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RAD51 [nucleoplasm]
Stable Identifier
R-HSA-62637
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA repair protein RAD51 homolog 1 (hRAD51) (HsRAD51), DNA repair protein RAD51 homolog 1, hRAD51, HsRAD51
Icon
Locations in the PathwayBrowser for interactor UniProt:Q6NVH7 SWAP1
Expand all
Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
RAD51 [nucleoplasm] (Homo sapiens)
Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)
RAD51 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Homologous DNA Pairing and Strand Exchange (Homo sapiens)
Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
CHEK1 phosphorylates RAD51 (Homo sapiens)
RAD51 [nucleoplasm] (Homo sapiens)
HDR through Single Strand Annealing (SSA) (Homo sapiens)
Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
RAD51 [nucleoplasm] (Homo sapiens)
ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
RAD51 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
RAD51 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
RAD51 [nucleoplasm] (Homo sapiens)
Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)
RAD51 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q06609 RAD51
Gene Names
RAD51, RAD51A, RECA
Chain
initiator methionine:, chain:2-339
Reference Genes
BioGPS Gene:5888 RAD51
COSMIC (genes):RAD51 RAD51
CTD Gene:5888 RAD51
dbSNP Gene:5888 RAD51
ENSEMBL:ENSG00000051180 RAD51
ENSEMBL_homo_sapiens_GENE:ENSG00000051180.17 RAD51
HGNC:9817 RAD51
KEGG Gene (Homo sapiens):5888 RAD51
Monarch:5888 RAD51
NCBI Gene:5888 RAD51
OMIM:179617 RAD51
UCSC:Q06609 RAD51
Reference Transcript
RefSeq:NM_002875.4 RAD51
RefSeq:XM_011521858.2 RAD51
RefSeq:NM_133487.3 RAD51
RefSeq:XM_011521859.2 RAD51
RefSeq:XM_011521860.2 RAD51
RefSeq:XM_006720626.3 RAD51
RefSeq:XM_011521861.2 RAD51
RefSeq:XM_011521857.2 RAD51
RefSeq:NM_001164269.1 RAD51
RefSeq:NM_001164270.1 RAD51
Other Identifiers
11734841_a_at
16799637
1872_at
205023_PM_at
205023_at
205024_PM_s_at
205024_s_at
3590087
3590089
3590090
3590091
3590092
3590093
3590094
3590095
3590096
3590097
3590098
3590099
3590100
5888
7982792
A_23_P88731
D14134_at
GE57077
GO:0000150
GO:0000152
GO:0000166
GO:0000228
GO:0000278
GO:0000722
GO:0000724
GO:0000730
GO:0000781
GO:0000785
GO:0000793
GO:0000794
GO:0000800
GO:0001673
GO:0001932
GO:0003677
GO:0003682
GO:0003690
GO:0003697
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006259
GO:0006260
GO:0006268
GO:0006281
GO:0006310
GO:0006312
GO:0006974
GO:0007131
GO:0008094
GO:0010569
GO:0010833
GO:0016605
GO:0016787
GO:0016887
GO:0017116
GO:0019899
GO:0022414
GO:0023052
GO:0031297
GO:0032200
GO:0032991
GO:0035861
GO:0036211
GO:0036297
GO:0042148
GO:0042802
GO:0043226
GO:0048471
GO:0051106
GO:0051321
GO:0065003
GO:0070182
GO:0070192
GO:0071312
GO:0071479
GO:0072711
GO:0072757
GO:0099182
GO:0140013
GO:0140097
GO:0140299
GO:0140657
GO:0140664
GO:1990414
GO:1990426
GO:1990918
GO:2000001
HMNXSV003027624
ILMN_1795609
ILMN_2257432
ILMN_2363027
PH_hs_0026109
TC15000292.hg
TC15002160.hg
g4506388_3p_a_at
Participates
as a member of
DMC1, RAD51 [nucleoplasm] (Homo sapiens)
as an input of
Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)
Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
CHEK1 phosphorylates RAD51 (Homo sapiens)
as a component of
Meiotic single-stranded DNA complex [nucleoplasm] (Homo sapiens)
Meiotic D-loop complex [nucleoplasm] (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
as an output of
Formation of meiotic holliday junction (Homo sapiens)
RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
Other forms of this molecule
p-T309-RAD51 [nucleoplasm]
Inferred To
RAD51 [nucleoplasm]
(Bos taurus)
RAD51 [nucleoplasm]
(Canis familiaris)
RAD51 [nucleoplasm]
(Dictyostelium discoideum)
RAD51 [nucleoplasm]
(Drosophila melanogaster)
RAD51 [nucleoplasm]
(Gallus gallus)
RAD51 [nucleoplasm]
(Plasmodium falciparum)
RAD51 [nucleoplasm]
(Rattus norvegicus)
RAD51 [nucleoplasm]
(Saccharomyces cerevisiae)
RAD51 [nucleoplasm]
(Schizosaccharomyces pombe)
RAD51 [nucleoplasm]
(Sus scrofa)
rad-51 [nucleoplasm]
(Caenorhabditis elegans)
Rad51 [nucleoplasm]
(Mus musculus)
rad51 [nucleoplasm]
(Danio rerio)
rad51 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002866.2
,
XP_011520161.1
,
XP_011520159.1
,
NP_001157742.1
,
NP_597994.3
,
XP_006720689.1
,
NP_001157741.1
,
XP_011520162.1
,
XP_011520160.1
,
XP_011520163.1
OpenTargets
ENSG00000051180
GeneCards
Q06609
HPA
ENSG00000051180-RAD51
ZINC - Substances
RAD51_HUMAN
ZINC target
Q06609
Ensembl
ENST00000557850
,
ENSP00000267868
,
ENSG00000051180
,
ENSP00000433924
,
ENSP00000493712
,
ENSP00000406602
,
ENST00000532743
,
ENST00000382643
,
ENST00000423169
,
ENST00000645673
,
ENSP00000454176
,
ENST00000267868
,
ENSP00000372088
PRO
Q06609
Pharos - Targets
Q06609
Orphanet
15183
ZINC - Predictions - Purchasable
RAD51_HUMAN
PDB
5NP7
,
8XBW
,
5H1C
,
5H1B
,
8XBX
,
7C9A
,
8BQ2
,
5JZC
,
8JNF
,
8XBU
,
1B22
,
8JNE
,
8XBV
,
8JND
,
5NWL
,
8XBT
,
1N0W
,
8BR2
,
8PBC
,
8PBD
,
7EJC
,
8BSC
,
8GYK
,
8XBY
,
7EJE
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51587 BRCA2
20
BRCA2 D2983Ffs*34 [cytosol]
(R-HSA-9709538)
BRCA2 K2555* [cytosol]
(R-HSA-9711337)
BRCA2 N2553Tfs*95 [cytosol]
(R-HSA-9712872)
BRCA2 T2685Hfs*9 [cytosol]
(R-HSA-9712879)
BRCA2 K2674Rfs*2 [cytosol]
(R-HSA-9712610)
BRCA2 S3231* [cytosol]
(R-HSA-9711458)
BRCA2 I2675Dfs*6 [cytosol]
(R-HSA-9712869)
BRCA2 R2625* [cytosol]
(R-HSA-9711482)
BRCA2 E3071* [cytosol]
(R-HSA-9711354)
BRCA2 V2716Wfs*17 [cytosol]
(R-HSA-9712761)
BRCA2 W2586* [cytosol]
(R-HSA-9711487)
BRCA2 P2767Lfs*10 [cytosol]
(R-HSA-9712509)
BRCA2 K3032* [cytosol]
(R-HSA-9711485)
BRCA2 S2835* [cytosol]
(R-HSA-9711345)
BRCA2 Y3006* [cytosol]
(R-HSA-9711222)
BRCA2 L2926* [cytosol]
(R-HSA-9711348)
BRCA2 R3128* [cytosol]
(R-HSA-9711177)
BRCA2 E2599* [cytosol]
(R-HSA-9711304)
BRCA2 E2571* [cytosol]
(R-HSA-9711560)
BRCA2 Y2977* [cytosol]
(R-HSA-9711182)
0.982
46
UniProt:Q06609 RAD51
2
RAD51 [nucleoplasm]
(R-HSA-62637)
p-T309-RAD51 [nucleoplasm]
(R-HSA-5685231)
0.916
11
UniProt:Q86YC2 PALB2
20
PALB2 Y28C [nucleoplasm]
(R-HSA-9724169)
PALB2 L35P [nucleoplasm]
(R-HSA-9724168)
PALB2 L24S [nucleoplasm]
(R-HSA-9724172)
PALB2 L21A [nucleoplasm]
(R-HSA-9704339)
PALB2 R37H [nucleoplasm]
(R-HSA-9724178)
PALB2 L21F [nucleoplasm]
(R-HSA-9704347)
PALB2 E12* [nucleoplasm]
(R-HSA-9704349)
PALB2 R37C [nucleoplasm]
(R-HSA-9724188)
PALB2 L35F [nucleoplasm]
(R-HSA-9704338)
PALB2 L947F [nucleoplasm]
(R-HSA-9724554)
PALB2 G1043D [nucleoplasm]
(R-HSA-9724584)
PALB2 T1030I [nucleoplasm]
(R-HSA-9704424)
PALB2 T841Qfs*10 [nucleoplasm]
(R-HSA-9704749)
PALB2 L1119P [nucleoplasm]
(R-HSA-9724589)
PALB2 L947S [nucleoplasm]
(R-HSA-9724557)
PALB2 L1143P [nucleoplasm]
(R-HSA-9704428)
PALB2 L1070P [nucleoplasm]
(R-HSA-9724556)
PALB2 C77Vfs*100 [nucleoplasm]
(R-HSA-9704738)
PALB2 L939W [nucleoplasm]
(R-HSA-9704417)
PALB2 L961P [nucleoplasm]
(R-HSA-9724583)
0.845
9
UniProt:Q96B01-2 RAD51AP1
0.791
6
UniProt:Q96B01-3 RAD51AP1
0.75
6
UniProt:O43542 XRCC3
1
XRCC3 [nucleoplasm]
(R-HSA-5685303)
0.729
5
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.718
6
UniProt:O43502 RAD51C
1
RAD51C [nucleoplasm]
(R-HSA-217039)
0.662
6
UniProt:Q14159 SPIDR
1
SPIDR [nucleoplasm]
(R-HSA-5686408)
0.659
6
UniProt:P43351 RAD52
3
monoSUMO1-K411,K412,K414-RAD52 [nucleoplasm]
(R-HSA-4568909)
RAD52 [nucleoplasm]
(R-HSA-62639)
p-Y104-RAD52 [nucleoplasm]
(R-HSA-5686588)
0.635
3
ChEBI:15422 ATP
0.623
11
UniProt:O75417-1 POLQ
0.602
3
UniProt:P28347 TEAD1
1
TEAD1 [nucleoplasm]
(R-HSA-2032774)
0.564
2
UniProt:P36601
2
RAD51 [nucleoplasm]
(R-SPO-62637)
phospho-p-T309-RAD51 [nucleoplasm]
(R-SPO-5685231)
0.553
2
IntAct:EBI-2307559 DT40
0.544
3
IntAct:EBI-2307713 PHIX174
0.544
3
UniProt:Q96KN1 LRAT2
0.543
4
UniProt:P11245 NAT2
2
AcC-NAT2 [cytosol]
(R-HSA-158833)
NAT2 [cytosol]
(R-HSA-158692)
0.543
4
UniProt:Q9BZ95 NSD3
1
WHSC1L1 [nucleoplasm]
(R-HSA-1183230)
0.543
4
UniProt:Q86XE0 SNX32
0.527
2
UniProt:Q14565 DMC1
1
DMC1 [nucleoplasm]
(R-HSA-912490)
0.527
2
UniProt:Q6NVH7 SWAP1
0.524
2
UniProt:O14757 CHEK1
3
CHEK1 [cytosol]
(R-HSA-205285)
CHEK1 [nucleoplasm]
(R-HSA-113826)
p-S317,S345-CHEK1 [nucleoplasm]
(R-HSA-113838)
0.524
3
UniProt:Q14676 MDC1
6
monoSUMO1-K1840-MDC1 [nucleoplasm]
(R-HSA-4570546)
polySUMO2,3-K1840-MDC1 [nucleoplasm]
(R-HSA-4570473)
K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684074)
SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684061)
p-5T-MDC1 [nucleoplasm]
(R-HSA-75236)
MDC1 [nucleoplasm]
(R-HSA-75231)
0.524
3
UniProt:Q13007 IL24
1
IL24 [extracellular region]
(R-HSA-448438)
0.508
2
UniProt:Q00341 HDLBP
1
HDLBP [plasma membrane]
(R-HSA-8858026)
0.499
2
UniProt:Q86YA3 ZGRF1
0.471
2
UniProt:Q9BQ15 NABP2
1
NABP2 [nucleoplasm]
(R-HSA-6814916)
0.463
2
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