Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TCEA1 [nucleoplasm]
Stable Identifier
R-HSA-65748
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
TFIIS protein, Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o), Transcription elongation factor A protein 1, Transcription elongation factor S-II protein 1, Transcription elongation factor TFIIS.o
Locations in the PathwayBrowser for interactor UniProt:Q8N7H5 PAF1
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
TCEA1 [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
TCEA1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Transcription of the HIV genome (Homo sapiens)
Formation of HIV elongation complex in the absence of HIV Tat (Homo sapiens)
Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
TCEA1 [nucleoplasm] (Homo sapiens)
HIV Transcription Elongation (Homo sapiens)
Tat-mediated elongation of the HIV-1 transcript (Homo sapiens)
Formation of HIV-1 elongation complex containing HIV-1 Tat (Homo sapiens)
Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
TCEA1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
TCEA1 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
TCEA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23193 TCEA1
Gene Names
TCEA1, GTF2S, TFIIS
Chain
chain:1-301
Reference Genes
BioGPS Gene:6917 TCEA1
COSMIC (genes):TCEA1 TCEA1
CTD Gene:6917 TCEA1
dbSNP Gene:6917 TCEA1
ENSEMBL:ENSG00000187735 TCEA1
HGNC:11612 TCEA1
KEGG:hsa:6917 TCEA1
Monarch:6917 TCEA1
NCBI Gene:6917 TCEA1
OMIM:601425 TCEA1
UCSC:P23193 TCEA1
Reference Transcript
RefSeq:NM_201437.2 TCEA1
RefSeq:NM_006756.3 TCEA1
Other Identifiers
1073_at
11734918_s_at
11734919_s_at
11752908_a_at
17077222
216241_PM_s_at
216241_s_at
2617135
2617136
2617137
2617138
2617139
2617140
2617141
3135531
3135533
3135534
3135541
3135542
3135544
3135547
3135548
3135549
3135550
3135551
3135552
3135553
3135554
3135555
3135556
3135557
3135558
6917
8078600
8150818
A_23_P132444
A_24_P126651
GE58095
GE59984
GO:0003676
GO:0003677
GO:0003746
GO:0005515
GO:0005634
GO:0005654
GO:0005669
GO:0005730
GO:0006351
GO:0006355
GO:0006366
GO:0006368
GO:0006414
GO:0008270
GO:0043226
GO:0045182
GO:0045944
GO:0046872
HMNXSV003006625
Hs.78869.1.S1_3p_a_at
ILMN_1698139
ILMN_1709851
ILMN_2357770
M81601_at
PH_hs_0027158
TC08001216.hg
Participates
as a component of
HIV-1 Tat-containing aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
HIV-1 paused processive elongation complex [nucleoplasm] (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
HIV-1 elongation complex [nucleoplasm] (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
HIV-1 elongation complex containing Tat [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
Tat-containing elongation complex prior to separation [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing paused processive elongation complex [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing arrested processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb(Cyclin T1:Cdk9)-containing elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
HIV-1 aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
as an input of
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
as an output of
Elongating transcript encounters a lesion in the template (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
Inferred To
TCEA1 [nucleoplasm]
(Bos taurus)
TCEA1 [nucleoplasm]
(Caenorhabditis elegans)
TCEA1 [nucleoplasm]
(Dictyostelium discoideum)
TCEA1 [nucleoplasm]
(Drosophila melanogaster)
TCEA1 [nucleoplasm]
(Gallus gallus)
TCEA1 [nucleoplasm]
(Mus musculus)
TCEA1 [nucleoplasm]
(Rattus norvegicus)
TCEA1 [nucleoplasm]
(Saccharomyces cerevisiae)
TCEA1 [nucleoplasm]
(Schizosaccharomyces pombe)
TCEA1 [nucleoplasm]
(Sus scrofa)
tcea1 [nucleoplasm]
(Danio rerio)
tcea1 [nucleoplasm]
(Xenopus tropicalis)
LYPLA1 [nucleoplasm]
(Canis familiaris)
Ghost homologue of TCEA1 [nucleoplasm]
(Plasmodium falciparum)
Cross References
RefSeq
NP_006747.1
,
NP_958845.1
ENSEMBL
ENSP00000428426
,
ENST00000521604
,
ENST00000396401
,
ENSP00000395483
OpenTargets
ENSG00000187735
HPA
ENSG00000187735-TCEA1
PRO
P23193
Pharos - Targets
P23193
GlyGen
P23193
PDB
5IY6
,
8A40
,
8UIS
,
7UNC
,
3NDQ
,
6O9L
,
6ZUY
,
7CNF
,
6ZV4
,
1TFI
,
5IYC
,
5IYB
,
5IYA
,
5IY8
,
5IY7
,
7UND
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24928 POLR2A
7
POLR2A [nucleoplasm]
(R-HSA-63502)
p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-113420)
p-3S-POLR2A [nucleoplasm]
(R-HSA-6797701)
Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-6781855)
p-S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-77100)
p-S5,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6810226)
p-S2,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6814543)
0.708
5
UniProt:Q8N7H5 PAF1
1
PAF1 [nucleoplasm]
(R-HSA-8866689)
0.577
4
UniProt:Q8WVC0 LEO1
1
LEO1 [nucleoplasm]
(R-HSA-3322361)
0.577
4
UniProt:Q5VW32 BROX
0.564
2
UniProt:Q92917 GPKOW
1
GPKOW [nucleoplasm]
(R-HSA-8850839)
0.556
3
UniProt:Q4G0J3 LARP7
0.483
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text