

NCBI Gene:4697 NDUFA4

OMIM:603833 NDUFA4

UCSC:O00483 NDUFA4

Reference Transcript

RefSeq:NM_002489.3 NDUFA4

Other Identifiers

11715369_s_at

11758716_at

11758717_x_at

17055247

217773_PM_s_at

217773_s_at

2350003

3038616

3038618

3038619

3038620

3038621

3038622

3038623

3038624

3038625

3038626

3038627

3038628

3038629

4697

48832_at

51793_s_at

75068_at

8138224

A_23_P145777

GE78946

GE85927

GO:0003824

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0006091

GO:0006120

GO:0006123

GO:0008137

GO:0016491

GO:0031966

GO:0043226

GO:0044877

GO:0045277

GO:0045333

GO:0055085

GO:1902600

HMNXSV003014752

ILMN_1751258

PH_hs_0003468

TC07001145.hg

U94586_at

g4505356_3p_a_at

Participates

as a component of

NDUFA4:CL [mitochondrial inner membrane] (Homo sapiens)

Inferred To

LOC100688724 [mitochondrial inner membrane] (Canis familiaris)

NDUFA4 [mitochondrial inner membrane] (Bos taurus)

NDUFA4 [mitochondrial inner membrane] (Canis familiaris)

NDUFA4 [mitochondrial inner membrane] (Gallus gallus)

NDUFA4 [mitochondrial inner membrane] (Rattus norvegicus)

NDUFA4 [mitochondrial inner membrane] (Sus scrofa)

LOC100682956 [mitochondrial inner membrane] (Canis familiaris)

Ndufa4 [mitochondrial inner membrane] (Mus musculus)

ndufa4a [mitochondrial inner membrane] (Danio rerio)

ndufa4 [mitochondrial inner membrane] (Danio rerio)

Homologues of NDUFA4 [mitochondrial inner membrane] (Bos taurus)

Homologues of NDUFA4 [mitochondrial inner membrane] (Canis familiaris)

Homologues of NDUFA4 [mitochondrial inner membrane] (Danio rerio)

ND-MLRQ [mitochondrial inner membrane] (Drosophila melanogaster)

Ghost homologue of NDUFA4 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000339600, ENSP00000339720

OpenTargets

ENSG00000189043

HPA

ENSG00000189043-NDUFA4

ZINC - Substances

NDUA4_HUMAN

ZINC target

O00483

PRO

O00483

Pharos - Targets

O00483

GlyGen

O00483

Orphanet

NDUFA4

ZINC - Predictions - Purchasable

NDUA4_HUMAN

HMDB Protein

HMDBP00131

PDB

5Z62

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UI09 NDUFA12	1	NDUFA12 [mitochondrial inner membrane] (R-HSA-59864)	0.527	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.527	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.527	2

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