Reactome | GTF2B [nucleoplasm]

GTF2B [nucleoplasm]

Stable Identifier

R-HSA-65888

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TFIIB, Transcription initiation factor IIB (General transcription factor TFIIB) (S300-II), Transcription initiation factor IIB, General transcription factor TFIIB, S300-II

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q00403 GTF2B

Gene Names

GTF2B, TF2B, TFIIB

Chain

chain:1-316

Reference Genes

BioGPS Gene:2959 GTF2B

COSMIC (genes):GTF2B GTF2B

CTD Gene:2959 GTF2B

dbSNP Gene:2959 GTF2B

ENSEMBL:ENSG00000137947 GTF2B

HGNC:4648 GTF2B

KEGG:hsa:2959 GTF2B

Monarch:2959 GTF2B

NCBI Gene:2959 GTF2B

OMIM:189963 GTF2B

UCSC:Q00403 GTF2B

Reference Transcript

RefSeq:NM_001514.5 GTF2B

Other Identifiers

1070_at

11716986_a_at

16689275

208066_PM_s_at

208066_s_at

2421754

2421755

2421756

2421759

2421760

2421761

2421762

2421763

2421764

2421773

2421775

2421776

2421777

2421779

2959

37380_at

37381_g_at

7917472

A_23_P34628

GE59841

GO:0000776

GO:0000793

GO:0000979

GO:0000993

GO:0001174

GO:0003677

GO:0003824

GO:0004402

GO:0005515

GO:0005634

GO:0005654

GO:0005669

GO:0005694

GO:0006325

GO:0006338

GO:0006351

GO:0006352

GO:0006366

GO:0006367

GO:0006473

GO:0007010

GO:0008270

GO:0010467

GO:0016251

GO:0016407

GO:0016604

GO:0016740

GO:0016746

GO:0017025

GO:0019083

GO:0032153

GO:0032993

GO:0042585

GO:0043226

GO:0046872

GO:0046966

GO:0051123

GO:0051177

GO:0051225

GO:0051276

GO:0061733

GO:0065003

GO:0070897

GO:0090575

GO:0097550

GO:0140096

GO:0140223

GO:0140297

GO:1904798

GO:1990114

GO:1990841

HMNXSV003035850

ILMN_1737857

M76766_at

PH_hs_0013567

PH_hs_0032359

TC01002843.hg

g13435384_3p_s_at

Participates

as an input of

as a component of

as an output of

Inferred To

gtf2b [nucleoplasm] (Danio rerio)

gtf2b [nucleoplasm] (Xenopus tropicalis)

GTF2B [nucleoplasm] (Bos taurus)

GTF2B [nucleoplasm] (Caenorhabditis elegans)

GTF2B [nucleoplasm] (Canis familiaris)

GTF2B [nucleoplasm] (Dictyostelium discoideum)

GTF2B [nucleoplasm] (Drosophila melanogaster)

GTF2B [nucleoplasm] (Gallus gallus)

GTF2B [nucleoplasm] (Mus musculus)

GTF2B [nucleoplasm] (Rattus norvegicus)

GTF2B [nucleoplasm] (Saccharomyces cerevisiae)

GTF2B [nucleoplasm] (Schizosaccharomyces pombe)

GTF2B [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001505.1

OpenTargets

ENSG00000137947

ENSEMBL

ENSP00000359531, ENST00000370500

IntEnz

2.3.1.48

HPA

ENSG00000137947-GTF2B

PRO

Q00403

Pharos - Targets

Q00403

GlyGen

Q00403

PDB

8WAN, 1TFB, 8S5N, 7ZWC, 7NW0, 8S52, 7NVY, 7EG9, 1RO4, 7NVT, 8S51, 7EGA, 7EGC, 8BVW, 6O9L, 1C9B, 7ZX8, 1DL6, 8BZ1, 8BYQ, 5WH1, 5IY8, 5IYA, 7LBM, 7EDX, 5IY7, 5IYB, 8WAR, 5IYD, 8WAK, 8WAP, 8WAS, 8WAO, 8WAQ, 1VOL, 1RLY, 7NVR, 7NVZ, 7NVU, 7NVS, 8GXS, 8GXQ, 7EGB, 7ZX7, 2PHG, 7ENA, 7ENC, 5IY6, 7ZXE, 7EG7, 5IY9, 7ZWD, 5IYC, 7EG8, 8WAL

Interactors (67)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.781	7
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.736	6
UniProt:Q14919 DRAP1	1	DRAP1 [nucleoplasm] (R-HSA-1226029)	0.718	6
UniProt:P03122 VE2			0.683	3
UniProt:P03120 VE2			0.667	3
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.589	2
UniProt:P62701 RPS4X	2	RPS4X [cytosol] (R-HSA-72375) RPS4X [nucleoplasm] (R-HSA-6798713)	0.556	3
UniProt:Q96MN9-2 Q96MN92			0.556	3
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.556	3
UniProt:O15381-5 O153815			0.556	3
UniProt:Q14693 LPIN1	3	LPIN1 [endoplasmic reticulum membrane] (R-HSA-549157) LPIN1 [nuclear envelope] (R-HSA-4419927) p-S106-LPIN1 [nucleoplasm] (R-HSA-4419936)	0.556	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.556	3
UniProt:Q14781-2 CBX2			0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.556	3
UniProt:O75604-3 USP2			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q3KNS6-3 Q3KNS63			0.556	3
UniProt:P60896 SEM1	2	SEM1 [cytosol] (R-HSA-8866674) SEM1 [nucleoplasm] (R-HSA-8866665)	0.556	3
UniProt:P10073 ZSC22			0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:O60506-4 SYNCRIP			0.556	3
UniProt:Q9BUL9 RPP25	1	RPP25 [nucleoplasm] (R-HSA-5696782)	0.556	3
IntAct:EBI-25831191 CCSB			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
IntAct:EBI-25835277 CCSB			0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:Q9HCC6 HES4			0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:P58304 VSX2			0.556	3
UniProt:Q5TAQ9-2 Q5TAQ92			0.556	3
UniProt:Q8NHS9 SPT22			0.556	3
UniProt:Q7Z2T5 TRM1L			0.556	3
UniProt:Q17RN3 FA98C			0.556	3
UniProt:Q92613 JADE3	1	PHF16 [nucleoplasm] (R-HSA-3321851)	0.556	3
UniProt:Q8TCT7-2 SPPL2B			0.556	3
UniProt:Q15049 MLC1			0.556	3
UniProt:Q9H972-2 C14ORF93			0.556	3
UniProt:P13928 ANXA8			0.556	3
UniProt:Q8NBB4-2 ZSCAN1			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:Q96D59 RN183			0.556	3
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:O43615 TIMM44	1	TIMM44(?-452) [mitochondrial inner membrane] (R-HSA-1252038)	0.556	3
UniProt:P10589 NR2F1	1	NR2F1 [nucleoplasm] (R-HSA-376280)	0.544	3
UniProt:P87662 P87662			0.544	3
UniProt:P03070 LT			0.544	3
UniProt:P17473 ICP4			0.544	4
UniProt:P01591 JCHAIN	1	JCHAIN [extracellular region] (R-HSA-8858030)	0.527	2
UniProt:P09228 CYTT			0.527	2
UniProt:P61218 POLR2F	2	POLR2F [cytosol] (R-HSA-1964441) POLR2F [nucleoplasm] (R-HSA-83714)	0.527	2
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.527	2
UniProt:Q96DA0 PAUF			0.527	2
UniProt:P01037 CYTN			0.527	2
UniProt:P01036 CYTS			0.527	2
UniProt:P01833 PIGR	2	PIGR(19-603) [plasma membrane] (R-HSA-197861) PIGR(19-603) [azurophil granule membrane] (R-HSA-6799166)	0.527	2
UniProt:P01876 IGHA1	1	IGHA1 [extracellular region] (R-HSA-1478809)	0.527	2
UniProt:P04745 AMY1A			0.527	2
UniProt:P62487 POLR2G	1	POLR2G [nucleoplasm] (R-HSA-63517)	0.527	2
UniProt:P19387 POLR2C	1	POLR2C [nucleoplasm] (R-HSA-63506)	0.527	2
UniProt:Q8TAX7 MUC7	18	GalNAc-MUC7 [plasma membrane] (R-HSA-8858421) Core 2 (MUC7) [Golgi lumen] (R-HSA-1462355) Core 2a (MUC7) [Golgi lumen] (R-HSA-6784289) GalNAc-MUC7 [Golgi lumen] (R-HSA-1463434) Sialyl Tn antigen (MUC7) [Golgi lumen] (R-HSA-1463593) T-antigen (MUC7) [Golgi lumen] (R-HSA-1462182) Sialyl-2,3 T-antigen (MUC7) [Golgi lumen] (R-HSA-1463543) Sialyl T-antigen (MUC7) [Golgi lumen] (R-HSA-1463514) Disialyl T-antigen (MUC7) [Golgi lumen] (R-HSA-1463600) MUC7 [Golgi lumen] (R-HSA-913667) Core 6 (MUC7) [Golgi lumen] (R-HSA-1462215) extended Core 6 (MUC7) [Golgi lumen] (R-HSA-1967030) Core 7 (MUC7) [Golgi lumen] (R-HSA-1462342) Core 3 (MUC7) [Golgi lumen] (R-HSA-1462191) Core 4 (MUC7) [Golgi lumen] (R-HSA-1462208) Core 5 (MUC7) [Golgi lumen] (R-HSA-1462294) Core 2S (MUC7) [Golgi lumen] (R-HSA-6786322) Core 8 (MUC7) [Golgi lumen] (R-HSA-1462131)	0.527	2
UniProt:P30740 SERPINB1	2	SERPINB1 [extracellular region] (R-HSA-6804818) SERPINB1 [secretory granule lumen] (R-HSA-6804786)	0.527	2
UniProt:P48281	2	polySUMO2-VDR [nucleoplasm] (R-MMU-4546376) VDR [nucleoplasm] (R-MMU-375512)	0.508	2

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