Reactome | PDPK1 [plasma membrane]

PDPK1 [plasma membrane]

Stable Identifier

R-HSA-61459

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PDK1, 3-phosphoinositide dependent protein kinase-1

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Locations in the PathwayBrowser for interactor UniProt:P35052 GPC1

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 binds PIP3 (Homo sapiens)
        
        PDPK1 [plasma membrane] (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 binds PIP3 (Homo sapiens)
        
        PDPK1 [plasma membrane] (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - VEGFR2 mediated cell proliferation (Homo sapiens)
        
        PDK1 phosphorylates PKC (Homo sapiens)
        
        PDPK1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15530 PDPK1

Gene Names

PDPK1, PDK1

Chain

chain:1-556

Reference Genes

COSMIC (genes):PDK1 PDPK1

COSMIC (genes):PDPK1 PDPK1

dbSNP Gene:5170 PDPK1

ENSEMBL:ENSG00000140992 PDPK1

Participates

as a member of

AKT1/PDK1 [plasma membrane] (Homo sapiens)

as a component of

as an input of

Other forms of this molecule

p-S241-PDPK1 [cytosol]

PDPK1 [cytosol]

Inferred To

PDPK1 [plasma membrane] (Bos taurus)

PDPK1 [plasma membrane] (Caenorhabditis elegans)

PDPK1 [plasma membrane] (Canis familiaris)

PDPK1 [plasma membrane] (Danio rerio)

PDPK1 [plasma membrane] (Dictyostelium discoideum)

PDPK1 [plasma membrane] (Drosophila melanogaster)

PDPK1 [plasma membrane] (Gallus gallus)

PDPK1 [plasma membrane] (Mus musculus)

PDPK1 [plasma membrane] (Plasmodium falciparum)

PDPK1 [plasma membrane] (Rattus norvegicus)

PDPK1 [plasma membrane] (Saccharomyces cerevisiae)

PDPK1 [plasma membrane] (Schizosaccharomyces pombe)

PDPK1 [plasma membrane] (Sus scrofa)

PDPK1 [plasma membrane] (Xenopus tropicalis)

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.767	4
UniProt:Q9Y4P3 TBL2			0.623	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.564	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.544	3
UniProt:P55084 HADHB	1	HADHB [mitochondrial inner membrane] (R-HSA-77266)	0.527	3
UniProt:P18827 SDC1	20	HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666) HS(1)-SDC1 [plasma membrane] (R-HSA-2076672) HS(3)-SDC1 [plasma membrane] (R-HSA-2076691) HS(5)-SDC1 [plasma membrane] (R-HSA-2076626) SDC1 [plasma membrane] (R-HSA-174758) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) SDC1 [Golgi lumen] (R-HSA-2054105) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064247) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064082) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) HS(4)-SDC1 [Golgi lumen] (R-HSA-2076593) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314) Heparan(2)-SDC1 [Golgi lumen] (R-HSA-2076558) Heparan(1)-SDC1 [Golgi lumen] (R-HSA-2076349)	0.527	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:Q92896 GLG1	1	GLG1 [plasma membrane] (R-HSA-2870220)	0.527	3
UniProt:P09038 FGF2	1	FGF2(10-155) [extracellular region] (R-HSA-189898)	0.527	2
UniProt:P31431 SDC4	20	HS(4)-SDC4 [plasma membrane] (R-HSA-2076670) HS(6)-SDC4 [plasma membrane] (R-HSA-2076633) HS(2)-SDC4 [plasma membrane] (R-HSA-2076694) HS(1)-SDC4 [plasma membrane] (R-HSA-2076653) HS(3)-SDC4 [plasma membrane] (R-HSA-2076674) HS(5)-SDC4 [plasma membrane] (R-HSA-2076635) XylS-SDC4 [Golgi lumen] (R-HSA-2064195) Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064249) SDC4 [Golgi lumen] (R-HSA-2054111) Gal-Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064100) GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064067) HS(3)-SDC4 [Golgi lumen] (R-HSA-2076418) HS(4)-SDC4 [Golgi lumen] (R-HSA-2076407) HS(2)-SDC4 [Golgi lumen] (R-HSA-2076411) HS(1)-SDC4 [Golgi lumen] (R-HSA-2076434) Heparan(4)-SDC4 [Golgi lumen] (R-HSA-2076613) Heparan(3)-SDC4 [Golgi lumen] (R-HSA-2076460) Heparan(2)-SDC4 [Golgi lumen] (R-HSA-2076446) Heparan(1)-SDC4 [Golgi lumen] (R-HSA-2076394) Heparan-SDC4 [Golgi lumen] (R-HSA-2076374)	0.527	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	4
UniProt:O75116 ROCK2	2	ROCK2 [cytosol] (R-HSA-419058) Activated ROCK2 [cytosol] (R-HSA-4687775)	0.527	2
UniProt:Q6A1A2 PDPK2			0.527	3
UniProt:O75487 GPC4	20	HS(4)-GPC4 [plasma membrane] (R-HSA-2076638) HS(6)-GPC4 [plasma membrane] (R-HSA-2076677) HS(2)-GPC4 [plasma membrane] (R-HSA-2076662) HS(1)-GPC4 [plasma membrane] (R-HSA-2076673) HS(3)-GPC4 [plasma membrane] (R-HSA-2076697) HS(5)-GPC4 [plasma membrane] (R-HSA-2076658) XylS-GPC4 [Golgi lumen] (R-HSA-2064173) Gal-Xyl-GPC4 [Golgi lumen] (R-HSA-2064060) GPC4 [Golgi lumen] (R-HSA-2054108) Gal-Gal-Xyl-GPC4 [Golgi lumen] (R-HSA-2064030) GlcA-Gal-Gal-Xyl-GPC4 [Golgi lumen] (R-HSA-2064215) HS(3)-GPC4 [Golgi lumen] (R-HSA-2076439) HS(4)-GPC4 [Golgi lumen] (R-HSA-2076368) HS(2)-GPC4 [Golgi lumen] (R-HSA-2076336) HS(1)-GPC4 [Golgi lumen] (R-HSA-2076401) Heparan(4)-GPC4 [Golgi lumen] (R-HSA-2076440) Heparan(3)-GPC4 [Golgi lumen] (R-HSA-2076612) Heparan(2)-GPC4 [Golgi lumen] (R-HSA-2076555) Heparan(1)-GPC4 [Golgi lumen] (R-HSA-2076560) Heparan-GPC4 [Golgi lumen] (R-HSA-2076475)	0.527	2
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.527	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.527	3
UniProt:Q9BZF1 OSBPL8	1	OSBPL8 [cytosol] (R-HSA-8867870)	0.527	2
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.527	3
UniProt:P35052 GPC1	20	HS(4)-GPC1 [plasma membrane] (R-HSA-2076668) HS(6)-GPC1 [plasma membrane] (R-HSA-2076629) HS(2)-GPC1 [plasma membrane] (R-HSA-2076632) HS(1)-GPC1 [plasma membrane] (R-HSA-2076645) HS(3)-GPC1 [plasma membrane] (R-HSA-2076636) HS(5)-GPC1 [plasma membrane] (R-HSA-2076648) GPC1 [plasma membrane] (R-HSA-425952) XylS-GPC1 [Golgi lumen] (R-HSA-2064041) Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064076) GPC1 [Golgi lumen] (R-HSA-2054106) Gal-Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064144) GlcA-Gal-Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064189) HS(3)-GPC1 [Golgi lumen] (R-HSA-2076340) HS(4)-GPC1 [Golgi lumen] (R-HSA-2076502) HS(2)-GPC1 [Golgi lumen] (R-HSA-2076296) HS(1)-GPC1 [Golgi lumen] (R-HSA-2076424) Heparan(4)-GPC1 [Golgi lumen] (R-HSA-2076605) Heparan(3)-GPC1 [Golgi lumen] (R-HSA-2076503) Heparan(2)-GPC1 [Golgi lumen] (R-HSA-2076501) Heparan(1)-GPC1 [Golgi lumen] (R-HSA-2076476)	0.527	2
UniProt:O00468 AGRN	20	HS(4)-AGRN [plasma membrane] (R-HSA-2076654) HS(6)-AGRN [plasma membrane] (R-HSA-2076678) HS(2)-AGRN [plasma membrane] (R-HSA-2076686) HS(1)-AGRN [plasma membrane] (R-HSA-2076634) HS(3)-AGRN [plasma membrane] (R-HSA-2076663) HS(5)-AGRN [plasma membrane] (R-HSA-2076642) AGRN(30-2045) [extracellular region] (R-HSA-375056) XylS-AGRN(30-2045) [Golgi lumen] (R-HSA-2064220) Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064130) AGRN(30-2045) [Golgi lumen] (R-HSA-2054104) Gal-Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064040) GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064200) HS(3)-AGRN [Golgi lumen] (R-HSA-2076493) HS(4)-AGRN [Golgi lumen] (R-HSA-2076337) HS(2)-AGRN [Golgi lumen] (R-HSA-2076521) HS(1)-AGRN [Golgi lumen] (R-HSA-2076350) Heparan(4)-AGRN [Golgi lumen] (R-HSA-2076300) Heparan(3)-AGRN [Golgi lumen] (R-HSA-2076569) Heparan(2)-AGRN [Golgi lumen] (R-HSA-2076301) Heparan(1)-AGRN [Golgi lumen] (R-HSA-2076317)	0.527	2
UniProt:P34741 SDC2	20	HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) SDC2 [Golgi lumen] (R-HSA-2054101) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397)	0.527	2
UniProt:Q00005 2ABB			0.524	8
UniProt:O95704 APBB3			0.488	2
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.488	2