Reactome | NPM1 [nucleoplasm]

NPM1 [nucleoplasm]

Stable Identifier

R-HSA-606320

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nucleophosmin, B23, NPM_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P46013 KI67

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
        
        NPM1-ALK binds NPM1 and FOXM1 (Homo sapiens)
        
        NPM1 [nucleoplasm] (Homo sapiens)
- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - Host Interactions of HIV factors (Homo sapiens)
        
        Interactions of Rev with host cellular proteins (Homo sapiens)
        
        Nuclear import of Rev protein (Homo sapiens)
        
        Disassembly of the Rev-importin beta-B23:Ran-GTP complex (Homo sapiens)
        
        NPM1 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
      - TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation (Homo sapiens)
        
        NPM1 binds TFAP2A homodimer (Homo sapiens)
        
        NPM1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06748 NPM1

Gene Names

NPM1, NPM

Chain

chain:1-294

Reference Genes

BioGPS Gene:4869 NPM1

COSMIC (genes):NPM1 NPM1

CTD Gene:4869 NPM1

dbSNP Gene:4869 NPM1

ENSEMBL:ENSG00000181163 NPM1

ENSEMBL_homo_sapiens_GENE:ENSG00000181163.14 NPM1

HGNC:7910 NPM1

KEGG Gene (Homo sapiens):4869 NPM1

Monarch:4869 NPM1

NCBI Gene:4869 NPM1

OMIM:164040 NPM1

UCSC:P06748 NPM1

Reference Transcript

Other Identifiers

11730790_x_at

11730912_at

11754066_x_at

11757362_x_at

11757386_x_at

16656591

16656593

16656595

18670158

18670159

18670165

18670166

18670167

200063_PM_s_at

200063_s_at

221691_3p_x_at

221691_PM_x_at

221691_x_at

221923_PM_s_at

221923_s_at

2326906

2666248

2840617

2840618

2840620

2840621

2840623

2840626

2840627

2840628

2840629

2840631

2840633

2840638

2840640

2840641

2840642

2840643

2840646

2840647

2840648

2867271

2867272

2867273

2867274

2867275

2867281

2867283

2960052

2960054

3100478

3100479

3136166

3404467

3404471

38542_at

4869

78344_at

7892530

7892853

7893382

7893420

7893571

7893657

7894485

7894919

7895119

7895225

7895472

7895509

7896054

8109975

8180407

8180408

8180409

88066_s_at

A_14_P116462

A_14_P127485

A_23_P214037

A_24_P188941

GE79895

GO:0000055

GO:0000056

GO:0001046

GO:0001558

GO:0001652

GO:0003676

GO:0003677

GO:0003682

GO:0003713

GO:0003723

GO:0004860

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005840

GO:0005856

GO:0005925

GO:0006281

GO:0006325

GO:0006334

GO:0006338

GO:0006351

GO:0006355

GO:0006407

GO:0006884

GO:0006886

GO:0006913

GO:0007010

GO:0007098

GO:0007165

GO:0008104

GO:0008284

GO:0008285

GO:0010608

GO:0010629

GO:0010824

GO:0010825

GO:0010826

GO:0012501

GO:0015934

GO:0015935

GO:0016020

GO:0016071

GO:0016607

GO:0019843

GO:0019901

GO:0023052

GO:0030957

GO:0031328

GO:0031398

GO:0031616

GO:0031647

GO:0032071

GO:0032991

GO:0032993

GO:0034644

GO:0036211

GO:0042254

GO:0042255

GO:0042273

GO:0042274

GO:0042393

GO:0042802

GO:0042803

GO:0043023

GO:0043024

GO:0043066

GO:0043226

GO:0043516

GO:0044387

GO:0045727

GO:0045893

GO:0045944

GO:0046599

GO:0048025

GO:0050821

GO:0051059

GO:0051082

GO:0051092

GO:0051726

GO:0060090

GO:0060699

GO:0060735

GO:0065003

GO:0090398

GO:0098772

GO:0140110

GO:0140297

GO:0140693

GO:1902629

GO:1902751

GO:1904751

GO:1990904

HMNXSV003029586

HMNXSV003034873

HMNXSV003056309

Hs.9614.1.A1_3p_a_at

ILMN_1678775

M23613_at

PH_hs_0030093

TC01000357.hg

TC05000942.hg

g12803184_3p_a_at

g13536990_3p_s_at

Participates

as an input of

as a component of

as an output of

Disassembly of the Rev-importin beta-B23:Ran-GTP complex (Homo sapiens)

Other forms of this molecule

monoSUMO1-K263-NPM1 [nucleoplasm]

polySUMO2,3-K263-NPM1 [nucleoplasm]

NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]

NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]

NPM1(1-117)-ALK(1068-1620) fusion [cytosol]

NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]

NPM1(1-117)-ALK(1058-1620) fusion [cytosol]

NPM1 [granular component]

NPM1 [cytosol]

p-S4-NPM1 [cytosol]

Inferred To

LOC511386 [nucleoplasm] (Bos taurus)

Nph [nucleoplasm] (Drosophila melanogaster)

NPM1 [nucleoplasm] (Bos taurus)

NPM1 [nucleoplasm] (Canis familiaris)

NPM1 [nucleoplasm] (Gallus gallus)

NPM1 [nucleoplasm] (Sus scrofa)

CG12644 [nucleoplasm] (Drosophila melanogaster)

npm1 [nucleoplasm] (Xenopus tropicalis)

Nlp [nucleoplasm] (Drosophila melanogaster)

Homologues of NPM1 [nucleoplasm] (Bos taurus)

Homologues of NPM1 [nucleoplasm] (Drosophila melanogaster)

Npm1 [nucleoplasm] (Mus musculus)

Npm1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001032827.1, NP_954654.1, NP_002511.1

OpenTargets

ENSG00000181163

HPA

ENSG00000181163-NPM1

GeneCards

P06748

Ensembl

ENSP00000428755, ENST00000393820, ENST00000517671, ENSP00000296930, ENST00000296930, ENSP00000503235, ENST00000351986, ENSP00000377408, ENSG00000181163, ENSP00000341168, ENST00000678280

PRO

P06748

Pharos - Targets

P06748

Orphanet

17401

PDB

8AH2, 2LLH, 7OBH, 2VXD, 8AS5, 7OBG, 2P1B, 5EHD

Interactors (209)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BK5 PINX1			0.81	13
UniProt:Q9H4L4 SENP3	1	SENP3 [nucleoplasm] (R-HSA-2984296)	0.78	7
UniProt:Q86SE8 NPM2	1	NPM2 [nucleoplasm] (R-HSA-9821980)	0.743	8
UniProt:O75607 NPM3			0.725	6
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.712	6
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.712	4
UniProt:Q13823 NOG2			0.706	4
UniProt:Q14684 RRP1B			0.706	5
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.706	4
UniProt:Q14137 BOP1	1	BOP1 [nucleoplasm] (R-HSA-6791206)	0.706	4
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.697	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.676	6
UniProt:Q71RC2 LARP4			0.669	3
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.664	4
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.65	3
UniProt:Q96CT7 CC124			0.649	8
UniProt:Q14690 PDCD11	1	PDCD11 [nucleoplasm] (R-HSA-6790646)	0.643	3
UniProt:Q9BZE4 GTPB4			0.643	4
UniProt:P61313 RPL15	1	RPL15 [cytosol] (R-HSA-72416)	0.643	3
UniProt:Q15397 PUM3			0.643	4
UniProt:P46781 RPS9	2	RPS9 [nucleoplasm] (R-HSA-6790663) RPS9 [cytosol] (R-HSA-72387)	0.643	3
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.64	3
UniProt:B1Q2W9 B1Q2W9			0.639	8
UniProt:P24938 CORE5			0.623	4
UniProt:Q6UPD4 Q6UPD4			0.619	4
UniProt:Q14692 BMS1	1	BMS1 [nucleoplasm] (R-HSA-6790720)	0.615	3
UniProt:Q9ULW3 ABT1			0.615	3
UniProt:P05386 RPLP1	1	RPLP1 [cytosol] (R-HSA-72398)	0.615	3
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.615	3
UniProt:Q9NRX1 PNO1	2	PNO1 [nucleoplasm] (R-HSA-6791540) PNO1 [cytosol] (R-HSA-6791509)	0.615	3
UniProt:Q9GZL7 WDR12	1	WDR12 [nucleoplasm] (R-HSA-6791215)	0.615	3
UniProt:P42696 RBM34			0.615	4
UniProt:O15226 NKRF			0.615	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	15
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.615	3
UniProt:Q9H6F5 CCD86			0.615	3
UniProt:Q9Y3C1 NOP16			0.615	4
UniProt:Q15050 RRS1			0.615	4
UniProt:O00566 MPHOSPH10	1	MPHOSPH10 [nucleoplasm] (R-HSA-6790661)	0.615	3
UniProt:O15381 NVL			0.615	3
UniProt:O96028 NSD2	2	p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984) WHSC1 [nucleoplasm] (R-HSA-1183215)	0.615	3
UniProt:Q12788 TBL3	1	TBL3 [nucleoplasm] (R-HSA-6790620)	0.615	3
UniProt:Q9Y3B9 RRP15			0.615	3
UniProt:Q6PK04 CC137			0.615	3
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.615	3
UniProt:Q96GQ7 DDX27			0.615	4
UniProt:Q9BYG3 MK67I			0.615	3
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.615	4
UniProt:Q9BQ39 DDX50			0.615	3
UniProt:P19525 EIF2AK2	5	p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) p-EIF2AK2 [cytosol] (R-HSA-9833834) EIF2AK2 [cytosol] (R-HSA-168699)	0.602	4
UniProt:Q9BZQ8 NIBA1			0.602	7
UniProt:Q9BXL5 HEMGN			0.599	7
UniProt:P49450 CENPA	2	CENPA [nucleoplasm] (R-HSA-606322) CENPA [cytosol] (R-HSA-375317)	0.597	4
UniProt:P68951 NP			0.591	5
UniProt:P05549 TFAP2A	1	TFAP2A [nucleoplasm] (R-HSA-8864280)	0.591	6
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.59	2
UniProt:P0DOE7 M	5	p-S95,T205-M [cytosol] (R-RSY-9831678) p-S95,T205-M [nucleoplasm] (R-RSY-9831706) M [nucleoplasm] (R-RSY-9831711) Nascent M [cytosol] (R-RSY-9828672) p-S95,T205-M [viral tegument] (R-RSY-9836531)	0.576	3
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.576	5
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.571	2
UniProt:Q9NX58 LYAR			0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.564	2
UniProt:Q8N726 CDKN2A	12	p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [cytosol] (R-HSA-9645669) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.564	2
UniProt:P49207 RPL34	1	RPL34 [cytosol] (R-HSA-72458)	0.564	2
UniProt:Q92876 KLK6			0.556	3
UniProt:P10176 COX8A	1	COX8A [mitochondrial inner membrane] (R-HSA-164313)	0.556	3
UniProt:Q86SE8-2 NPM2			0.556	5
UniProt:P03427 PB2			0.547	3
UniProt:Q8N3Z6 ZCHC7			0.536	2
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.536	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.532	3
UniProt:O76021 RL1D1			0.527	2
UniProt:Q92522 H1X			0.527	2
UniProt:Q6PGP7 SKIC3	1	TTC37 [cytosol] (R-HSA-8931541)	0.527	2
UniProt:P62263 RPS14	2	RPS14 [nucleoplasm] (R-HSA-6790669) RPS14 [cytosol] (R-HSA-72333)	0.527	2
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	2
UniProt:Q9HCM4 EPB41L5	1	EPB41L5 [cytosol] (R-HSA-6797564)	0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	3
UniProt:P39019 RPS19	2	RPS19 [nucleoplasm] (R-HSA-6798710) RPS19 [cytosol] (R-HSA-72343)	0.527	2
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.527	2
UniProt:P63220 RPS21	2	RPS21 [nucleoplasm] (R-HSA-6798732) RPS21 [cytosol] (R-HSA-72351)	0.527	2
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	6
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.527	2
UniProt:P60866 RPS20	2	RPS20 [nucleoplasm] (R-HSA-6798727) RPS20 [cytosol] (R-HSA-72349)	0.527	2
UniProt:Q5JTH9 RRP12			0.527	2
UniProt:Q6P158 DHX57			0.527	2
UniProt:Q49A26 GLYR1			0.527	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	2
UniProt:Q71UM5 RPS27L	2	RPS27L [nucleoplasm] (R-HSA-6791197) RPS27L [cytosol] (R-HSA-8868849)	0.527	2
UniProt:Q14694 USP10	3	USP10 [nucleoplasm] (R-HSA-3222218) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [cytosol] (R-HSA-6782974)	0.527	2
UniProt:P62861 FAU	2	FAU [nucleoplasm] (R-HSA-6798717) FAU [cytosol] (R-HSA-72371)	0.527	2
UniProt:Q969S3 ZN622			0.527	2
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	3
UniProt:Q9GZR2 REXO4			0.527	3
UniProt:P46013 KI67			0.527	2
UniProt:O75818 RPP40	1	RPP40 [nucleoplasm] (R-HSA-5696801)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P15880 RPS2	3	RPS2 [nucleoplasm] (R-HSA-6790655) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.527	2
UniProt:P35251 RFC1	1	RFC1 [nucleoplasm] (R-HSA-68435)	0.527	2
UniProt:Q9P287 BCCIP			0.527	2
UniProt:P62857 RPS28	2	RPS28 [nucleoplasm] (R-HSA-6791202) RPS28 [cytosol] (R-HSA-72365)	0.527	2
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:Q99613 EIF3C	1	EIF3C [cytosol] (R-HSA-72550)	0.527	2
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.527	2
UniProt:Q9NXF1 TEX10	1	TEX10 [nucleoplasm] (R-HSA-3826589)	0.527	3
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.527	2
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.527	2
UniProt:O00567 NOP56	2	NOP56 [nucleoplasm] (R-HSA-6790696) NOP56 [cytosol] (R-HSA-391293)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	2
UniProt:Q7Z478 DHX29			0.527	2
UniProt:P35268 RPL22	1	RPL22 [cytosol] (R-HSA-72428)	0.527	2
UniProt:Q06787 FMR1			0.527	3
UniProt:O75683 SURF6			0.527	3
UniProt:P62750 RPL23A	1	RPL23A [cytosol] (R-HSA-72432)	0.527	3
UniProt:O76094 SRP72	1	SRP72 [cytosol] (R-HSA-265069)	0.527	2
UniProt:Q8TDN6 BRX1			0.527	3
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	3
UniProt:Q14152 EIF3A	1	EIF3A [cytosol] (R-HSA-72546)	0.527	2
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.527	2
UniProt:O95707 POP4	1	POP4 [nucleoplasm] (R-HSA-5696789)	0.527	3
UniProt:Q15477 SKIC2	1	SKIV2L [cytosol] (R-HSA-391294)	0.527	2
UniProt:Q9UNX4 WDR3	1	WDR3 [nucleoplasm] (R-HSA-6790724)	0.527	2
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.527	2
UniProt:Q96HI0 SENP5	1	SENP5 [nucleoplasm] (R-HSA-2984297)	0.527	3
UniProt:Q8TDD1 DDX54			0.527	3
UniProt:P46783 RPS10	2	RPS10 [nucleoplasm] (R-HSA-6798733) RPS10 [cytosol] (R-HSA-72325)	0.527	2
UniProt:P46782 RPS5	2	RPS5 [nucleoplasm] (R-HSA-6791188) RPS5 [cytosol] (R-HSA-72379)	0.527	2
UniProt:O60264 SMARCA5	1	SMARCA5 [nucleoplasm] (R-HSA-417140)	0.527	2
UniProt:Q9H7B2 RPF2			0.527	2
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.527	2
UniProt:Q99575 POP1	1	POP1 [nucleoplasm] (R-HSA-5696802)	0.527	2
UniProt:P78346 RPP30	1	RPP30 [nucleoplasm] (R-HSA-5696779)	0.527	2
UniProt:Q7KZF4 SND1	2	SND1(1-593)-BRAF(381-766) fusion [cytosol] (R-HSA-6802469) SND1(1-593)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802552)	0.527	2
UniProt:Q9Y4W2 LAS1L	1	LAS1L [nucleoplasm] (R-HSA-6791521)	0.527	2
UniProt:Q6NW34 NEPRO			0.527	3
UniProt:P40429 RPL13A	2	p-RPL13A [cytosol] (R-HSA-156829) RPL13A [cytosol] (R-HSA-72412)	0.527	2
UniProt:Q6DKI1 RL7L			0.527	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.524	2
UniProt:Q98147 Q98147			0.524	2
UniProt:Q14684-1 RRP1B			0.512	4
UniProt:Q10570 CPSF1	1	CPSF1 [nucleoplasm] (R-HSA-71989)	0.499	2
UniProt:Q9UQ80 PA2G4	2	PA2G4 [extracellular region] (R-HSA-6806200) PA2G4 [azurophil granule lumen] (R-HSA-6799205)	0.491	3
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.489	3
UniProt:Q8N8A6 DDX51			0.483	2
UniProt:Q8NHQ9 DDX55			0.483	3
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.483	2
UniProt:Q9BXY0 MAK16			0.483	3
UniProt:Q68D10 SPT2			0.483	2
UniProt:Q8N9T8 KRI1			0.483	2
UniProt:P48634 PRC2A			0.483	2
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.483	2
UniProt:Q08J23 NSUN2	1	NSUN2 [nucleoplasm] (R-HSA-6782382)	0.483	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.483	2
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.483	2
UniProt:Q9BRJ6 CG050			0.483	2
UniProt:P19784 CSNK2A2	2	CSNK2A2 [nucleoplasm] (R-HSA-6805065) CSNK2A2 [cytosol] (R-HSA-201721)	0.483	2
UniProt:O95793 STAU1			0.483	2
UniProt:Q9H501 ESF1			0.483	2
UniProt:Q6MZP7 LIN54	1	LIN54 [nucleoplasm] (R-HSA-389103)	0.483	2
UniProt:Q8NEJ9 NGDN			0.483	2
UniProt:Q9NZM5 NOP53			0.483	3
UniProt:Q9NVU7 SDA1			0.483	2
UniProt:P35250 RFC2	1	RFC2 [nucleoplasm] (R-HSA-68433)	0.483	2
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.483	2
UniProt:Q9H6Y2 WDR55			0.483	2
UniProt:Q9BSC4 NOL10			0.483	2
UniProt:Q5QJE6 TDIF2			0.483	2
UniProt:Q9ULJ3 ZBT21			0.483	2
UniProt:Q96B26 EXOSC8	2	EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [cytosol] (R-HSA-429912)	0.483	2
UniProt:Q8IY37 DHX37	1	DHX37 [nucleoplasm] (R-HSA-6790668)	0.483	2
UniProt:Q14781 CBX2	1	CBX2 [nucleoplasm] (R-HSA-389110)	0.483	2
UniProt:Q2TB10 ZN800			0.483	3
UniProt:Q96L73 NSD1	1	NSD1 [nucleoplasm] (R-HSA-1183232)	0.483	2
UniProt:Q13206 DDX10			0.483	2
UniProt:O95639 CPSF4	1	CPSF4 [nucleoplasm] (R-HSA-169104)	0.483	2
UniProt:Q9H9L3 ISG20L2	1	ISG20L2 [nucleoplasm] (R-HSA-6799476)	0.483	2
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.483	2
UniProt:Q02880 TOP2B	2	monoSUMO1-K-TOP2B [nucleoplasm] (R-HSA-4641297) TOP2B [nucleoplasm] (R-HSA-4641359)	0.483	2
UniProt:O95625 ZBT11			0.483	2
UniProt:Q9BRD0 BUD13	1	BUD13 [nucleoplasm] (R-HSA-9769522)	0.483	3
UniProt:Q86U86 PBRM1	1	PBRM1 [nucleoplasm] (R-HSA-389254)	0.483	2
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.483	2
UniProt:Q8WYP5 AHCTF1	1	AHCTF1 [cytosol] (R-HSA-376244)	0.483	2
UniProt:Q03188 CENPC	2	CENPC [nucleoplasm] (R-HSA-5633512) CENPC1 [cytosol] (R-HSA-375292)	0.483	2
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.483	2
UniProt:Q9Y2R4 DDX52	1	DDX52 [nucleoplasm] (R-HSA-6790703)	0.483	2
UniProt:Q9Y4C8 RBM19			0.483	2
UniProt:Q86VM9 ZCH18			0.483	3
UniProt:Q14966 ZNF638	1	ZNF638 [nucleoplasm] (R-HSA-8939429)	0.483	2
UniProt:Q12789 GTF3C1	1	GTF3C1 [nucleoplasm] (R-HSA-83697)	0.483	2
UniProt:Q9BVJ6 UTP14A	1	UTP14A [nucleoplasm] (R-HSA-6790695)	0.483	2
UniProt:O00541 PES1	1	PES1 [nucleoplasm] (R-HSA-6791207)	0.483	2
UniProt:Q9Y676 MRPS18B	1	MRPS18B [mitochondrial inner membrane] (R-HSA-5368234)	0.483	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.483	2
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.483	2
UniProt:Q9NUL3 STAU2			0.483	2
UniProt:Q03701 CEBPZ			0.483	2
UniProt:Q9NQT5 EXOSC3	2	EXOSC3 [nucleoplasm] (R-HSA-6791572) EXOSC3 [cytosol] (R-HSA-430017)	0.483	2
UniProt:Q8NDF8 PAPD5			0.483	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.483	2
UniProt:Q8NFW8 CMAS	1	CMAS [nucleoplasm] (R-HSA-4085417)	0.483	2
UniProt:P78344 EIF4G2	1	EIF4G2 [cytosol] (R-HSA-1678826)	0.483	2
UniProt:P78345 RPP38	1	RPP38 [nucleoplasm] (R-HSA-5696791)	0.483	3
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.483	2
UniProt:Q9UIG0 BAZ1B	1	BAZ1B [nucleoplasm] (R-HSA-417153)	0.483	2
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.483	2
UniProt:Q8IUH3 RBM45			0.462	2
UniProt:P11387 TOP1	2	monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.462	3

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