Reactome | RAD52 [nucleoplasm]

RAD52 [nucleoplasm]

Stable Identifier

R-HSA-62639

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA repair protein RAD52 homolog

Locations in the PathwayBrowser for interactor UniProt:Q9NPI6 DCP1A

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        SUMOylation of RAD52 with SUMO1 (Homo sapiens)
        
        RAD52 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P43351 RAD52

Gene Names

RAD52

Chain

chain:1-418

Reference Genes

BioGPS Gene:5893 RAD52

COSMIC (genes):RAD52 RAD52

CTD Gene:5893 RAD52

dbSNP Gene:5893 RAD52

ENSEMBL:ENSG00000002016 RAD52

HGNC:9824 RAD52

KEGG:hsa:5893 RAD52

Monarch:5893 RAD52

NCBI Gene:5893 RAD52

OMIM:600392 RAD52

UCSC:P43351 RAD52

Reference Transcript

Other Identifiers

1043_s_at

11731758_at

11731759_s_at

11731760_a_at

11731761_x_at

11746884_a_at

11746885_s_at

11746886_x_at

11748832_a_at

11749968_a_at

11752970_a_at

11753544_a_at

11753545_x_at

1899_s_at

205647_PM_at

205647_at

210630_PM_s_at

210630_s_at

211904_PM_x_at

211904_x_at

3439834

3439835

3439837

3439838

3439839

3439840

3439841

3439842

3439843

3439844

3439847

3439848

3439849

3439850

3439851

3439852

3439853

3439854

3439857

3439858

3439859

3439860

3439861

3439862

3439863

3439864

3439865

3439866

3439867

3439868

3439869

3439872

3439873

3439879

40744_at

5893

7960261

A_23_P64990

A_33_P3242703

GE58929

GO:0000724

GO:0000730

GO:0003677

GO:0003697

GO:0005515

GO:0005634

GO:0005654

GO:0006281

GO:0006302

GO:0006310

GO:0006312

GO:0010792

GO:0032991

GO:0032993

GO:0034599

GO:0042802

GO:0043226

GO:0045002

GO:0065003

GO:2000819

HMNXSV003010972

HMNXSV003021651

HMNXSV003039293

Hs.148221.0.A1_3p_at

ILMN_1731051

ILMN_1781345

L33262_s_at

PH_hs_0022642

TC12001087.hg

U27516_s_at

g4506394_3p_at

g4581007_3p_a_at

g4581009_3p_a_at

Participates

as an input of

as a component of

RAD52 heptamer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-Y104-RAD52 [nucleoplasm]

monoSUMO1-K411,K412,K414-RAD52 [nucleoplasm]

Inferred To

rad52 [nucleoplasm] (Xenopus tropicalis)

RAD52 [nucleoplasm] (Bos taurus)

RAD52 [nucleoplasm] (Canis familiaris)

RAD52 [nucleoplasm] (Dictyostelium discoideum)

RAD52 [nucleoplasm] (Gallus gallus)

RAD52 [nucleoplasm] (Saccharomyces cerevisiae)

RAD52 [nucleoplasm] (Sus scrofa)

rti1 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of RAD52 [nucleoplasm] (Xenopus tropicalis)

Rad52 [nucleoplasm] (Mus musculus)

Rad52 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_602296.2, XP_016875258.1, NP_001284349.1, NP_001284348.1, XP_011519292.1, XP_005253777.1, XP_011519293.1, XP_005253778.1

OpenTargets

ENSG00000002016

ENSEMBL

ENSP00000387901, ENSP00000351284, ENSP00000438965, ENSP00000443254, ENST00000468231, ENST00000541619, ENSP00000440268, ENST00000461568, ENST00000544742, ENSP00000434703, ENST00000430095, ENSP00000436008, ENST00000545564, ENST00000358495

HPA

ENSG00000002016-RAD52

PRO

P43351

Pharos - Targets

P43351

PDB

8RIL, 8H1P, 1H2I, 8BJM, 5JRB, 8RJ3, 5XRZ, 1KN0, 5XS0, 8RJW

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43351 RAD52	3	p-Y104-RAD52 [nucleoplasm] (R-HSA-5686588) RAD52 [nucleoplasm] (R-HSA-62639) monoSUMO1-K411,K412,K414-RAD52 [nucleoplasm] (R-HSA-4568909)	0.82	7
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.675	9
UniProt:Q06609 RAD51	2	RAD51 [nucleoplasm] (R-HSA-62637) p-T309-RAD51 [nucleoplasm] (R-HSA-5685231)	0.635	3
UniProt:P35244 RPA3	1	RPA3 [nucleoplasm] (R-HSA-68459)	0.623	3
UniProt:Q9H4B4 PLK3	1	PLK3 [nucleoplasm] (R-HSA-3222161)	0.556	3
UniProt:Q8NG50 RDM1			0.556	5
UniProt:P50221 MEOX1			0.556	3
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.556	3
UniProt:O15131 KPNA5	2	KPNA5 [nucleoplasm] (R-HSA-1176068) KPNA5 [cytosol] (R-HSA-1176062)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q13952-2 NFYC			0.556	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.556	5