Reactome | OPRM1 [plasma membrane]

OPRM1 [plasma membrane]

Stable Identifier

R-HSA-60951

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Mu-type opioid receptor, MOR-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P35372 OPRM1

Gene Names

OPRM1, MOR1

Chain

chain:1-400

Reference Genes

BioGPS Gene:4988 OPRM1

COSMIC (genes):OPRM1 OPRM1

CTD Gene:4988 OPRM1

dbSNP Gene:4988 OPRM1

ENSEMBL:ENSG00000112038 OPRM1

HGNC:8156 OPRM1

KEGG:hsa:4988 OPRM1

Monarch:4988 OPRM1

NCBI Gene:4988 OPRM1

OMIM:600018 OPRM1

UCSC:P35372 OPRM1

Reference Transcript

Participates

as a member of

as an output of

as an input of

Opioid binds MOR (Homo sapiens)

as a component of

Opioid:MOR [plasma membrane] (Homo sapiens)

Inferred To

npr-16 [plasma membrane] (Caenorhabditis elegans)

npr-26 [plasma membrane] (Caenorhabditis elegans)

AstC-R1 [plasma membrane] (Drosophila melanogaster)

oprm1 [plasma membrane] (Xenopus tropicalis)

AstC-R2 [plasma membrane] (Drosophila melanogaster)

OPRM1 [plasma membrane] (Bos taurus)

OPRM1 [plasma membrane] (Caenorhabditis elegans)

OPRM1 [plasma membrane] (Canis familiaris)

OPRM1 [plasma membrane] (Gallus gallus)

OPRM1 [plasma membrane] (Sus scrofa)

npr-23 [plasma membrane] (Caenorhabditis elegans)

Rh7 [plasma membrane] (Drosophila melanogaster)

Homologues of OPRM1 [plasma membrane] (Caenorhabditis elegans)

Homologues of OPRM1 [plasma membrane] (Drosophila melanogaster)

npr-24 [plasma membrane] (Caenorhabditis elegans)

npr-28 [plasma membrane] (Caenorhabditis elegans)

npr-18 [plasma membrane] (Caenorhabditis elegans)

Oprm1 [plasma membrane] (Mus musculus)

Oprm1 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_016866395.1, NP_001272452.1, NP_001272457.1, NP_001138753.1, NP_001138758.1, NP_001138754.1, NP_001008505.2, NP_001138759.1, NP_001008504.2, NP_000905.3, NP_001008503.2, NP_001138755.1, NP_001138751.1, NP_001138756.1, NP_001272455.1, NP_001138752.1, NP_001138757.1, NP_001272456.1, NP_001272453.1

Guide to Pharmacology - Targets

319

OpenTargets

ENSG00000112038

ENSEMBL

ENSP00000399359, ENSP00000403549, ENSP00000429719, ENSP00000394624, ENST00000518759, ENST00000452687, ENST00000522739, ENSP00000430260, ENST00000428397, ENST00000524150, ENST00000330432, ENST00000522555, ENST00000522236, ENST00000337049, ENST00000414028, ENSP00000338381, ENSP00000413752, ENSP00000429373, ENSP00000229768, ENSG00000112038, ENSP00000431048, ENST00000520708, ENSP00000430575, ENST00000434900, ENST00000435918, ENSP00000430876, ENSP00000428018, ENSP00000430097, ENSP00000328264, ENST00000519083, ENST00000524163, ENST00000229768, ENST00000419506, ENSP00000410497, ENSP00000411903

ZINC - FDA approved

OPRM_HUMAN

ZINC - Substances

OPRM_HUMAN

ZINC - Biogenic

OPRM_HUMAN

ZINC target

P35372

PRO

P35372

GlyGen

P35372

PDB

8EFO, 8EFQ, 8EFL, 8EF6, 8F7R, 8K9K, 8EFB, 8EF5, 8K9L, 8F7Q

ZINC - Investigational

OPRM_HUMAN

ZINC - Metabolites

OPRM_HUMAN

GeneCards

OPRM1

HPA

ENSG00000112038-OPRM1

Pharos - Targets

P35372

ZINC - Predictions - Purchasable

OPRM_HUMAN

HMDB Protein

HMDBP02643

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5T9L3 WLS	5	WLS [extracellular exosome] (R-HSA-3781960) WLS [endocytic vesicle membrane] (R-HSA-3781954) WLS [early endosome membrane] (R-HSA-3247745) WLS [Golgi membrane] (R-HSA-3247747) WLS [plasma membrane] (R-HSA-3247746)	0.819	11
UniProt:Q96S59 RANBP9	1	RANBP9 [cytosol] (R-HSA-374586)	0.69	5
UniProt:Q9P0L0 VAPA	4	VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920)	0.675	4
UniProt:P35212 GJA4	1	GJA4 [endoplasmic reticulum membrane] (R-HSA-190657)	0.635	3
UniProt:P21333 FLNA	3	FLNA [cytosol] (R-HSA-210019) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [extracellular region] (R-HSA-350712)	0.602	5
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.581	4
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.581	5
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.581	4
UniProt:Q9Y679 AUP1			0.581	4
UniProt:Q15942 ZYX			0.508	2
UniProt:O43255 SIAH2	1	SIAH2 [cytosol] (R-HSA-374566)	0.508	3
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.508	2
UniProt:Q9H3M0 KCNF1	1	KCNF1 [plasma membrane] (R-HSA-977450)	0.488	2

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