Reactome | THBS3 [extracellular region]

THBS3 [extracellular region]

Stable Identifier

R-HSA-66522

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Thrombospondin 3 precursor

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PDGF (Homo sapiens)
    - PDGF binds to extracellular matrix proteins (Homo sapiens)
      - Extracellular matrix ligands [extracellular region] (Homo sapiens)
        
        Thrombospondin [extracellular region] (Homo sapiens)
        
        THBS3 [extracellular region] (Homo sapiens)
      - PDGF A and B chains:ECM complex [extracellular region] (Homo sapiens)
        
        Extracellular matrix ligands [extracellular region] (Homo sapiens)
        
        Thrombospondin [extracellular region] (Homo sapiens)
        
        THBS3 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49746 THBS3

Gene Names

THBS3, TSP3

Chain

signal peptide:1-22, chain:23-956

Reference Genes

BioGPS Gene:7059 THBS3

COSMIC (genes):THBS3 THBS3

CTD Gene:7059 THBS3

dbSNP Gene:7059 THBS3

ENSEMBL:ENSG00000169231 THBS3

ENSEMBL_homo_sapiens_GENE:ENSG00000169231.13 THBS3

HGNC:11787 THBS3

KEGG Gene (Homo sapiens):7059 THBS3

Monarch:7059 THBS3

NCBI Gene:7059 THBS3

OMIM:188062 THBS3

UCSC:P49746 THBS3

Reference Transcript

Other Identifiers

11722043_a_at

11748351_a_at

16693996

209561_PM_at

209561_at

2437153

2437154

2437155

2437158

2437160

2437162

2437163

2437166

2437167

2437168

2437173

2437175

2437176

2437177

2437178

2437180

2437182

2437183

2437185

2437187

2437189

2437192

2437193

2437198

2437199

2437201

2437202

32670_at

7059

7920664

A_23_P201047

GE61266

GO:0003417

GO:0005198

GO:0005201

GO:0005509

GO:0005515

GO:0005576

GO:0007155

GO:0007160

GO:0008201

GO:0030312

GO:0031012

GO:0043931

GO:0048471

GO:0048856

GO:0060346

GO:0062023

HMNXSV003043508

HMNXSV003053858

ILMN_1804663

L38969_at

PH_hs_0010130

TC01003305.hg

g886298_3p_at

Participates

as a member of

Thrombospondin [extracellular region] (Homo sapiens)

Inferred To

THBS3 [extracellular region] (Bos taurus)

THBS3 [extracellular region] (Canis familiaris)

THBS3 [extracellular region] (Sus scrofa)

Tsp [extracellular region] (Drosophila melanogaster)

thbs3a [extracellular region] (Danio rerio)

Thbs3 [extracellular region] (Mus musculus)

Thbs3 [extracellular region] (Rattus norvegicus)

thbs3 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001239537.1, NP_001239536.1, NP_009043.1

OpenTargets

ENSG00000169231

HPA

ENSG00000169231-THBS3

GeneCards

P49746

Ensembl

ENSP00000357362, ENSG00000169231, ENST00000368378, ENST00000457183, ENSP00000392207

PRO

P49746

Pharos - Targets

P49746

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36957 DLST	4	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3