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PTGIS [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-62410
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Prostacyclin synthase , Prostaglandin I2 synthase, Cytochrome P450 8A1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Eicosanoids (Homo sapiens)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)
PTGIS,CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
PTGIS [endoplasmic reticulum membrane] (Homo sapiens)
Endogenous sterols (Homo sapiens)
Sterols are 12-hydroxylated by CYP8B1 (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)
Cytochrome P450 (CYP8B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
PTGIS [endoplasmic reticulum membrane] (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)
Cytochrome P450 (CYP8B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
PTGIS [endoplasmic reticulum membrane] (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
Cytochrome P450 (CYP8B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
PTGIS [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)
PTGIS,CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
PTGIS [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)
Cytochrome P450 (CYP8B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
PTGIS [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)
Cytochrome P450 (CYP8B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
PTGIS [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
Cytochrome P450 (CYP8B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
PTGIS [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Nicotinate metabolism (Homo sapiens)
Nicotinamide salvaging (Homo sapiens)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)
PTGIS,CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
PTGIS [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16647 PTGIS
Gene Names
PTGIS, CYP8, CYP8A1
Chain
chain:1-500
Reference Genes
BioGPS Gene:5740 PTGIS
COSMIC (genes):PTGIS PTGIS
CTD Gene:5740 PTGIS
dbSNP Gene:5740 PTGIS
ENSEMBL:ENSG00000124212 PTGIS
ENSEMBL_homo_sapiens_GENE:ENSG00000124212.6 PTGIS
HGNC:9603 PTGIS
KEGG Gene (Homo sapiens):5740 PTGIS
Monarch:5740 PTGIS
NCBI Gene:5740 PTGIS
OMIM:601699 PTGIS
UCSC:Q16647 PTGIS
Reference Transcript
RefSeq:NM_000961.3 PTGIS
Other Identifiers
11724441_x_at
11724442_a_at
16920156
208131_PM_s_at
208131_s_at
210702_PM_s_at
210702_s_at
211892_PM_s_at
211892_s_at
36533_at
3908931
3908932
3908933
3908935
3908936
3908937
3908938
3908939
3908940
3908943
3908945
3908946
3908949
3908951
3908952
3908953
3908954
3908957
5740
759_at
8066925
A_24_P48723
D38145_at
GE60485
GO:0001516
GO:0003824
GO:0004497
GO:0005506
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005783
GO:0005789
GO:0005886
GO:0005901
GO:0006351
GO:0006355
GO:0006629
GO:0006631
GO:0006633
GO:0006690
GO:0006693
GO:0006954
GO:0008116
GO:0012501
GO:0016020
GO:0016491
GO:0016705
GO:0016829
GO:0016853
GO:0019371
GO:0020037
GO:0023052
GO:0032088
GO:0034356
GO:0035360
GO:0043226
GO:0045019
GO:0045766
GO:0046872
GO:0048856
GO:0050728
GO:0055086
GO:0071347
GO:0071354
GO:0071456
GO:0097190
GO:0106256
GO:1900119
HMNXSV003054202
ILMN_1667692
PH_hs_0015604
TC20000927.hg
g11139662_3p_s_at
g13699858_3p_s_at
g537948_3p_s_at
Participates
as a candidate of
Cytochrome P450 (CYP8B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
as a member of
PTGIS,CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
PTGIS [endoplasmic reticulum membrane]
(Bos taurus)
PTGIS [endoplasmic reticulum membrane]
(Canis familiaris)
PTGIS [endoplasmic reticulum membrane]
(Danio rerio)
PTGIS [endoplasmic reticulum membrane]
(Mus musculus)
PTGIS [endoplasmic reticulum membrane]
(Rattus norvegicus)
PTGIS [endoplasmic reticulum membrane]
(Sus scrofa)
PTGIS [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000952.1
Guide to Pharmacology - Targets
1356
OpenTargets
ENSG00000124212
ZINC - Substances
PTGIS_HUMAN
ZINC target
Q16647
PRO
Q16647
PDB
3B6H
,
2IAG
GeneCards
Q16647
HPA
ENSG00000124212-PTGIS
Ensembl
ENSP00000244043
,
ENST00000244043
,
ENSG00000124212
Pharos - Targets
Q16647
Orphanet
25288
ZINC - Predictions - Purchasable
PTGIS_HUMAN
HMDB Protein
HMDBP01129
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