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WRN [nucleoplasm]
Stable Identifier
R-HSA-67387
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Werner syndrome helicase
Locations in the PathwayBrowser for interactor UniProt:P13010 XRCC5
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Processive synthesis on the C-strand of the telomere (Homo sapiens)
Removal of the Flap Intermediate from the C-strand (Homo sapiens)
Removal of remaining Flap from the C-strand (Homo sapiens)
WRN [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 (Homo sapiens)
WRN [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14191 WRN
Gene Names
WRN, RECQ3, RECQL2
Chain
initiator methionine:, chain:2-1432
Reference Genes
BioGPS Gene:7486 WRN
COSMIC (genes):WRN WRN
CTD Gene:7486 WRN
dbSNP Gene:7486 WRN
ENSEMBL:ENSG00000165392 WRN
ENSEMBL_homo_sapiens_GENE:ENSG00000165392.11 WRN
HGNC:12791 WRN
KEGG Gene (Homo sapiens):7486 WRN
Monarch:7486 WRN
NCBI Gene:7486 WRN
OMIM:604611 WRN
UCSC:Q14191 WRN
Reference Transcript
RefSeq:NM_000553.4 WRN
Other Identifiers
11732584_a_at
17067632
17067672
205667_PM_at
205667_at
3092664
3092666
3092667
3092668
3092670
3092671
3092672
3092674
3092681
3092683
3092684
3092685
3092688
3092690
3092691
3092692
3092693
3092694
3092695
3092696
3092697
3092699
3092700
3092702
3092705
3092706
3092713
3092716
3092717
3092718
3092719
3092720
3092721
3092722
3092725
3092726
3092727
3092731
3092732
3092733
3092734
3092735
3092736
3092738
38136_at
47690_at
7486
8145702
A_14_P117520
A_14_P123326
A_14_P137673
A_19_P00809110
A_21_P0005679
A_23_P250813
GE57795
GO:0000166
GO:0000287
GO:0000400
GO:0000403
GO:0000405
GO:0000723
GO:0000724
GO:0000731
GO:0000781
GO:0003676
GO:0003677
GO:0003678
GO:0003682
GO:0003824
GO:0004386
GO:0004518
GO:0004527
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006139
GO:0006259
GO:0006260
GO:0006268
GO:0006281
GO:0006284
GO:0006302
GO:0006310
GO:0006974
GO:0006979
GO:0008152
GO:0008340
GO:0008408
GO:0009267
GO:0009378
GO:0010225
GO:0016607
GO:0016787
GO:0016887
GO:0030145
GO:0031297
GO:0032200
GO:0032201
GO:0032392
GO:0032405
GO:0032508
GO:0040009
GO:0042803
GO:0043138
GO:0043226
GO:0044237
GO:0044806
GO:0044877
GO:0046872
GO:0051345
GO:0051880
GO:0061749
GO:0061820
GO:0061821
GO:0061849
GO:0070337
GO:0071480
GO:0090398
GO:0090399
GO:0090656
GO:0098530
GO:0140097
GO:0140657
GO:1902570
GO:1905773
HMNXSV003031434
HMNXSV003031934
ILMN_1679881
L76937_rna1_at
PH_hs_0026827
TC08000246.hg
TC08001869.hg
g5739523_3p_at
p24130
Participates
as an input of
CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 (Homo sapiens)
as a member of
BLM,WRN [nucleoplasm] (Homo sapiens)
as a candidate of
BLM,WRN [nucleoplasm] (Homo sapiens)
as a component of
DNA2:WRN [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
Removal of remaining Flap from the C-strand
(Homo sapiens)
Other forms of this molecule
monoSUMO1-K356,K496,K898-WRN [nucleoplasm]
Inferred To
WRN [nucleoplasm]
(Bos taurus)
WRN [nucleoplasm]
(Caenorhabditis elegans)
WRN [nucleoplasm]
(Canis familiaris)
WRN [nucleoplasm]
(Gallus gallus)
WRN [nucleoplasm]
(Mus musculus)
WRN [nucleoplasm]
(Sus scrofa)
Wrn [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_000544.2
Guide to Pharmacology - Targets
3259
OpenTargets
ENSG00000165392
ZINC - Substances
WRN_HUMAN
ZINC target
Q14191
PRO
Q14191
PDB
2FBT
,
8PFO
,
6TYV
,
8YLE
,
2DGZ
,
2FBV
,
8PFP
,
2FBX
,
2FC0
,
2E1E
,
3AAF
,
7XUT
,
2AXL
,
2E1F
,
6YHR
,
2FBY
,
8PFL
GeneCards
Q14191
HPA
ENSG00000165392-WRN
Ensembl
ENST00000298139
,
ENSG00000165392
,
ENSP00000298139
Pharos - Targets
Q14191
Orphanet
15730
ZINC - Predictions - Purchasable
WRN_HUMAN
HMDB Protein
HMDBP08834
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P12956 XRCC6
5
XRCC6 [secretory granule lumen]
(R-HSA-6801312)
XRCC6 [extracellular region]
(R-HSA-6806444)
XRCC6 [ficolin-1-rich granule lumen]
(R-HSA-6801300)
XRCC6 [cytosol]
(R-HSA-3134813)
XRCC6 [nucleoplasm]
(R-HSA-58272)
0.897
10
UniProt:P13010 XRCC5
4
XRCC5 [extracellular region]
(R-HSA-6806530)
XRCC5 [secretory granule lumen]
(R-HSA-6801297)
XRCC5 [cytosol]
(R-HSA-3134849)
XRCC5 [nucleoplasm]
(R-HSA-58274)
0.853
9
UniProt:P39748 FEN1
1
FEN1 [nucleoplasm]
(R-HSA-54745)
0.822
9
UniProt:P27694 RPA1
2
polySUMO2,3-K449,K577-RPA1 [nucleoplasm]
(R-HSA-4551644)
RPA1 [nucleoplasm]
(R-HSA-68461)
0.818
9
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.761
9
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.739
8
UniProt:P43351 RAD52
3
monoSUMO1-K411,K412,K414-RAD52 [nucleoplasm]
(R-HSA-4568909)
RAD52 [nucleoplasm]
(R-HSA-62639)
p-Y104-RAD52 [nucleoplasm]
(R-HSA-5686588)
0.675
9
UniProt:P16104 H2AFX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
0.667
6
UniProt:Q15554 TERF2
2
TERF2 [nucleoplasm]
(R-HSA-174895)
p-S365-TERF2 [nucleoplasm]
(R-HSA-9686530)
0.655
8
UniProt:P54132 BLM
2
4SUMO2,3-BLM [nucleoplasm]
(R-HSA-4568883)
BLM [nucleoplasm]
(R-HSA-174881)
0.655
9
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.647
5
UniProt:P35244 RPA3
1
RPA3 [nucleoplasm]
(R-HSA-68459)
0.508
2
UniProt:P36405 ARL3
1
ARL3 [cilium]
(R-HSA-5618182)
0.508
2
UniProt:Q9UGP5 POLL
1
POLL [nucleoplasm]
(R-HSA-5687352)
0.508
2
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.499
3
UniProt:P15927 RPA2
2
RPA2 [nucleoplasm]
(R-HSA-68457)
p-S33-RPA2 [nucleoplasm]
(R-HSA-5685148)
0.491
3
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