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TNFSF10 [extracellular region]
Stable Identifier
R-HSA-66186
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
TRAIL, Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis inducing ligand) (TRAIL protein) (Apo-2 ligand) (Apo-2L), Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis inducing ligand, TRAIL protein, Apo-2 ligand, Apo-2L
Icon
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing in the DISC (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
Dimerization of procaspase-8 (Homo sapiens)
TRAIL-mediated dimerization of procaspase-8 (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK3 binds RIPK1 (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
CASP8 activity is inhibited (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TRAIL signaling (Homo sapiens)
TRAIL binds TRAIL receptors (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
TRAIL:TRAIL receptor trimers bind FADD (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD:CASP10(1-521) [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
Trimerization of TRAIL:TRAIL receptor complex (Homo sapiens)
TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
TNFSF10 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50591 TNFSF10
Gene Names
TNFSF10, APO2L, TRAIL
Chain
chain:1-281
Reference Genes
COSMIC (genes):TNFSF10 TNFSF10
ENSEMBL:ENSG00000121858 TNFSF10
HGNC:11925 TNFSF10
UCSC:P50591 TNFSF10
Other Identifiers
11743730_at
11743731_a_at
11747952_x_at
16961616
1715_at
202687_PM_s_at
202687_s_at
202688_PM_at
202688_at
214329_3p_x_at
214329_PM_x_at
214329_x_at
2705705
2705707
2705708
2705709
2705710
2705711
2705712
2705713
2705714
2705717
2705718
2705719
2705720
2705725
2705728
2705729
2705730
8092169
8743
A_21_P0000113
A_23_P121253
A_33_P3226810
GE59115
GO:0002376
GO:0005102
GO:0005125
GO:0005164
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006915
GO:0006955
GO:0007154
GO:0007165
GO:0007267
GO:0008270
GO:0008584
GO:0012501
GO:0016020
GO:0022414
GO:0023052
GO:0032813
GO:0032868
GO:0036462
GO:0042802
GO:0043065
GO:0043123
GO:0043226
GO:0043280
GO:0045569
GO:0046872
GO:0048018
GO:0048856
GO:0070062
GO:0090200
GO:0098772
GO:2001238
HMNXSV003012780
HMNXSV003055767
Hs.301527.0.A1_3p_x_at
ILMN_1801307
ILMN_1903064
PH_hs_0024437
TC03002006.hg
TC03003211.hg
U37518_at
g1336207_3p_a_at
Participates
as an input of
TRAIL binds TRAIL receptors (Homo sapiens)
as a component of
TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)
Inferred To
Ghost homologue of TNFSF10 [extracellular region]
(Sus scrofa)
TNFSF10 [extracellular region]
(Bos taurus)
TNFSF10 [extracellular region]
(Canis familiaris)
TNFSF10 [extracellular region]
(Danio rerio)
TNFSF10 [extracellular region]
(Gallus gallus)
TNFSF10 [extracellular region]
(Mus musculus)
TNFSF10 [extracellular region]
(Rattus norvegicus)
TNFSF10 [extracellular region]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSP00000389931
,
ENST00000241261
,
ENST00000420541
,
ENSP00000241261
OpenTargets
ENSG00000121858
HPA
ENSG00000121858-TNFSF10
PRO
P50591
Pharos - Targets
P50591
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14763 TNFRSF10B
1
TNFRSF10B [plasma membrane]
(R-HSA-65505)
0.946
25
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.919
20
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.913
19
UniProt:O15519-2 CFLAR
1
FLIP(S) [cytosol]
(R-HSA-3465357)
0.725
7
UniProt:O15519-1 CFLAR
5
M1polyUb-K351,K353-CFLAR(1-480) [cytosol]
(R-HSA-9794015)
CFLAR(377-480) [cytosol]
(R-HSA-3465483)
K63polyUb-CFLAR(1-480) [cytosol]
(R-HSA-9818805)
CFLAR(1-376) [cytosol]
(R-HSA-3465408)
CFLAR(1-480) [cytosol]
(R-HSA-3371356)
0.725
8
UniProt:O00220 TNFRSF10A
1
TNFRSF10A [plasma membrane]
(R-HSA-5633393)
0.723
8
UniProt:O15519 CFLAR
1
CFLAR(1-376) [cytosol]
(R-HSA-51925)
0.527
2
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