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FASLG(1-281) [extracellular region]
Stable Identifier
R-HSA-66212
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
FASL, Tumor necrosis factor ligand superfamily member 6 (FAS antigen ligand) (Apoptosis antigen ligand) (APTL) (CD178 antigen), Tumor necrosis factor ligand superfamily member 6, FAS antigen ligand, Apoptosis antigen ligand, APTL, CD178 antigen
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
FASLG (FasL) gene expression (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell death genes (Homo sapiens)
FASLG gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of FASLG (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing in the DISC (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
Dimerization of procaspase-8 (Homo sapiens)
FAS-mediated dimerization of procaspase-8 (Homo sapiens)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK3 binds RIPK1 (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
CASP8 activity is inhibited (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
FasL/ CD95L signaling (Homo sapiens)
FASL binds FAS Receptor (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-10 [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FasL:Fas binds FADD (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
Trimerization of the FASL:FAS receptor complex (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FASLG(1-281) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48023 FASLG
Gene Names
FASLG, APT1LG1, CD95L, FASL, TNFSF6
Chain
chain:1-281, chain:1-129, chain:1-81, chain:130-281
Reference Genes
COSMIC (genes):FASLG FASLG
ENSEMBL:ENSG00000117560 FASLG
HGNC:11936 FASLG
UCSC:P48023 FASLG
Other Identifiers
11732555_at
11732556_a_at
16673928
1851_s_at
1858_at
210865_PM_at
210865_at
211333_PM_s_at
211333_s_at
2367606
2367607
2367608
2367609
2367610
2367611
2367616
2367617
356
7907430
A_14_P105867
A_23_P369815
A_24_P54220
D38122_at
GE784965
GO:0000122
GO:0002376
GO:0005102
GO:0005123
GO:0005125
GO:0005164
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005764
GO:0005773
GO:0005886
GO:0005901
GO:0006355
GO:0006915
GO:0006919
GO:0006925
GO:0006955
GO:0007154
GO:0007165
GO:0007267
GO:0008284
GO:0008625
GO:0009897
GO:0009986
GO:0012501
GO:0016020
GO:0016525
GO:0023052
GO:0030644
GO:0031410
GO:0032496
GO:0043065
GO:0043123
GO:0043202
GO:0043226
GO:0043525
GO:0045742
GO:0046666
GO:0048018
GO:0048388
GO:0048471
GO:0055085
GO:0060205
GO:0061024
GO:0070062
GO:0070231
GO:0070266
GO:0070848
GO:0071346
GO:0097190
GO:0097191
GO:0097527
GO:0098772
GO:1903514
GO:1905782
GO:2000353
HMNXSV003052998
ILMN_1781824
PH_hs_0000267
TC01001506.hg
U11821_s_at
g12597288_3p_a_at
g601892_3p_at
Participates
as an output of
Expression of FASLG (Homo sapiens)
FASLG (FasL) gene expression (Homo sapiens)
FASLG gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)
as an input of
FASL binds FAS Receptor (Homo sapiens)
as a component of
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
Inferred To
Faslg [extracellular region]
(Mus musculus)
Faslg [extracellular region]
(Rattus norvegicus)
LOC407111 [extracellular region]
(Bos taurus)
FASLG [extracellular region]
(Canis familiaris)
FASLG(1-281) [extracellular region]
(Gallus gallus)
FASLG(1-281) [extracellular region]
(Sus scrofa)
faslg [extracellular region]
(Danio rerio)
faslg [extracellular region]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000117560
ENSEMBL
ENSP00000344739
,
ENSP00000356694
,
ENST00000367721
,
ENST00000340030
HPA
ENSG00000117560-FASLG
PRO
P48023
Pharos - Targets
P48023
GlyGen
P48023
Orphanet
FASLG
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.744
5
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.731
4
UniProt:Q8WV41 SNX33
0.723
5
UniProt:O76081-6 RGS20
0.718
6
UniProt:O43586 PSTPIP1
1
PSTPIP1 [cytosol]
(R-HSA-879220)
0.697
5
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.683
4
UniProt:P25445 FAS
1
FAS [plasma membrane]
(R-HSA-66248)
0.65
4
UniProt:P16333-1 NCK1
0.623
4
UniProt:O75044 SRGAP2
1
SRGAP2 [cytosol]
(R-HSA-195131)
0.609
2
UniProt:Q9UKS6 PACSIN3
1
PACSIN3 [cytosol]
(R-HSA-8868270)
0.591
4
UniProt:Q91ZR2
1
SNX18 [cytosol]
(R-MMU-8868038)
0.591
4
UniProt:Q15642 TRIP10
1
TRIP10 [cytosol]
(R-HSA-195120)
0.591
4
UniProt:Q96RU3 FNBP1
1
FNBP1 [cytosol]
(R-HSA-8862261)
0.591
4
UniProt:Q9UNF0 PACSIN2
1
PACSIN2 [cytosol]
(R-HSA-8868267)
0.591
4
UniProt:Q9BY11 PACSIN1
1
PACSIN1 [cytosol]
(R-HSA-8868269)
0.591
4
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.571
2
UniProt:P06241 FYN
6
FYN [cytosol]
(R-HSA-200917)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
0.571
2
UniProt:Q16610 ECM1
2
ECM1 [extracellular region]
(R-HSA-8848909)
ECM1 [platelet dense granule lumen]
(R-HSA-8848880)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q63HR2 TENS2
0.556
3
UniProt:A0A0S2Z4D7 A0A0S2Z4D7
0.556
3
UniProt:O76081 RGS20
1
RGS20 [plasma membrane]
(R-HSA-921136)
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:Q15436 SEC23A
4
SEC23A [endoplasmic reticulum membrane]
(R-HSA-203976)
SEC23A [cytosol]
(R-HSA-203972)
SEC23A [ER to Golgi transport vesicle membrane]
(R-HSA-204024)
p-S738,T744 SEC23A [cytosol]
(R-HSA-5685740)
0.556
3
UniProt:Q14525 KRT33B
1
KRT33B [cytosol]
(R-HSA-6809594)
0.556
3
UniProt:P60328 KRTAP12-3
1
KRTAP12-3 [cytosol]
(R-HSA-6810284)
0.556
3
UniProt:Q15654 TRIP6
0.556
3
UniProt:Q8IYA8 IHO1
0.556
3
UniProt:Q8IUC1 KRTAP11-1
1
KRTAP11-1 [cytosol]
(R-HSA-6810294)
0.556
3
UniProt:Q08881 ITK
3
ITK [cytosol]
(R-HSA-202319)
p-Y512-ITK [cytosol]
(R-HSA-422519)
p-Y180,Y512-ITK [cytosol]
(R-HSA-2685616)
0.544
3
UniProt:Q8IVL6 P3H3
1
LEPREL2 [endoplasmic reticulum lumen]
(R-HSA-1650821)
0.527
2
UniProt:Q8NHP6 MOSPD2
3
MOSPD2 [endosome membrane]
(R-HSA-9715095)
MOSPD2 [plasma membrane]
(R-HSA-6806308)
MOSPD2 [specific granule membrane]
(R-HSA-6799635)
0.527
2
UniProt:P55345 ANM2
0.527
3
UniProt:Q9Y5X1 SNX9
3
SNX9 [cytosol]
(R-HSA-8867737)
SNX9 [Golgi membrane]
(R-HSA-432988)
SNX9 [cytoplasmic vesicle membrane]
(R-HSA-432990)
0.524
2
UniProt:Q9DBG3
5
Ap2b1 [endolysosome membrane]
(R-MMU-6784827)
Ap2b1 [clathrin-coated endocytic vesicle membrane]
(R-MMU-2130489)
Ap2b1 [cytosol]
(R-MMU-182166)
Ap2b1 [plasma membrane]
(R-MMU-167690)
Ap2b1 [endocytic vesicle membrane]
(R-MMU-416642)
0.499
2
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