Nicotinic acetylcholine receptors are activated upon ligand binding which opens the acetylcholine channels and permits Ca2+ and Na+ ion influx depending on the subunit composition and stoichiometry of the subunits. The ratio of Ca2+ to Na+ ion influx varies making the receptors either highly Na+ permeable or Ca2+ permeable.
Grottick, AJ, Wyler, R, Trube, G, Higgins, GA, Malherbe, P, Huwyler, J, Corrigall, WA
Lax, P, Eusebi, F, Fucile, S, Renzi, M
ligand-gated ion channel activity of 0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex [plasma membrane]
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