Reactome | Activated NOD1 oligomerizes

Activated NOD1 oligomerizes

Stable Identifier

R-HSA-622310

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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NOD1 is activated by iE-DAP in a LRR domain dependent manner. The LRR domain has a negative influence on NOD1 self-association (Inohara et al. 2000); binding of iE-DAP likely causes conformational changes that free the NACHT domain, allowing oligomerization and subsequent association of other proteins. Coimmunoprecipitation experiments demonstrate that NOD1 can interact with itself (Inohara et al. 1999) via the NACHT domain (Inohara et al. 2000). NACHT domains are part of the AAA+ domain family. Members of this family form hexamers or heptamers. Based on this observation, NOD1 and NOD2 are believed to form oligomers of this size (Martinon & Tschopp, 2005).

Literature References

PubMed ID	Title	Journal	Year
10329646	Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB Ni, J, Carrio, R, Yee, C, Hu, Y, Nunez, G, Koseki, T, Merino, J, Chen, S, Inohara, N, del Peso, L, Liu, D	J Biol Chem	1999