Reactome | TRADD [cytosol]

TRADD [cytosol]

Stable Identifier

R-HSA-66376

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TNFR1-associated DEATH domain protein, Tumor necrosis factor receptor type 1 associated DEATH domain protein, TNFRSF1A-associated via death domain

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Locations in the PathwayBrowser

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Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
    - Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
      - Caspase-8 processing in the DISC (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
        
        DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
      - Dimerization of procaspase-8 (Homo sapiens)
        
        TNF-mediated dimerization of procaspase-8 (Homo sapiens)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
      - Regulation by c-FLIP (Homo sapiens)
        
        Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
        
        TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
- Regulated Necrosis (Homo sapiens)
  - RIPK1-mediated regulated necrosis (Homo sapiens)
    - RIPK3 binds RIPK1 (Homo sapiens)
      - DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
      - DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
    - Regulation of necroptotic cell death (Homo sapiens)
      - CASP8 activity is inhibited (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
        
        FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
      - RIPK1 is cleaved by CASP8 (Homo sapiens)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)
        
        TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Homo sapiens)
        
        TRADD [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15628 TRADD

Gene Names

TRADD

Chain

chain:1-312

Reference Genes

BioGPS Gene:8717 TRADD

COSMIC (genes):TRADD TRADD

CTD Gene:8717 TRADD

dbSNP Gene:8717 TRADD

ENSEMBL:ENSG00000102871.16 TRADD

HGNC:12030 TRADD

KEGG Gene (Homo sapiens):8717 TRADD

Monarch:8717 TRADD

NCBI Gene:8717 TRADD

OMIM:603500 TRADD

UCSC:Q15628 TRADD

Reference Transcript

Other Identifiers

0003990044

0004060180

0004570136

11725373_a_at

11760282_at

16827248

1729_PM_at

1729_at

205641_PM_s_at

205641_s_at

3695434

3695435

3695436

3695438

3695439

3695440

3695441

3695442

3695443

3695445

8001938

8717

A_23_P54649

GE57769

GO:0002947

GO:0005068

GO:0005164

GO:0005515

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006915

GO:0006954

GO:0007165

GO:0007169

GO:0008625

GO:0012501

GO:0019900

GO:0023052

GO:0030335

GO:0031264

GO:0032991

GO:0033209

GO:0042802

GO:0043065

GO:0043123

GO:0043226

GO:0043235

GO:0044877

GO:0045121

GO:0048856

GO:0048870

GO:0050729

GO:0051092

GO:0051798

GO:0060090

GO:0070513

GO:0071356

GO:0097191

GO:1901224

HMNXSV003005841

ILMN_1682489

ILMN_1747852

ILMN_1765851

ILMN_1793831

ILMN_1806800

L41690_at

PH_hs_0005024

TC16001180.hg

g13378136_3p_s_at

Participates

as a component of

as an input of

Inferred To

tradd [cytosol] (Danio rerio)

tradd [cytosol] (Xenopus tropicalis)

Tradd [cytosol] (Rattus norvegicus)

TRADD [cytosol] (Bos taurus)

TRADD [cytosol] (Canis familiaris)

TRADD [cytosol] (Gallus gallus)

TRADD [cytosol] (Mus musculus)

TRADD [cytosol] (Sus scrofa)

Ghost homologue of TRADD [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_003780.1, XP_005256270.1, NP_001310481.1, XP_016879304.1

OpenTargets

ENSG00000102871

HPA

ENSG00000102871-TRADD

GeneCards

Q15628

Ensembl

ENST00000345057, ENSP00000341268, ENSP00000462591, ENSG00000102871, ENST00000486556

PRO

Q15628

Pharos - Targets

Q15628

PDB

6AC0, 1F3V, 1F2H, 5XME, 7CSQ

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19438 TNFRSF1A	2	TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738) TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048)	0.954	15
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.942	14
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.806	7
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.796	6
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.725	7
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.725	6
UniProt:B7UI21 NLEB1			0.681	7
UniProt:P03230 LMP1			0.641	4
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.602	11
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1-polyUb, p-S25-RIPK1 [cytosol] (R-HSA-9818793) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.564	3
UniProt:Q8N163 CCAR2	2	DBC1 [nucleoplasm] (R-HSA-3371479) p-T454-DBC1 [nucleoplasm] (R-HSA-3371569)	0.564	2
UniProt:P25118	1	TNFRSF1A(30-45) [plasma membrane] (R-MMU-5675738)	0.547	2
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.547	2
UniProt:Q61160	1	Fadd [cytosol] (R-MMU-54639)	0.508	2

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