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ATIC [cytosol]
Stable Identifier
R-HSA-62506
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, Bifunctional purine biosynthesis protein PURH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC)), Bifunctional purine biosynthesis protein PURH, Phosphoribosylaminoimidazolecarboxamide formyltransferase , AICAR transformylase, IMP cyclohydrolase , Inosinicase, IMP synthetase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleotide biosynthesis (Homo sapiens)
Purine ribonucleoside monophosphate biosynthesis (Homo sapiens)
AICAR + 10-Formyl-THF => FAICAR + THF (Homo sapiens)
ATIC dimer [cytosol] (Homo sapiens)
ATIC [cytosol] (Homo sapiens)
FAICAR => IMP + H2O (Homo sapiens)
ATIC dimer [cytosol] (Homo sapiens)
ATIC [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31939 ATIC
Gene Names
ATIC, PURH, OK/SW-cl.86
Chain
chain:1-592, initiator methionine:, chain:2-592
Reference Genes
BioGPS Gene:471 ATIC
COSMIC (genes):ATIC ATIC
CTD Gene:471 ATIC
dbSNP Gene:471 ATIC
ENSEMBL:ENSG00000138363 ATIC
ENSEMBL_homo_sapiens_GENE:ENSG00000138363.15 ATIC
HGNC:794 ATIC
KEGG Gene (Homo sapiens):471 ATIC
Monarch:471 ATIC
NCBI Gene:471 ATIC
OMIM:601731 ATIC
UCSC:P31939 ATIC
Reference Transcript
RefSeq:NM_004044.6 ATIC
Other Identifiers
11715755_a_at
16890490
208758_PM_at
208758_at
2526766
2526767
2526768
2526769
2526770
2526771
2526772
2526776
2526777
2526779
2526780
2526782
2526783
2526784
2526785
2526786
2526787
2526788
2526793
2526795
2526801
2526802
2526803
2526804
38811_at
471
8048120
A_23_P68087
D82348_at
GE57324
GO:0003360
GO:0003824
GO:0003937
GO:0004643
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005886
GO:0006139
GO:0006164
GO:0006177
GO:0006189
GO:0006575
GO:0008152
GO:0010035
GO:0016020
GO:0016740
GO:0016787
GO:0021549
GO:0021987
GO:0031100
GO:0042803
GO:0043226
GO:0044208
GO:0045296
GO:0046452
GO:0046654
GO:0048856
GO:0055086
GO:0070062
GO:0097294
GO:0098761
GO:1901135
HMNXSV003041780
ILMN_1673991
PH_hs_0005040
TC02001260.hg
TC02003807.hg
g2317691_3p_at
Participates
as a component of
ATIC dimer [cytosol] (Homo sapiens)
Other forms of this molecule
ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol]
ATIC(1-229)-p-7Y-ALK(1058-1620) fusion [cytosol]
ATIC(1-230)-ALK(1059-1620) fusion [cytosol]
ATIC(1-229)-ALK(1058-1620) fusion [cytosol]
Inferred To
PURH [cytosol]
(Gallus gallus)
BEST:GH11240 [cytosol]
(Drosophila melanogaster)
atic [cytosol]
(Danio rerio)
atic-1 [cytosol]
(Caenorhabditis elegans)
ATIC [cytosol]
(Bos taurus)
ATIC [cytosol]
(Canis familiaris)
ATIC [cytosol]
(Dictyostelium discoideum)
ATIC [cytosol]
(Mus musculus)
ATIC [cytosol]
(Rattus norvegicus)
ATIC [cytosol]
(Saccharomyces cerevisiae)
ATIC [cytosol]
(Schizosaccharomyces pombe)
ATIC [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_004035.2
OpenTargets
ENSG00000138363
ZINC - Substances
PUR9_HUMAN
ZINC - Biogenic
PUR9_HUMAN
ZINC target
P31939
PRO
P31939
PDB
1PL0
,
1PKX
,
1P4R
,
5UZ0
,
5UY8
ZINC - Metabolites
PUR9_HUMAN
IntEnz
3.5.4.10
,
2.1.2.3
GeneCards
P31939
HPA
ENSG00000138363-ATIC
Ensembl
ENSP00000415935
,
ENSG00000138363
,
ENST00000435675
,
ENSP00000236959
,
ENST00000236959
Pharos - Targets
P31939
ZINC - Predictions - Purchasable
PUR9_HUMAN
Orphanet
19848
HMDB Protein
HMDBP00882
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
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