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TNF(1-233) [plasma membrane]
Stable Identifier
R-HSA-66220
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TNF-alpha, Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (Cachectin), Tumor necrosis factor precursor, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
2xTNFR2 binds TNFA trimer:TNFR2 (Homo sapiens)
TNFA trimer:TNFR2 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFA trimer:TNFR2 trimer [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
TNFA trimer:TNFR2 trimer [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
TNFA trimer:TNFR2 trimer [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
TNFA trimer:TNFR2 trimer [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
TNFA trimer:TNFR2 trimer [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFA binds TNFR2 (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFA trimer:TNFR2 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA trimer:TNFR2 trimer [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
TNFA trimer:TNFR2 trimer [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
TNFA trimer:TNFR2 trimer [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Homo sapiens)
TNFA trimer:TNFR2 trimer [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA trimer:TNFR2 trimer [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
TNF signaling (Homo sapiens)
Membrane-anchored TNF-alpha binds TNFR1 (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
RIPK1 is deubiquitinated (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 binds DENN/MADD (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:DENN-SV,MADD [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Homo sapiens)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha is cleaved by ADAM17 (TACE) (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFR1-induced NFkappaB signaling pathway (Homo sapiens)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFalpha:TNF-R1:TRADD:K63polyUb-RIP1:BIRC2/3:IKKA:IKKB:NEMO [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNFR1-mediated ceramide production (Homo sapiens)
TNF-alpha:TNFR1 binds NSMAF (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF binds GNB2L1 (Homo sapiens)
TNF-alpha:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1:SMPD2,3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
TNF(1-233) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01375 TNF
Gene Names
TNF, TNFA, TNFSF2
Chain
chain:1-233, chain:1-39, chain:1-35, chain:50-, chain:52-, chain:77-233
Reference Genes
BioGPS Gene:7124 TNF
COSMIC (genes):TNF TNF
CTD Gene:7124 TNF
dbSNP Gene:7124 TNF
ENSEMBL:ENSG00000204490 TNF
ENSEMBL:ENSG00000206439 TNF
ENSEMBL:ENSG00000223952 TNF
ENSEMBL:ENSG00000228321 TNF
ENSEMBL:ENSG00000228849 TNF
ENSEMBL:ENSG00000230108 TNF
ENSEMBL:ENSG00000232810 TNF
HGNC:11892 TNF
KEGG Gene (Homo sapiens):7124 TNF
Monarch:7124 TNF
NCBI Gene:7124 TNF
OMIM:191160 TNF
Reference Transcript
RefSeq:NM_000594.3 TNF
Other Identifiers
0002450619
11721577_at
17006659
17026267
17027794
17030620
17033337
17035418
17038117
17040712
1852_at
207113_s_at
259_s_at
2902417
2902418
2902420
2902421
2902423
2902424
7124
8118142
8177983
8179263
A_14_P110091
A_14_P125975
A_23_P376488
A_24_P50759
GE59636
GO:0000122
GO:0000165
GO:0000185
GO:0000187
GO:0000278
GO:0000976
GO:0001774
GO:0001819
GO:0001891
GO:0001932
GO:0001934
GO:0001937
GO:0002020
GO:0002376
GO:0002439
GO:0002637
GO:0002719
GO:0002876
GO:0002925
GO:0003674
GO:0003677
GO:0005125
GO:0005164
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005768
GO:0005886
GO:0005887
GO:0005975
GO:0006006
GO:0006357
GO:0006412
GO:0006464
GO:0006629
GO:0006810
GO:0006919
GO:0006950
GO:0006952
GO:0006954
GO:0006955
GO:0006959
GO:0007010
GO:0007049
GO:0007155
GO:0007165
GO:0007249
GO:0007254
GO:0007267
GO:0007275
GO:0008150
GO:0008219
GO:0008283
GO:0008625
GO:0008630
GO:0009056
GO:0009058
GO:0009615
GO:0009651
GO:0009790
GO:0009887
GO:0009897
GO:0009986
GO:0010033
GO:0010573
GO:0010628
GO:0010629
GO:0010693
GO:0010803
GO:0010888
GO:0014068
GO:0015031
GO:0016020
GO:0016021
GO:0016192
GO:0019221
GO:0019899
GO:0022607
GO:0030154
GO:0030198
GO:0030316
GO:0030730
GO:0030866
GO:0031334
GO:0031410
GO:0031622
GO:0031663
GO:0032715
GO:0032722
GO:0032724
GO:0032729
GO:0032731
GO:0032755
GO:0032757
GO:0033138
GO:0033209
GO:0034116
GO:0034330
GO:0034641
GO:0035509
GO:0040011
GO:0042127
GO:0042531
GO:0042592
GO:0042742
GO:0042802
GO:0043065
GO:0043068
GO:0043122
GO:0043123
GO:0043154
GO:0043226
GO:0043242
GO:0043243
GO:0043280
GO:0043406
GO:0043491
GO:0043507
GO:0043525
GO:0043537
GO:0044281
GO:0044403
GO:0045071
GO:0045121
GO:0045123
GO:0045429
GO:0045598
GO:0045599
GO:0045662
GO:0045668
GO:0045670
GO:0045672
GO:0045732
GO:0045785
GO:0045860
GO:0045892
GO:0045893
GO:0045930
GO:0045944
GO:0045994
GO:0046325
GO:0046330
GO:0046427
GO:0048143
GO:0048566
GO:0048646
GO:0048661
GO:0048856
GO:0048870
GO:0050708
GO:0050727
GO:0050729
GO:0050766
GO:0050768
GO:0050796
GO:0050806
GO:0050807
GO:0050830
GO:0050877
GO:0050890
GO:0050900
GO:0050901
GO:0050995
GO:0051000
GO:0051044
GO:0051091
GO:0051092
GO:0051173
GO:0051222
GO:0051384
GO:0051798
GO:0051897
GO:0051966
GO:0055037
GO:0055085
GO:0060252
GO:0060557
GO:0060559
GO:0060664
GO:0060693
GO:0061044
GO:0061048
GO:0065003
GO:0070374
GO:0070886
GO:0071222
GO:0071230
GO:0071316
GO:0071407
GO:0071550
GO:0071677
GO:0071803
GO:0072577
GO:0072659
GO:0097190
GO:0097191
GO:0097527
GO:0150078
GO:0150129
GO:1900017
GO:1900222
GO:1901224
GO:1901647
GO:1901671
GO:1902004
GO:1902895
GO:1903078
GO:1903140
GO:1903347
GO:1903721
GO:1903799
GO:1904707
GO:1904996
GO:1904999
GO:2000010
GO:2000272
GO:2000304
GO:2000334
GO:2000343
GO:2000351
GO:2000377
GO:2001234
GO:2001238
GO:2001240
HMNXSV003051425
ILMN_1728106
PH_hs_0012958
TC06000371.hg
TC06002714.hg
TC6_apd_hap1000036.hg
TC6_cox_hap2000067.hg
TC6_dbb_hap3000058.hg
TC6_mann_hap4000059.hg
TC6_mcf_hap5000053.hg
TC6_qbl_hap6000058.hg
TC6_ssto_hap7000054.hg
X02910_at
g10835154_3p_a_at
Participates
as a component of
TNF(1-233) trimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
TNF(52-76) [extracellular region]
TNF(1-34) [plasma membrane]
TNF(1-76) [plasma membrane]
TNF(77-233) [extracellular region]
Inferred To
TNF [plasma membrane]
(Bos taurus)
TNF [plasma membrane]
(Canis familiaris)
TNF [plasma membrane]
(Sus scrofa)
tnfa [plasma membrane]
(Danio rerio)
tnfb [plasma membrane]
(Danio rerio)
Ghost homologue of TNF(1-233) [plasma membrane]
(Gallus gallus)
lta [plasma membrane]
(Xenopus tropicalis)
Homologues of TNF(1-233) [plasma membrane]
(Danio rerio)
Tnf [plasma membrane]
(Mus musculus)
Tnf [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000585.2
ZINC - World Drugs
TNFA_HUMAN
OpenTargets
ENSG00000232810
ZINC - Substances
TNFA_HUMAN
ZINC - Biogenic
TNFA_HUMAN
ZINC target
P01375
PRO
P01375
GlyGen
P01375
PDB
7ASY
,
5WUX
,
6X81
,
7AT7
,
6X82
,
1A8M
,
4TWT
,
2E7A
,
2TUN
,
6X83
,
3ALQ
,
7ATB
,
4Y6O
,
4TSV
,
5YOY
,
6X85
,
1TNF
,
5MU8
,
2ZPX
,
6X86
,
7KP9
,
7JRA
,
3IT8
,
6RMJ
,
5M2I
,
2AZ5
,
6OP0
,
4G3Y
,
2ZJC
,
6OOY
,
7KPA
,
5M2J
,
5M2M
,
7KPB
,
6OOZ
,
3L9J
,
5UUI
,
5TSW
,
3WD5
ZINC - Investigational
TNFA_HUMAN
ZINC - Metabolites
TNFA_HUMAN
HPA
ENSG00000232810-TNF
GeneCards
P01375
Ensembl
ENST00000443707
,
ENSG00000232810
,
ENSP00000389492
,
ENST00000383496
,
ENST00000448781
,
ENSP00000389490
,
ENST00000449264
,
ENSP00000392858
,
ENSG00000230108
,
ENSP00000365290
,
ENSG00000204490
,
ENST00000420425
,
ENSG00000228321
,
ENSP00000372988
,
ENSP00000410668
,
ENSP00000398698
,
ENST00000376122
,
ENSG00000228849
,
ENST00000412275
,
ENSG00000206439
,
ENSG00000223952
Pharos - Targets
P01375
ZINC - Predictions - Purchasable
TNFA_HUMAN
Orphanet
16877
HMDB Protein
HMDBP02070
Interactors (52)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19438 TNFRSF1A
2
TNFRSF1A(30-45) [plasma membrane]
(R-HSA-5675738)
TNFRSF1A(41-201) [extracellular region]
(R-HSA-6785048)
0.934
15
UniProt:Q13546 RIPK1
13
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.837
9
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.788
9
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.788
5
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.73
3
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.725
7
UniProt:Q9H0F6 SHARPIN
1
SHARPIN [cytosol]
(R-HSA-5212666)
0.725
4
UniProt:Q9BYM8 RBCK1
1
RBCK1 [cytosol]
(R-HSA-976018)
0.725
6
UniProt:Q9Y6K9 IKBKG
12
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.669
3
UniProt:Q96EP0 RNF31
1
RNF31 [cytosol]
(R-HSA-5212660)
0.643
3
UniProt:Q8UYL3 Q8UYL3
0.641
3
UniProt:P20333 TNFRSF1B
3
TNFRSF1B(27-?) [plasma membrane]
(R-HSA-6785037)
TNFRSF1B [plasma membrane]
(R-HSA-5661484)
TNFRSF1B [specific granule membrane]
(R-HSA-6806149)
0.609
2
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.601
4
UniProt:Q9DHW0 Q9DHW0
0.558
2
UniProt:O75459 PAGE1
0.556
3
UniProt:Q92482 AQP3
1
AQP3 [plasma membrane]
(R-HSA-431723)
0.556
3
UniProt:Q9H7M9 VISTA
0.556
3
UniProt:Q96RD7 PANX1
1
PANX1 [plasma membrane]
(R-HSA-375344)
0.556
3
UniProt:Q6ZMZ0 RNF19B
1
RNF19B [cytosol]
(R-HSA-975969)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q16585 SGCB
0.556
3
UniProt:Q8N386 LRC25
0.556
3
UniProt:Q8IUN9 CLEC10A
1
CLEC10A [plasma membrane]
(R-HSA-1472863)
0.556
3
UniProt:Q15849 SLC14A2
1
SLC14A2 [plasma membrane]
(R-HSA-444115)
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:O43300 LRRTM2
1
LRRTM2 [plasma membrane]
(R-HSA-6797966)
0.556
3
UniProt:P00387 CYB5R3
3
CYB5R3(27-301) [azurophil granule lumen]
(R-HSA-6799217)
CYB5R3(27-301) [extracellular region]
(R-HSA-6806205)
MyrG-CYB5R3(2-301) [mitochondrial outer membrane]
(R-HSA-198771)
0.556
3
UniProt:Q8TBE3 FNDC9
0.556
3
UniProt:Q6NSX1 CCD70
0.556
3
UniProt:Q53GL0 PKHO1
0.556
3
UniProt:Q6PEW1 ZCH12
0.556
3
UniProt:Q8WWF3 SSMM1
0.556
3
UniProt:Q8N6L0 KASH5
0.556
3
UniProt:Q8N4L2 PP4P2
0.556
3
UniProt:Q6UXG8-3 Q6UXG83
0.556
3
UniProt:Q8IYJ2-2 C10ORF67
0.556
3
UniProt:Q8WV48 CC107
0.556
3
UniProt:O95471 CLDN7
2
CLDN7 [cell junction]
(R-HSA-421241)
CLDN7 [plasma membrane]
(R-HSA-420004)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P27105 STOM
4
STOM [specific granule membrane]
(R-HSA-6799569)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [tertiary granule membrane]
(R-HSA-6800960)
0.556
3
UniProt:O15552 FFAR2
1
FFAR2 [plasma membrane]
(R-HSA-443944)
0.556
3
UniProt:O15393-2 TMPRSS2
0.556
3
UniProt:O14863 ZNT4
0.556
3
UniProt:Q9BXK5 B2L13
0.556
3
UniProt:Q9HC36 MRM3
1
RNMTL1 [mitochondrial matrix]
(R-HSA-6793067)
0.556
3
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.527
2
UniProt:Q60769
1
Tnfaip3 [cytosol]
(R-MMU-688989)
0.499
2
UniProt:P25118
1
TNFRSF1A(30-45) [plasma membrane]
(R-MMU-5675738)
0.499
3
UniProt:Q60855
7
Ripk1 [cytosol]
(R-MMU-6783308)
Ripk1 [cytosol]
(R-MMU-6783197)
Ripk1 [cytosol]
(R-MMU-5212664)
Ripk1 [cytosol]
(R-MMU-5212671)
phospho-Ripk1 [cytosol]
(R-MMU-5218872)
Ripk1 [cytosol]
(R-MMU-937021)
Ripk1 [cytosol]
(R-MMU-168651)
0.499
3
UniProt:O89110
6
Casp8 [cytosol]
(R-MMU-3465404)
Casp8 [mitochondrial outer membrane]
(R-MMU-351869)
Casp8 [mitochondrial outer membrane]
(R-MMU-351828)
Casp8 [cytosol]
(R-MMU-76158)
Casp8 [cytosol]
(R-MMU-75975)
Casp8 [cytosol]
(R-MMU-57031)
0.499
2
UniProt:Q3U0V2
1
TRADD [cytosol]
(R-MMU-66376)
0.499
2
UniProt:O88351
2
phospho-Ikbkb [cytosol]
(R-MMU-202506)
Ikbkb [cytosol]
(R-MMU-168114)
0.499
3
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