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PLCB1 [cytosol]
Stable Identifier
R-HSA-61693
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PLC beta 1, Phosphoinositide phospholipase C, PLC-beta-1, Phospholipase C-beta-1, PLC-I, PLC-154, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1, KIAA0581
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
PLCbz [cytosol] (Homo sapiens)
PLCB1:Ca2+ [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Acetylcholine regulates insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
Gq alpha activates Phospholipase C beta (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
Free fatty acids regulate insulin secretion (Homo sapiens)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
Gq alpha activates Phospholipase C beta (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of kainate receptors upon glutamate binding (Homo sapiens)
Presynaptic function of Kainate receptors (Homo sapiens)
Activation of GRIK3 homomer (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
Kainate receptor-glutamate-Gprotein complex [plasma membrane] (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Activation of PLC beta-1/4 (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
Inactivation of PLC beta (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
PLC beta is activated by G alpha (q) (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through PLC beta (Homo sapiens)
Gbeta:gamma activation of PLC beta (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Gbeta:gamma activation of PLC beta (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQ66 PLCB1
Gene Names
PLCB1, KIAA0581
Chain
chain:1-1216
Reference Genes
BioGPS Gene:23236 PLCB1
COSMIC (genes):PLCB1 PLCB1
CTD Gene:23236 PLCB1
dbSNP Gene:23236 PLCB1
ENSEMBL:ENSG00000182621 PLCB1
ENSEMBL_homo_sapiens_GENE:ENSG00000182621.19 PLCB1
HGNC:15917 PLCB1
KEGG Gene (Homo sapiens):23236 PLCB1
Monarch:23236 PLCB1
NCBI Gene:23236 PLCB1
OMIM:607120 PLCB1
UCSC:Q9NQ66 PLCB1
Reference Transcript
RefSeq:NM_015192.3 PLCB1
RefSeq:NM_182734.2 PLCB1
Other Identifiers
11730106_a_at
11730107_a_at
11730573_x_at
16911283
211925_PM_s_at
211925_s_at
213222_PM_at
213222_at
215687_PM_x_at
215687_x_at
23236
35980_at
3875644
3875645
3875646
3875647
3875648
3875656
3875694
3875752
3875755
3875756
3875757
3875758
3875769
3875770
3875771
3875784
3875787
3875788
3875790
3875791
3875794
3875795
3875796
3875797
3875798
3875799
3875800
3875801
3875802
3875806
3875807
3875808
3875809
3875811
3875812
3875813
3875815
3875823
3875824
3875840
3875841
3875842
3875843
8060854
A_14_P101690
A_14_P120757
A_14_P123700
A_23_P6099
A_24_P941643
GE53290
GO:0000086
GO:0000278
GO:0000785
GO:0002376
GO:0003824
GO:0004435
GO:0004629
GO:0005096
GO:0005509
GO:0005515
GO:0005516
GO:0005521
GO:0005546
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006629
GO:0007165
GO:0007186
GO:0007200
GO:0007207
GO:0007213
GO:0007215
GO:0007612
GO:0007613
GO:0008081
GO:0008277
GO:0008289
GO:0010243
GO:0016020
GO:0016042
GO:0016607
GO:0016787
GO:0019899
GO:0021987
GO:0022414
GO:0023052
GO:0030154
GO:0031161
GO:0031965
GO:0032024
GO:0032735
GO:0032957
GO:0032991
GO:0034284
GO:0035556
GO:0035722
GO:0035723
GO:0040019
GO:0042802
GO:0043226
GO:0043434
GO:0045444
GO:0045663
GO:0045892
GO:0045893
GO:0046330
GO:0046488
GO:0048009
GO:0048015
GO:0048639
GO:0048856
GO:0048870
GO:0050877
GO:0051209
GO:0055065
GO:0055085
GO:0060466
GO:0070062
GO:0070498
GO:0080154
GO:0098772
GO:0098978
GO:0098982
GO:0099105
GO:0099170
GO:0099178
GO:0099524
GO:0140013
GO:1900087
GO:1901135
GO:1902618
GO:1903140
GO:1904117
GO:1904637
GO:1905631
GO:1990806
GO:2000344
GO:2000438
GO:2000560
Hs.41143.0.S2_3p_at
Hs.41143.2.S1_3p_a_at
ILMN_1708432
ILMN_1723969
PH_hs_0025202
TC20000072.hg
g9438228_3p_a_at
Participates
as a candidate of
PLC beta1,2,3 [cytosol] (Homo sapiens)
as a member of
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
as a component of
PLCB1:Ca2+ [cytosol] (Homo sapiens)
Inferred To
PLC beta 1 [cytosol]
(Bos taurus)
PLCB1 [cytosol]
(Canis familiaris)
PLCB1 [cytosol]
(Dictyostelium discoideum)
PLCB1 [cytosol]
(Drosophila melanogaster)
PLCB1 [cytosol]
(Gallus gallus)
PLCB1 [cytosol]
(Plasmodium falciparum)
PLCB1 [cytosol]
(Saccharomyces cerevisiae)
PLCB1 [cytosol]
(Schizosaccharomyces pombe)
PLCB1 [cytosol]
(Sus scrofa)
PLCB1 [cytosol]
(Xenopus tropicalis)
Plcb1 [cytosol]
(Mus musculus)
Plcb1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_877398.1
,
NP_056007.1
Guide to Pharmacology - Targets
1403
OpenTargets
ENSG00000182621
IntEnz
3.1.4.11
GeneCards
Q9NQ66
HPA
ENSG00000182621-PLCB1
Ensembl
ENST00000378637
,
ENSG00000182621
,
ENSP00000367908
,
ENST00000378641
,
ENST00000338037
,
ENSP00000367904
,
ENSP00000338185
ZINC target
Q9NQ66
PRO
Q9NQ66
Pharos - Targets
Q9NQ66
Orphanet
19817
HMDB Protein
HMDBP00222
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