Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PLCB4 [cytosol]
Stable Identifier
R-HSA-61697
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PLC beta 4, Phosphoinositide phospholipase C, PLC-beta-4, Phospholipase C-beta-4, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
PLCbz [cytosol] (Homo sapiens)
PLCB4:Ca2+ [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Activation of PLC beta-1/4 (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
Inactivation of PLC beta (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
PLC beta is activated by G alpha (q) (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15147 PLCB4
Gene Names
PLCB4
Chain
initiator methionine:, chain:2-1175
Reference Genes
BioGPS Gene:5332 PLCB4
COSMIC (genes):PLCB4 PLCB4
CTD Gene:5332 PLCB4
dbSNP Gene:5332 PLCB4
ENSEMBL:ENSG00000101333 PLCB4
ENSEMBL_homo_sapiens_GENE:ENSG00000101333.19 PLCB4
HGNC:9059 PLCB4
KEGG Gene (Homo sapiens):5332 PLCB4
Monarch:5332 PLCB4
NCBI Gene:5332 PLCB4
OMIM:600810 PLCB4
UCSC:Q15147 PLCB4
Reference Transcript
RefSeq:XM_017027881.1 PLCB4
RefSeq:NM_001172646.1 PLCB4
RefSeq:NM_000933.3 PLCB4
RefSeq:XM_017027880.1 PLCB4
RefSeq:NM_182797.2 PLCB4
Other Identifiers
11738021_a_at
11743366_a_at
11743367_a_at
11755050_s_at
11756635_a_at
16911338
203895_PM_at
203895_at
203896_PM_s_at
203896_s_at
35654_at
3875904
3875909
3875910
3875915
3875922
3875932
3875943
3875944
3875945
3875956
3875959
3875963
3875964
3875965
3875969
3875970
3875972
3875973
3875974
3875975
3875978
3875979
3875982
3875988
3875990
3875994
3875996
3875999
3876006
3876007
3876008
3876013
3876014
3876016
3876017
3876018
3876019
3876021
3876023
3876024
3876027
3876028
3876036
3876039
3876040
3876041
3876042
5332
8060897
900_at
901_g_at
A_14_P122232
A_23_P28898
A_33_P3260634
A_33_P3353502
GE56091
GE80968
GO:0003824
GO:0004435
GO:0004629
GO:0005509
GO:0005515
GO:0005829
GO:0005886
GO:0006629
GO:0007165
GO:0007186
GO:0007200
GO:0008081
GO:0016042
GO:0016787
GO:0023052
GO:0035556
GO:0048015
GO:0051209
GO:0055065
GO:0055085
HMNXSV003012117
Hs.283006.0.S2_3p_at
ILMN_1736426
ILMN_2397294
L41349_at
PH_hs_0022684
TC20000076.hg
g4505866_3p_a_at
Participates
as a member of
PLC-beta [cytosol] (Homo sapiens)
as a component of
PLCB4:Ca2+ [cytosol] (Homo sapiens)
Inferred To
PLCB4 [cytosol]
(Bos taurus)
PLCB4 [cytosol]
(Caenorhabditis elegans)
PLCB4 [cytosol]
(Canis familiaris)
PLCB4 [cytosol]
(Dictyostelium discoideum)
PLCB4 [cytosol]
(Drosophila melanogaster)
PLCB4 [cytosol]
(Gallus gallus)
PLCB4 [cytosol]
(Mus musculus)
PLCB4 [cytosol]
(Plasmodium falciparum)
PLCB4 [cytosol]
(Saccharomyces cerevisiae)
PLCB4 [cytosol]
(Schizosaccharomyces pombe)
PLCB4 [cytosol]
(Sus scrofa)
Plcb4 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_016883369.1
,
NP_877949.2
,
NP_000924.3
,
NP_001166117.1
,
XP_016883370.1
Guide to Pharmacology - Targets
1406
OpenTargets
ENSG00000101333
GeneCards
Q15147
HPA
ENSG00000101333-PLCB4
Ensembl
ENSP00000508676
,
ENSP00000510632
,
ENSP00000508677
,
ENST00000378493
,
ENST00000693752
,
ENST00000688656
,
ENSP00000510118
,
ENST00000686313
,
ENST00000685823
,
ENST00000686976
,
ENST00000686871
,
ENSP00000367754
,
ENSP00000508650
,
ENSP00000508595
,
ENSG00000101333
,
ENSP00000509597
,
ENST00000378501
,
ENSP00000509912
,
ENSP00000508600
,
ENSP00000367762
,
ENST00000685859
,
ENST00000693005
,
ENST00000689910
,
ENSP00000510124
,
ENSP00000510302
,
ENST00000685310
,
ENST00000685110
PRO
Q15147
Pharos - Targets
Q15147
Orphanet
21158
HMDB Protein
HMDBP00223
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text