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IFNGR2 [plasma membrane]
Stable Identifier
R-HSA-629620
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interferon gamma receptor 2, INGR2_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2:JAK1,2 inhibitors [plasma membrane] (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Binding of STAT1 to p-IFNGR1 (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
STAT1 bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNG dimer binds IFNGR (Homo sapiens)
IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNG signaling activates MAPKs (Homo sapiens)
Activated JAK1 binds RAF1 (Homo sapiens)
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR complex with p-JAK [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
JAK1-activated RAF1 phosphorylates MAPKs (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
JAK1-mediated phosphorylation of RAF1 (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2:JAK1,2 inhibitors [plasma membrane] (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
JAK2-activated MAPKs phosphorylate YBX1 (Homo sapiens)
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR complex with p-JAK [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
Phosphorylation of IFNGR1 by JAK kinases (Homo sapiens)
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR complex with p-JAK [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
Phosphorylation of JAK2 (Homo sapiens)
IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
Phosphorylation of STAT1 at Ser727 (Homo sapiens)
p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
Phosphorylation of STAT1 by JAK kinases (Homo sapiens)
STAT1 bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
Regulation of IFNG signaling (Homo sapiens)
Dephosphorylation of JAKs by PTPs (Homo sapiens)
IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR complex with p-JAK [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
SOCS-1 and SOCS-3 binds to p-JAK2 (Homo sapiens)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Homo sapiens)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
Release of STAT1 dimer from active receptor unit (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
Transphosphorylation of JAK1 (Homo sapiens)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Homo sapiens)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR complex with p-JAK [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
IFNGR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P38484 IFNGR2
Gene Names
IFNGR2, IFNGT1
Chain
signal peptide:1-21, chain:22-337
Reference Genes
BioGPS Gene:3460 IFNGR2
COSMIC (genes):IFNGR2 IFNGR2
CTD Gene:3460 IFNGR2
dbSNP Gene:3460 IFNGR2
ENSEMBL:ENSG00000159128 IFNGR2
HGNC:5440 IFNGR2
KEGG:hsa:3460 IFNGR2
Monarch:3460 IFNGR2
NCBI Gene:3460 IFNGR2
OMIM:147569 IFNGR2
UCSC:P38484 IFNGR2
Reference Transcript
RefSeq:NM_005534.3 IFNGR2
Other Identifiers
11715532_a_at
16922275
201642_PM_at
201642_at
3460
3918638
3918639
3918640
3918641
3918642
3918645
3918647
3918648
3918650
3918651
3918652
3918653
3918654
3918660
3918661
3918666
3918667
3918668
3918669
3918670
3918671
41140_at
75317_s_at
8068280
A_14_P120732
A_23_P29036
GE61247
GO:0000139
GO:0001774
GO:0002376
GO:0004896
GO:0004906
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0007166
GO:0009615
GO:0016020
GO:0019221
GO:0030659
GO:0031410
GO:0038196
GO:0043226
GO:0051607
GO:0060089
GO:0060333
GO:0098542
GO:0098586
HMNXSV003052949
ILMN_1764964
PH_hs_0024785
TC21000129.hg
U05875_at
g5031782_3p_at
Participates
as a component of
IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
Inferred To
Ifngr2 [plasma membrane]
(Mus musculus)
Ifngr2 [plasma membrane]
(Rattus norvegicus)
ifnlr1 [plasma membrane]
(Danio rerio)
ifngr2 [plasma membrane]
(Danio rerio)
ifngr2 [plasma membrane]
(Xenopus tropicalis)
Homologues of IFNGR2 [plasma membrane]
(Danio rerio)
Homologues of IFNGR2 [plasma membrane]
(Xenopus tropicalis)
IFNGR2 [plasma membrane]
(Bos taurus)
IFNGR2 [plasma membrane]
(Canis familiaris)
IFNGR2 [plasma membrane]
(Gallus gallus)
IFNGR2 [plasma membrane]
(Sus scrofa)
crfb12 [plasma membrane]
(Danio rerio)
ifngr2.2 [plasma membrane]
(Xenopus tropicalis)
il10rb [plasma membrane]
(Xenopus tropicalis)
crfb4 [plasma membrane]
(Danio rerio)
il22ra2 [plasma membrane]
(Danio rerio)
il10ra [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_005525.2
Guide to Pharmacology - Targets
1726
ENSEMBL
ENST00000576463
,
ENST00000290219
,
ENSP00000458487
,
ENSG00000262795
,
ENSP00000290219
,
ENSG00000159128
OpenTargets
ENSG00000159128
GeneCards
IFNGR2
HPA
ENSG00000159128-IFNGR2
PRO
P38484
Pharos - Targets
P38484
GlyGen
P38484
Orphanet
IFNGR2
PDB
5EH1
,
6E3L
,
6E3K
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75396 SEC22B
6
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688566)
SEC22B [phagocytic vesicle membrane]
(R-HSA-8863938)
SEC22B [endoplasmic reticulum membrane]
(R-HSA-5688150)
SEC22B [ER to Golgi transport vesicle membrane]
(R-HSA-5688565)
SEC22B [transport vesicle]
(R-HSA-6810994)
SEC22B [Golgi membrane]
(R-HSA-6810993)
0.556
3
UniProt:Q15848 ADIPOQ
1
ADIPOQ [extracellular region]
(R-HSA-1183052)
0.556
3
UniProt:Q01453 PMP22
1
PMP22 [plasma membrane]
(R-HSA-9615623)
0.556
3
UniProt:Q5QGT7 RTP2
2
RTP2 [endoplasmic reticulum membrane]
(R-HSA-9752982)
RTP2 [plasma membrane]
(R-HSA-8939446)
0.556
3
UniProt:P11686 SFTPC
9
pro-SFTPC P115L [endoplasmic reticulum membrane]
(R-HSA-5688352)
pro-SFTPC P30L [endoplasmic reticulum membrane]
(R-HSA-5688365)
pro-SFTPC [endoplasmic reticulum membrane]
(R-HSA-5683842)
pro-SFTPC [multivesicular body lumen]
(R-HSA-5685298)
SFTPC [extracellular region]
(R-HSA-5683685)
SFTPC [clathrin-coated endocytic vesicle]
(R-HSA-5686342)
SFTPC [lamellar body]
(R-HSA-5683717)
SFTPC(24-58) [multivesicular body lumen]
(R-HSA-5685899)
SFTPC(59-197) [multivesicular body lumen]
(R-HSA-5685871)
0.556
3
UniProt:P13861 PRKAR2A
2
PRKAR2A [cytosol]
(R-HSA-57840)
PRKAR2A [ciliary base]
(R-HSA-5610412)
0.463
2
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