Reactome | CENPA [nucleoplasm]

CENPA [nucleoplasm]

Stable Identifier

R-HSA-606322

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CENP-A, Histone H3-like centromeric protein A, CENPA_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P49450 CENPA

Gene Names

CENPA

Chain

initiator methionine:1, chain:2-140

Reference Genes

BioGPS Gene:1058 CENPA

COSMIC (genes):CENPA CENPA

CTD Gene:1058 CENPA

dbSNP Gene:1058 CENPA

ENSEMBL:ENSG00000115163 CENPA

ENSEMBL:ENSG00000115163.15 CENPA

HGNC:1851 CENPA

KEGG Gene (Homo sapiens):1058 CENPA

Monarch:1058 CENPA

NCBI Gene:1058 CENPA

OMIM:117139 CENPA

UCSC:P49450 CENPA

Reference Transcript

Other Identifiers

1058

11723565_a_at

11727916_a_at

11745571_a_at

11758529_s_at

16877956

204962_PM_s_at

204962_s_at

210821_PM_x_at

210821_x_at

2473994

2473995

2473996

2473998

2473999

2474000

2474001

2474002

2474003

2474004

2474005

527_at

8040712

A_14_P101460

A_24_P413884

GE58267

GO:0000132

GO:0000278

GO:0000281

GO:0000775

GO:0000779

GO:0000785

GO:0000786

GO:0000910

GO:0003677

GO:0003682

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005721

GO:0005829

GO:0006325

GO:0007010

GO:0007049

GO:0007163

GO:0030527

GO:0034080

GO:0043226

GO:0043505

GO:0046982

GO:0051301

GO:0051382

GO:0061638

GO:0061644

GO:0065003

GO:0071459

HMNXSV003028236

ILMN_1801257

ILMN_2392472

PH_hs_0000216

PH_hs_0035316

TC02004917.hg

U14518_at

g12803732_3p_a_at

g4585861_3p_a_at

Participates

as a component of

Other forms of this molecule

CENPA [cytosol]

Inferred To

Ghost homologue of CENPA [nucleoplasm] (Gallus gallus)

cenpa [nucleoplasm] (Danio rerio)

cenpa [nucleoplasm] (Xenopus tropicalis)

CENPA [nucleoplasm] (Bos taurus)

CENPA [nucleoplasm] (Canis familiaris)

CENPA [nucleoplasm] (Sus scrofa)

Cenpa [nucleoplasm] (Mus musculus)

Cenpa [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001800.1, NP_001035891.1

OpenTargets

ENSG00000115163

HPA

ENSG00000115163-CENPA

GeneCards

P49450

Ensembl

ENSP00000336868, ENST00000233505, ENSP00000233505, ENST00000335756, ENSG00000115163

PRO

P49450

Pharos - Targets

P49450

PDB

6O1D, 7U46, 6SEE, 5CVD, 7U47, 7PII, 6MUO, 6SEF, 7D20, 6SEG, 6MUP, 7U4D, 3AN2, 3R45, 7YYH, 6SE0, 6E0C, 6BUZ, 3WTP, 6TEM, 3NQJ, 7YWX, 6C0W, 6SE6, 6KDQ, 6L49, 5Z23, 6E0P, 6KDS, 7R5R, 3NQU

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.793	6
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.597	4
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.576	3
UniProt:Q96CV9 OPTN	5	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907)	0.556	3

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