Reactome | SOS1 [cytosol]

SOS1 [cytosol]

Stable Identifier

R-HSA-64847

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Son of sevenless protein homolog 1, SOS-1

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Locations in the PathwayBrowser for interactor UniProt:Q9UKS6 PACSIN3

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External Reference Information

External Reference

UniProt:Q07889 SOS1

Gene Names

SOS1

Chain

chain:1-1333

Reference Genes

BioGPS Gene:6654 Q078891

COSMIC (genes):SOS1 SOS1

CTD Gene:6654 Q078891

dbSNP Gene:6654 SOS1

ENSEMBL:ENSG00000115904 SOS1

HGNC:11187 Q078891

KEGG:hsa:6654 Q078891

Monarch:6654 Q078891

NCBI Gene:6654 Q078891

OMIM:182530 Q078891

UCSC:Q07889 Q078891

Reference Transcript

RefSeq:NM_005633.3 Q078891

Participates

as a component of

as an input of

as a member of

as a candidate of

Other forms of this molecule

SOS1 [plasma membrane]

p-4S-SOS1 [cytosol]

Inferred To

gefA [cytosol] (Dictyostelium discoideum)

sos1 [cytosol] (Danio rerio)

sos1 [cytosol] (Xenopus tropicalis)

gefS [cytosol] (Dictyostelium discoideum)

gefJ [cytosol] (Dictyostelium discoideum)

gefC [cytosol] (Dictyostelium discoideum)

gefH [cytosol] (Dictyostelium discoideum)

gefW [cytosol] (Dictyostelium discoideum)

gefD [cytosol] (Dictyostelium discoideum)

gefM [cytosol] (Dictyostelium discoideum)

gefP [cytosol] (Dictyostelium discoideum)

Sos [cytosol] (Drosophila melanogaster)

gefF [cytosol] (Dictyostelium discoideum)

gefK [cytosol] (Dictyostelium discoideum)

gefR [cytosol] (Dictyostelium discoideum)

gefI [cytosol] (Dictyostelium discoideum)

Sos1 [cytosol] (Mus musculus)

Sos1 [cytosol] (Rattus norvegicus)

gefB [cytosol] (Dictyostelium discoideum)

LTE1 [cytosol] (Saccharomyces cerevisiae)

gefY [cytosol] (Dictyostelium discoideum)

gefBB [cytosol] (Dictyostelium discoideum)

gefE [cytosol] (Dictyostelium discoideum)

SOS1 [cytosol] (Bos taurus)

SOS1 [cytosol] (Canis familiaris)

SOS1 [cytosol] (Gallus gallus)

SOS1 [cytosol] (Sus scrofa)

gefV [cytosol] (Dictyostelium discoideum)

gefAA [cytosol] (Dictyostelium discoideum)

gefO [cytosol] (Dictyostelium discoideum)

gefG [cytosol] (Dictyostelium discoideum)

sos-1 [cytosol] (Caenorhabditis elegans)

Homologues of SOS1 [cytosol] (Dictyostelium discoideum)

gefL [cytosol] (Dictyostelium discoideum)

gefQ [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_005624.2

Guide to Pharmacology - Targets

3096

OpenTargets

ENSG00000115904

ENSEMBL

ENSG00000115904, ENST00000402219, ENSP00000384675

ZINC - Substances

SOS1_HUMAN

ZINC target

Q07889

PRO

Q07889

GlyGen

Q07889

PDB

5OVG, 6BVM, 5WFQ, 6SFR, 6CUR, 7KFZ, 5WFR, 8XJJ, 6F08, 6BVK, 7AVS, 5WFO, 7AVV, 3KSY, 6D5H, 7AVU, 6D5J, 6D55, 6D59, 6D5W, 8BE7, 6V9O, 2II0, 1XDV, 6V9F, 4US0, 6D5E, 6V9N, 1NVU, 1AWE, 4URV, 8BE4, 4URZ, 4URX, 1Q9C, 4URY, 5OVI, 8BE5, 5OVF, 7UKR, 6BVL, 7UKS, 5WFP, 6CUP, 8BE6, 5OVD, 1DBH, 4NYM, 5OVE, 6BVJ, 6D5G, 7AVT, 1XD2, 6V94, 7AVL, 6D5L, 6Y44, 6D56, 6V9J, 6CUO, 8BE9, 8BE8, 7AVI, 8BE2, 6D5M, 4US1, 6V9L, 6V9M, 6D5V, 1NVV, 8BEA, 1NVX, 1NVW, 4URU, 6EPL, 4NYJ, 4NYI, 4URW, 6SCM, 6EPO, 4US2, 1XD4, 6EPP, 5OVH, 1BKD, 6EPM, 6BVI, 6EPN

HPA

ENSG00000115904-SOS1

GeneCards

SOS1

Pharos - Targets

Q07889

Orphanet

SOS1

HMDB Protein

HMDBP08580

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.973	30
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.938	11
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.792	6
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.758	7
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.722	8
UniProt:P08631 HCK	2	HCK [cytosol] (R-HSA-167708) p-HCK [cytosol] (R-HSA-9676060)	0.692	4
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.669	3
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.667	3
UniProt:P20929 NEB	1	NEB [cytosol] (R-HSA-390569)	0.618	3
UniProt:Q5TCZ1-2			0.611	5
UniProt:Q9UNS2 COPS3	2	COPS3 [nucleoplasm] (R-HSA-5697017) COPS3 [cytosol] (R-HSA-416973)	0.581	3
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.564	2
UniProt:P57075-2 UBASH3A			0.556	3
UniProt:O60239 3BP5			0.553	2
UniProt:Q8IZP0 ABI1	2	ABI1 [cytosol] (R-HSA-1671643) p-5S-ABI1 [cytosol] (R-HSA-2029034)	0.544	2
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.536	3
UniProt:Q9UKS6 PACSIN3	1	PACSIN3 [cytosol] (R-HSA-8868270)	0.524	2
UniProt:Q9Y5X1 SNX9	3	SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990) SNX9 [cytosol] (R-HSA-8867737)	0.524	2
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.483	3

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