Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TDG [nucleoplasm]
Stable Identifier
R-HSA-65812
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.-)
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depyrimidination (Homo sapiens)
Cleavage of the damaged pyrimidine (Homo sapiens)
Cleavage of ethenocytosine by TDG glycosylase (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:EtCYT-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
Cleavage of thymine by TDG glycosylase (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:(T:G)-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
Cleavage of uracil by TDG glycosylase (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:(Ura:Gua)-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
TDG glycosylase mediated recognition and binding of a thymine opposite to a guanine (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:(T:G)-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG glycosylase mediated recognition and binding of an ethenocytosine (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:EtCYT-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:(Ura:Gua)-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Displacement of DNA glycosylase by APEX1 (Homo sapiens)
Displacement of TDG glycosylase by APEX1 at the AP site (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
TET1,2,3 and TDG demethylate DNA (Homo sapiens)
TDG excises 5-carboxylcytosine (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG excises 5-formylcytosine (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
SUMOylation of TDG with SUMO1 (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
SUMOylation of TDG with SUMO2,3 (Homo sapiens)
TDG [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13569 TDG
Gene Names
TDG
Chain
chain:1-410
Reference Genes
BioGPS Gene:6996 TDG
COSMIC (genes):TDG TDG
CTD Gene:6996 TDG
dbSNP Gene:6996 TDG
ENSEMBL:ENSG00000139372 TDG
HGNC:11700 TDG
Monarch:6996 TDG
NCBI Gene:6996 TDG
OMIM:601423 TDG
UCSC:Q13569 TDG
Reference Transcript
RefSeq:NM_003211.4 TDG
Other Identifiers
11746509_a_at
11758036_s_at
11761192_a_at
16756111
203742_PM_s_at
203743_PM_s_at
203743_s_at
3373603
3408686
3408687
3408690
3408691
3408693
3408694
3408697
3429366
3429367
3429369
3429372
3429373
3429374
3429375
3429377
3429378
3429379
3429380
3429381
3429383
3429384
3429385
3429386
3429387
40865_at
6996
7958147
A_14_P110025
A_14_P129081
A_14_P138419
A_23_P204579
A_24_P526177
A_33_P3357445
GE81245
GO:0000122
GO:0000287
GO:0000700
GO:0003676
GO:0003677
GO:0003684
GO:0003690
GO:0003712
GO:0003824
GO:0004844
GO:0005080
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005886
GO:0006281
GO:0006284
GO:0006285
GO:0006325
GO:0006355
GO:0008263
GO:0016605
GO:0016787
GO:0019104
GO:0019904
GO:0030983
GO:0031402
GO:0031404
GO:0032183
GO:0040029
GO:0043226
GO:0043739
GO:0045008
GO:0045995
GO:0055086
GO:0060090
GO:0140097
GO:0140110
GO:0140297
GO:0141016
GO:0141167
GO:1901135
HMNXSV003003285
HMNXSV003007708
ILMN_1777096
ILMN_1782331
PH_hs_0030709
TC12000254.hg
TC12000804.hg
TC12002547.hg
U51166_at
g4507422_3p_a_at
Participates
as an input of
SUMOylation of TDG with SUMO2,3 (Homo sapiens)
SUMOylation of TDG with SUMO1 (Homo sapiens)
TDG excises 5-carboxylcytosine (Homo sapiens)
TDG excises 5-formylcytosine (Homo sapiens)
TDG glycosylase mediated recognition and binding of an ethenocytosine (Homo sapiens)
TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)
TDG glycosylase mediated recognition and binding of a thymine opposite to a guanine (Homo sapiens)
as an output of
Displacement of TDG glycosylase by APEX1 at the AP site (Homo sapiens)
as a component of
TDG:EtCYT-dsDNA [nucleoplasm] (Homo sapiens)
TDG:(Ura:Gua)-dsDNA [nucleoplasm] (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
TDG:(T:G)-dsDNA [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K330-TDG [nucleoplasm]
polySUMO2,3-K330-TDG [nucleoplasm]
Inferred To
TDG [nucleoplasm]
(Bos taurus)
TDG [nucleoplasm]
(Canis familiaris)
TDG [nucleoplasm]
(Gallus gallus)
TDG [nucleoplasm]
(Sus scrofa)
tdg [nucleoplasm]
(Xenopus tropicalis)
thp1 [nucleoplasm]
(Schizosaccharomyces pombe)
tdg.1 [nucleoplasm]
(Danio rerio)
Tdg [nucleoplasm]
(Drosophila melanogaster)
Tdg [nucleoplasm]
(Mus musculus)
Tdg [nucleoplasm]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000139372
ENSEMBL
ENST00000392872
,
ENSP00000376611
IntEnz
3.2.2.29
HPA
ENSG00000139372-TDG
PRO
Q13569
Pharos - Targets
Q13569
HMDB Protein
HMDBP09192
PDB
1WYW
,
5CYS
,
4Z7Z
,
4Z47
,
6U15
,
5HF7
,
4Z7B
,
6U17
,
4JGC
,
3UO7
,
5T2W
,
4Z3A
,
6U16
,
4XEG
,
3UFJ
,
3UOB
,
4FNC
,
5JXY
,
2RBA
,
2D07
,
5FF8
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
SUMO1 [nucleoplasm]
(R-HSA-877304)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
0.667
3
UniProt:Q15788 NCOA1
3
NCOA1 [nucleoplasm]
(R-HSA-442496)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
0.576
8
UniProt:Q9GZX7 AICDA
1
AICDA [nucleoplasm]
(R-HSA-452477)
0.576
5
UniProt:P61956 SUMO2
6
lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm]
(R-HSA-9761546)
UBE2I-G93-SUMO2 [nucleoplasm]
(R-HSA-3730625)
SUMO2 [nucleoplasm]
(R-HSA-2984281)
lysyl-G93-SUMO2 [cytosol]
(R-HSA-9834803)
UBA2-G93-SUMO2 [nucleoplasm]
(R-HSA-3730618)
SUMO2(1-95) [nucleoplasm]
(R-HSA-2990837)
0.558
2
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P02766 TTR
2
TTR [azurophil granule lumen]
(R-HSA-6799366)
TTR [extracellular region]
(R-HSA-976883)
0.556
3
UniProt:Q92870-2 Q928702
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:A0A6Q8PF08 A0A6Q8PF08
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:P07196 NEFL
1
NEFL [cytosol]
(R-HSA-432284)
0.556
3
UniProt:P60891 PRPS1
1
PRPS1 [cytosol]
(R-HSA-73483)
0.556
3
UniProt:P24522 GADD45A
1
GADD45A [nucleoplasm]
(R-HSA-3215139)
0.524
3
UniProt:O88846
1
RNF4 [cytosol]
(R-RNO-975974)
0.499
2
UniProt:PGR ENSG00000082175
0.499
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text