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POLR1C [nucleoplasm]
Stable Identifier
R-HSA-63498
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HsRPAC1, DNA-directed RNA polymerases I and III subunit RPAC1, DNA-directed RNA polymerase I and III 40 kDa polypeptide , RPA40, RPA39
Locations in the PathwayBrowser for interactor UniProt:Q5RL73 RBM48
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)
POLR1C [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15160 POLR1C
Gene Names
POLR1C, POLR1E
Chain
initiator methionine:, chain:2-346
Reference Genes
BioGPS Gene:9533 POLR1C
COSMIC (genes):POLR1C POLR1C
CTD Gene:9533 POLR1C
dbSNP Gene:9533 POLR1C
ENSEMBL:ENSG00000171453 POLR1C
ENSEMBL_homo_sapiens_GENE:ENSG00000171453.20 POLR1C
HGNC:20194 POLR1C
KEGG Gene (Homo sapiens):9533 POLR1C
Monarch:9533 POLR1C
NCBI Gene:9533 POLR1C
OMIM:610060 POLR1C
UCSC:O15160 POLR1C
Reference Transcript
RefSeq:NM_203290.3 POLR1C
RefSeq:NM_001318876.1 POLR1C
Other Identifiers
11719195_a_at
11740797_x_at
17009032
207515_PM_s_at
207515_s_at
209317_PM_at
209317_at
2908053
2908054
2908055
2908056
2908059
2908061
2908062
2908064
2908065
2908067
2908069
2908070
2908072
2908073
2908074
2908076
2908099
36460_at
8119842
9533
A_14_P119687
A_33_P3339103
GO:0000428
GO:0001054
GO:0001056
GO:0001650
GO:0003677
GO:0003824
GO:0003899
GO:0005515
GO:0005634
GO:0005654
GO:0005666
GO:0005730
GO:0005736
GO:0005737
GO:0005829
GO:0006351
GO:0006360
GO:0006383
GO:0016740
GO:0043226
GO:0046983
GO:0140098
HMNXSV003040440
ILMN_1746686
ILMN_1767219
PH_hs_0000558
g2266928_3p_at
g4759045_3p_a_at
Participates
as a component of
RNA Polymerase III Holoenzyme [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
as an input of
Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)
Other forms of this molecule
POLR1C [cytosol]
Inferred To
polr1c [nucleoplasm]
(Dictyostelium discoideum)
Polr1c [nucleoplasm]
(Mus musculus)
POLR1C [nucleoplasm]
(Bos taurus)
POLR1C [nucleoplasm]
(Canis familiaris)
POLR1C [nucleoplasm]
(Gallus gallus)
POLR1C [nucleoplasm]
(Plasmodium falciparum)
POLR1C [nucleoplasm]
(Rattus norvegicus)
POLR1C [nucleoplasm]
(Sus scrofa)
rpac-40 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of POLR1C [nucleoplasm]
(Xenopus tropicalis)
rpc40 [nucleoplasm]
(Schizosaccharomyces pombe)
Polr1C [nucleoplasm]
(Drosophila melanogaster)
RPC40 [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001305805.1
,
NP_976035.1
OpenTargets
ENSG00000171453
HPA
ENSG00000171453-POLR1C
GeneCards
O15160
Ensembl
ENST00000607635
,
ENST00000304004
,
ENSP00000496683
,
ENSP00000496044
,
ENSP00000307212
,
ENSG00000171453
,
ENST00000642195
PRO
O15160
Pharos - Targets
O15160
Orphanet
19587
HMDB Protein
HMDBP11916
PDB
7D59
,
7AEA
,
7VBC
,
8ITY
,
7DU2
,
7DN3
,
7AE1
,
7OBA
,
7A6H
,
7FJI
,
7OBB
,
7AST
,
7AE3
,
7VBA
,
8A43
,
7FJJ
,
7D58
,
7OB9
,
8IUE
,
8IUH
,
7VBB
Interactors (132)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DPB6 RPAC2
0.918
19
UniProt:P15531 NME1
1
NME1 [cytosol]
(R-HSA-60022)
0.87
11
UniProt:Q9UKT9 IKZF3
0.841
9
UniProt:P52435 POLR2J
1
POLR2J [nucleoplasm]
(R-HSA-63531)
0.831
12
UniProt:Q13829 TNFAIP1
1
TNFAIP1 [cytosol]
(R-HSA-9696531)
0.781
9
UniProt:P19388 POLR2E
2
POLR2E [nucleoplasm]
(R-HSA-83713)
POLR2E [cytosol]
(R-HSA-1964438)
0.775
7
UniProt:O95602 POLR1A
1
POLR1A [nucleoplasm]
(R-HSA-63494)
0.725
5
UniProt:Q9UFD9 RIM3A
0.718
6
UniProt:Q9Y3Q8 T22D4
0.718
6
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.718
6
UniProt:Q16637 SMN1
2
SMN1 [nucleoplasm]
(R-HSA-191892)
SMN1 [cytosol]
(R-HSA-191839)
0.718
6
UniProt:Q719H9 KCTD1
1
KCTD1 [nucleoplasm]
(R-HSA-8864339)
0.718
6
UniProt:Q96CA5 BIRC7
1
BIRC7 [cytosol]
(R-HSA-50855)
0.718
6
UniProt:Q8NA61-2 CBY2
0.696
5
UniProt:Q13064 MKRN3
0.696
5
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.696
5
UniProt:Q9GZS1 POLR1E
1
POLR1E [nucleoplasm]
(R-HSA-5419294)
0.669
5
UniProt:Q9NVU0 POLR3E
2
POLR3E [nucleoplasm]
(R-HSA-83706)
POLR3E [cytosol]
(R-HSA-1964451)
0.643
5
UniProt:P61218 POLR2F
2
POLR2F [nucleoplasm]
(R-HSA-83714)
POLR2F [cytosol]
(R-HSA-1964441)
0.643
6
UniProt:Q9HAV7 GRPEL1
1
GRPEL1 [mitochondrial inner membrane]
(R-HSA-1252062)
0.601
4
UniProt:P31943 HNRNPH1
1
HNRNPH1 [nucleoplasm]
(R-HSA-71941)
0.601
4
UniProt:Q9BSW2 CRACR2A
2
CRACR2A [extracellular region]
(R-HSA-6806289)
CRACR2A [specific granule lumen]
(R-HSA-6799553)
0.556
3
UniProt:P19237 TNNI1
1
TNNI1 [cytosol]
(R-HSA-390539)
0.556
3
UniProt:Q5VWN6-2 TASOR2
0.556
3
UniProt:Q8IYA8 IHO1
0.556
3
UniProt:Q9BYR8 KRTAP3-1
1
KRTAP3-1 [cytosol]
(R-HSA-6809868)
0.556
3
UniProt:Q8WZ19 KCTD13
1
KCTD13 [cytosol]
(R-HSA-9696533)
0.556
3
UniProt:Q9H1A7 RPB1C
0.556
3
UniProt:Q9BWF2 TRAIP
1
TRAIP [cytosol]
(R-HSA-8851652)
0.556
3
UniProt:Q9UHP6 RSP14
0.556
3
UniProt:Q9NU63-3 ZFP57
0.556
3
UniProt:Q96LM5 SMIP2
0.556
3
UniProt:O60504 SORBS3
1
SORBS3 [cytosol]
(R-HSA-445805)
0.556
3
UniProt:Q9Y3D9 MRPS23
1
MRPS23 [mitochondrial inner membrane]
(R-HSA-5368249)
0.556
3
UniProt:Q9H4Y5 GSTO2
1
GSTO2 [cytosol]
(R-HSA-176066)
0.556
3
UniProt:Q9Y5P6 GMPPB
1
GMPPB [cytosol]
(R-HSA-532525)
0.556
3
UniProt:P02489 CRYAA
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q9HC52 CBX8
1
CBX8 [nucleoplasm]
(R-HSA-389117)
0.556
3
UniProt:Q08117-2 TLE5
0.556
3
UniProt:Q5RL73 RBM48
0.556
3
UniProt:Q7Z353 HDX
0.556
3
UniProt:P59991 KRTAP12-2
1
KRTAP12-2 [cytosol]
(R-HSA-6810271)
0.556
3
UniProt:P62487 POLR2G
1
POLR2G [nucleoplasm]
(R-HSA-63517)
0.556
3
UniProt:Q5T686 AVPI1
0.556
3
IntAct:EBI-22384931 CCSB ORF ID
0.556
3
UniProt:O95561 CA105
0.556
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.556
3
IntAct:EBI-22432104 CCSB ORF ID
0.556
3
UniProt:Q8WWB5 PIHD2
0.556
3
UniProt:Q53FD0-2 ZC2HC1C
0.556
3
UniProt:P17482 HXB9
0.556
3
UniProt:Q8IYX7 SAXO1
0.556
3
UniProt:Q9NS73-5 MBIP
0.556
3
UniProt:Q01546 KRT76
1
KRT76 [cytosol]
(R-HSA-6809633)
0.556
5
UniProt:O96000 NDUFB10
1
NDUFB10 [mitochondrial inner membrane]
(R-HSA-60194)
0.556
3
UniProt:Q9NZ72 STMN3
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:O95678 KRT75
1
KRT75 [cytosol]
(R-HSA-6809652)
0.556
3
UniProt:Q5T3J3 LRIF1
0.556
3
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:B2RXF5 ZBT42
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q9GZT8 NIF3L
0.556
3
UniProt:Q9Y2P0 ZN835
0.556
3
UniProt:Q8WXE1 ATRIP
1
ATRIP [nucleoplasm]
(R-HSA-176231)
0.556
3
IntAct:EBI-10171584 80125
0.556
3
UniProt:P07954 FH
1
FH [mitochondrial matrix]
(R-HSA-70980)
0.556
3
UniProt:Q8IXW7 Q8IXW7
0.556
3
UniProt:P46934-3 NEDD4
0.556
3
UniProt:Q9Y250 LZTS1
0.556
3
UniProt:Q0VAL7 Q0VAL7
0.556
3
UniProt:Q6PF18 MORN3
0.556
3
UniProt:Q8WUT1 Q8WUT1
0.556
3
UniProt:P0C7X2 ZNF688
1
ZNF688 [nucleoplasm]
(R-HSA-2248884)
0.556
3
UniProt:Q6PI77 GASP3
0.556
3
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.556
3
UniProt:Q9H2G9 BLZF1
1
BLZF1 [Golgi membrane]
(R-HSA-2422372)
0.556
3
UniProt:Q70EL1-9 USP54
0.556
3
UniProt:A8MW99 MEI4
0.556
3
UniProt:Q9BTD3 TM121
0.556
3
UniProt:Q9NZV7 ZIM2
1
ZIM2 [nucleoplasm]
(R-HSA-974996)
0.556
5
UniProt:Q8IVP9 ZNF547
1
ZNF547 [nucleoplasm]
(R-HSA-1973874)
0.556
3
UniProt:Q6PJQ5 FOXR2
0.556
3
UniProt:Q86TJ5 ZNF554
1
ZNF554 [nucleoplasm]
(R-HSA-1973883)
0.556
3
UniProt:P25786 PSMA1
2
PSMA1 [nucleoplasm]
(R-HSA-174333)
PSMA1 [cytosol]
(R-HSA-68724)
0.556
3
IntAct:EBI-16439879 CCSB ORF ID
0.556
3
UniProt:Q9H0A9-2 SPATC1L
0.556
3
UniProt:Q12774 ARHGEF5
1
ARHGEF5 [cytosol]
(R-HSA-8873909)
0.556
5
UniProt:Q9UFW8 CGBP1
0.556
3
UniProt:P35452-2 P354522
0.556
3
UniProt:Q9BVN2 RUSC1
0.556
3
UniProt:O75909-2 CCNK
0.556
3
UniProt:Q9H9P5-5 UNKL
0.556
3
UniProt:Q9NQY0 BIN3
0.556
3
UniProt:Q969Q6 P2R3C
0.556
5
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:Q14142 TRIM14
1
TRIM14 [cytosol]
(R-HSA-5624345)
0.556
3
UniProt:O00746 NME4
1
NME4 [mitochondrial inner membrane]
(R-HSA-60026)
0.556
5
UniProt:O43609 SPRY1
3
p-Y53-SPRY1 [cytosol]
(R-HSA-182933)
SPRY1 [plasma membrane]
(R-HSA-182944)
SPRY1 [cytosol]
(R-HSA-182908)
0.556
3
UniProt:Q5JST6 EFHC2
0.556
3
UniProt:Q9NYA3 GOG6A
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.556
3
UniProt:Q6ZNM6 SMI10
0.556
3
UniProt:A0A0A0MR80 A0A0A0MR80
0.556
3
UniProt:Q8N720 ZNF655
1
ZNF655 [nucleoplasm]
(R-HSA-2127575)
0.556
3
UniProt:P08727 KRT19
1
KRT19 [cytosol]
(R-HSA-6809617)
0.556
3
UniProt:P23025 XPA
1
XPA [nucleoplasm]
(R-HSA-67437)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q9H6T3 RPAP3
0.527
2
UniProt:O75575 CRCP
2
CRCP [nucleoplasm]
(R-HSA-5420844)
CRCP [cytosol]
(R-HSA-5420849)
0.527
3
UniProt:Q9HCN4 GPN1
0.527
2
UniProt:Q9NW08 POLR3B
2
POLR3B [cytosol]
(R-HSA-1964435)
POLR3B [nucleoplasm]
(R-HSA-83702)
0.527
4
UniProt:Q9UHW5 GPN3
0.527
3
UniProt:P52434 POLR2H
2
POLR2H [nucleoplasm]
(R-HSA-63523)
POLR2H [cytosol]
(R-HSA-1964450)
0.527
3
UniProt:P19784 CSNK2A2
2
CSNK2A2 [nucleoplasm]
(R-HSA-6805065)
CSNK2A2 [cytosol]
(R-HSA-201721)
0.527
2
UniProt:Q9Y2Y1 POLR3K
2
POLR3K [nucleoplasm]
(R-HSA-1964461)
POLR3K [cytosol]
(R-HSA-1964455)
0.527
3
UniProt:Q9BUI4 POLR3C
2
POLR3C [cytosol]
(R-HSA-1964448)
POLR3C [nucleoplasm]
(R-HSA-1964430)
0.527
4
UniProt:Q9BT43 POLR3GL
2
POLR3GL [nucleoplasm]
(R-HSA-1964458)
POLR3GL [cytosol]
(R-HSA-1964463)
0.527
4
UniProt:P05423 POLR3D
2
POLR3D [nucleoplasm]
(R-HSA-83704)
POLR3D [cytosol]
(R-HSA-1964429)
0.527
4
UniProt:Q9Y535 POLR3H
2
POLR3H [nucleoplasm]
(R-HSA-83710)
POLR3H [cytosol]
(R-HSA-1964440)
0.527
5
UniProt:O14802 POLR3A
2
POLR3A [cytosol]
(R-HSA-1964433)
POLR3A [nucleoplasm]
(R-HSA-83700)
0.527
4
UniProt:O15318 POLR3G
2
POLR3G [nucleoplasm]
(R-HSA-1964459)
POLR3G [cytosol]
(R-HSA-1964446)
0.527
4
UniProt:Q9H1D9 POLR3F
2
POLR3F [cytosol]
(R-HSA-1964434)
POLR3F [nucleoplasm]
(R-HSA-83708)
0.527
4
UniProt:Q3B726 POLR1F
1
TWISTNB [nucleoplasm]
(R-HSA-5419290)
0.527
2
UniProt:P62875 POLR2L
2
POLR2L [nucleoplasm]
(R-HSA-83715)
POLR2L [cytosol]
(R-HSA-1964467)
0.527
3
UniProt:O15446 POLR1G
1
CD3EAP [nucleoplasm]
(R-HSA-5419289)
0.527
3
UniProt:Q9H9Y6 POLR1B
1
POLR1B [nucleoplasm]
(R-HSA-63496)
0.527
4
UniProt:Q8N448 LNX2
0.488
2
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