Reactome | POLR2A [nucleoplasm]

POLR2A [nucleoplasm]

Stable Identifier

R-HSA-63502

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RNA Pol II (unphosphorylated) largest subunit, DNA-directed RNA polymerase II largest subunit , RPB1

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Chromosome Maintenance (Homo sapiens)
  - Telomere Maintenance (Homo sapiens)
    - Inhibition of DNA recombination at telomere (Homo sapiens)
      - TERRA transcription (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (generic) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by FGFR in disease (Homo sapiens)
    - Signaling by FGFR2 in disease (Homo sapiens)
      - FGFR2 mutant receptor activation (Homo sapiens)
        
        Signaling by FGFR2 IIIa TM (Homo sapiens)
        
        Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Transcription of the HIV genome (Homo sapiens)
        
        Fall Back to Closed Pre-initiation Complex (Homo sapiens)
        
        HIV-1 closed pre-initiation complex [nucleoplasm] (Homo sapiens)
        
        HIV-1 promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex* [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV-1 open pre-initiation complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV Promoter Opening: First Transition (Homo sapiens)
        
        HIV-1 closed pre-initiation complex [nucleoplasm] (Homo sapiens)
        
        HIV-1 promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex* [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV-1 open pre-initiation complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV Transcription Initiation (Homo sapiens)
        
        Abortive HIV-1 initiation after formation of the first phosphodiester bond (Homo sapiens)
        
        HIV-1 transcription complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex (Homo sapiens)
        
        HIV-1 initiation complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV-1 open pre-initiation complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Newly formed phosphodiester bond stabilized and PPi released (Homo sapiens)
        
        HIV-1 initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV-1 transcription complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP (Homo sapiens)
        
        HIV-1 initiation complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV-1 initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Pol II CTD phosphorylation and interaction with CE during HIV infection (Homo sapiens)
        
        Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex (Homo sapiens)
        
        HIV-1 transcription complex containing extruded transcript to +30 [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV-1 transcription complex containing transcript to +30 [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)
        
        HIV-1 transcription complex containing extruded transcript to +30 [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II HIV Promoter Escape (Homo sapiens)
        
        Abortive HIV-1 Initiation After Second Transition (Homo sapiens)
        
        HIV-1 transcription complex containing 4-9 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Abortive HIV-1 Initiation Before Second Transition (Homo sapiens)
        
        HIV-1 Promoter Escape Complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition (Homo sapiens)
        
        HIV-1 transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV-1 transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Addition of nucleotides 5 through 9 on the growing HIV-1 transcript (Homo sapiens)
        
        HIV-1 transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV-1 transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Addition of nucleotides between position +11 and +30 on HIV-1 transcript (Homo sapiens)
        
        HIV-1 transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV-1 transcription complex containing transcript to +30 [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition (Homo sapiens)
        
        HIV-1 transcription complex containing 3 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV-1 transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Addition of the third nucleotide on the nascent HIV-1 transcript (Homo sapiens)
        
        HIV-1 transcription complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        HIV-1 transcription complex containing 3 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Unwinding of DNA for the nascent HIV-1 transcript (Homo sapiens)
        
        HIV-1 transcription complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Unwinding of DNA for the nascent HIV-1 transcript: Second Transition (Homo sapiens)
        
        HIV-1 transcription complex containing 3 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- Gene Silencing by RNA (Homo sapiens)
  - MicroRNA (miRNA) biogenesis (Homo sapiens)
    - Pol II mediated transcription of microRNA genes (Homo sapiens)
      - RNA Polymerase II holoenzyme complex (generic) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
  - PIWI-interacting RNA (piRNA) biogenesis (Homo sapiens)
    - RNA polymerase II polymerizes primary piRNA transcript (Homo sapiens)
      - RNA Polymerase II holoenzyme complex (generic) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
  - Transcriptional regulation by small RNAs (Homo sapiens)
    - AGO1,2:small RNA complexes interact with chromatin (Homo sapiens)
      - AGO1,2:miRNA:chromatin:RNA pol II [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Pol II CTD phosphorylation and interaction with CE (Homo sapiens)
    - Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Homo sapiens)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - Pol II transcription complex containing transcript to +30 [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
    - Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
  - RNA Polymerase II Pre-transcription Events (Homo sapiens)
    - Abortive Initiation After Second Transition (Homo sapiens)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - pol II transcription complex containing 4-9 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
    - Abortive Initiation Before Second Transition (Homo sapiens)
      - Pol II Promoter Escape Complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
    - Abortive initiation after formation of the first phosphodiester bond (Homo sapiens)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - pol II transcription complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
    - Fall Back to Closed Pre-initiation Complex (Homo sapiens)
      - pol II closed pre-initiation complex [nucleoplasm] (Homo sapiens)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - pol II open pre-initiation complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
  - RNA Polymerase II Transcription Initiation And Promoter Clearance (Homo sapiens)
    - RNA Polymerase II Promoter Escape (Homo sapiens)
      - Addition of Nucleotides 5 through 9 on the growing Transcript (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - Addition of nucleotides between position +11 and +30 (Homo sapiens)
        
        Pol II transcription complex containing transcript to +30 [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - Addition of the third nucleotide on the nascent transcript (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        pol II transcription complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - Unwinding DNA for the nascent transcript (Homo sapiens)
        
        pol II transcription complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - Unwinding of DNA for the Nascent Transcript: Second Transition (Homo sapiens)
        
        pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
    - RNA Polymerase II Promoter Opening: First Transition (Homo sapiens)
      - pol II closed pre-initiation complex [nucleoplasm] (Homo sapiens)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - pol II open pre-initiation complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
    - RNA Polymerase II Transcription Initiation (Homo sapiens)
      - NTP Binds Active Site of RNA Polymerase II (Homo sapiens)
        
        Pol II initiation complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        pol II open pre-initiation complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - Newly Formed Phosphodiester Bond Stabilized and PPi Released (Homo sapiens)
        
        Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        pol II transcription complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Homo sapiens)
        
        Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        Pol II initiation complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
  - RNA Polymerase II Transcription Pre-Initiation And Promoter Opening (Homo sapiens)
    - Binding of TFIIE to the growing preinitiation complex (Homo sapiens)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex [nucleoplasm] (Homo sapiens)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
    - Formation of the closed pre-initiation complex (Homo sapiens)
      - pol II closed pre-initiation complex [nucleoplasm] (Homo sapiens)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex [nucleoplasm] (Homo sapiens)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
    - Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Homo sapiens)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Homo sapiens)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)
      - RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - FGFR2 alternative splicing (Homo sapiens)
        
        ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)
        
        FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        FGFR2b-specific alternative splicing produces FGFR2b transcript (Homo sapiens)
        
        FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        FGFR2c-specific alternative splicing produces FGFR2c transcript (Homo sapiens)
        
        FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)
        
        FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
        
        POLR2A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24928 POLR2A

Gene Names

POLR2A, POLR2

Chain

chain:1-1970

Reference Genes

BioGPS Gene:5430 POLR2A

COSMIC (genes):POLR2A POLR2A

CTD Gene:5430 POLR2A

dbSNP Gene:5430 POLR2A

ENSEMBL:ENSG00000181222 POLR2A

HGNC:9187 POLR2A

KEGG:hsa:5430 POLR2A

Monarch:5430 POLR2A

NCBI Gene:5430 POLR2A

OMIM:180660 POLR2A

UCSC:P24928 POLR2A

Reference Transcript

RefSeq:NM_000937.4 POLR2A

Participates

as a component of

Other forms of this molecule

p-S2,S5(CTD)-POLR2A [nucleoplasm]

p-3S-POLR2A [nucleoplasm]

Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]

p-S5(CTD)-POLR2A [nucleoplasm]

p-S5,S7(CTD)-POLR2A [nucleoplasm]

p-S2,S7(CTD)-POLR2A [nucleoplasm]

Inferred To

Ghost homologue of POLR2A [nucleoplasm] (Danio rerio)

Ghost homologue of POLR2A [nucleoplasm] (Gallus gallus)

Ghost homologue of POLR2A [nucleoplasm] (Xenopus tropicalis)

Polr2a [nucleoplasm] (Rattus norvegicus)

POLR2A [nucleoplasm] (Bos taurus)

POLR2A [nucleoplasm] (Caenorhabditis elegans)

POLR2A [nucleoplasm] (Canis familiaris)

POLR2A [nucleoplasm] (Dictyostelium discoideum)

POLR2A [nucleoplasm] (Drosophila melanogaster)

POLR2A [nucleoplasm] (Mus musculus)

POLR2A [nucleoplasm] (Plasmodium falciparum)

POLR2A [nucleoplasm] (Saccharomyces cerevisiae)

POLR2A [nucleoplasm] (Schizosaccharomyces pombe)

POLR2A [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_000928.1

OpenTargets

ENSG00000181222

PRO

P24928

Pharos - Targets

P24928

GlyGen

P24928

HMDB Protein

HMDBP00739

PDB

2GHQ, 6Q5Y, 6XRE, 8R60, 6O9L, 8PNQ, 4JXT, 8R65, 8R3L, 7EGB, 8R3K, 7EGC, 6F5P, 5M3J, 7Z1K, 7YCX, 2LTO, 5IYD, 5IYC, 7Z42, 3D9N, 5M3H, 5IY7, 6G0R, 7LBM, 5IYA, 5IYB, 3D9O, 5IY9, 6DRD, 3D9L, 5IY6, 5IY8, 3D9M, 6XKB, 2GHT, 3D9P, 3D9K, 6IC8, 6IC9

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.836	6
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.793	7
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.708	6
UniProt:P23193 TCEA1	1	TCEA1 [nucleoplasm] (R-HSA-65748)	0.708	5
UniProt:P61218 POLR2F	2	POLR2F [cytosol] (R-HSA-1964441) POLR2F [nucleoplasm] (R-HSA-83714)	0.643	5
UniProt:Q8IXW5 RPAP2	1	RPAP2 [nucleoplasm] (R-HSA-6810227)	0.643	4
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.643	3
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.641	3
UniProt:Q9Y5B0 CTDP1	1	CTDP1 [nucleoplasm] (R-HSA-113416)	0.564	2
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.558	6
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.527	2
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	8
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.527	3
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.527	2
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	2
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.527	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.527	4
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.527	3
UniProt:Q03468 ERCC6	2	Ub-ERCC6 [nucleoplasm] (R-HSA-6781853) ERCC6 [nucleoplasm] (R-HSA-54429)	0.499	2
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.483	2
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.483	2

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