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XAB2 [nucleoplasm]
Stable Identifier
R-HSA-67411
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
XPA-binding protein 2, HCNP protein, PP3898
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
ERCC5 and RPA bind TC-NER site (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HCS7 XAB2
Gene Names
XAB2, HCNP, KIAA1177, SYF1, PP3898
Chain
chain:1-855
Reference Genes
BioGPS Gene:56949 XAB2
COSMIC (genes):XAB2 XAB2
CTD Gene:56949 XAB2
dbSNP Gene:56949 XAB2
ENSEMBL:ENSG00000076924 XAB2
HGNC:14089 XAB2
KEGG:hsa:56949 XAB2
Monarch:56949 XAB2
NCBI Gene:56949 XAB2
OMIM:610850 XAB2
UCSC:Q9HCS7 XAB2
Reference Transcript
RefSeq:NM_020196.2 XAB2
Other Identifiers
11757909_a_at
16867948
218110_PM_at
218110_at
3848440
3848441
3848442
3848443
3848444
3848445
3848446
3848447
3848448
3848449
3848450
3848451
3848452
3848453
3848454
3848455
3848456
3848458
3848461
3848464
3848465
3848466
3848467
3848468
3848469
3848471
3848472
3848473
3848474
3848475
3848476
3848477
3848478
3848479
47620_at
56949
8033392
A_23_P142013
A_24_P2093
A_24_P390974
GE53813
GO:0000349
GO:0000398
GO:0000974
GO:0001824
GO:0005515
GO:0005634
GO:0005654
GO:0005681
GO:0006281
GO:0006283
GO:0006351
GO:0006396
GO:0006397
GO:0008380
GO:0016020
GO:0016071
GO:0043226
GO:0043231
GO:0048856
GO:0065003
GO:0071007
GO:0071013
GO:0071014
HMNXSV003053797
ILMN_1771057
PH_hs_0001015
TC19001114.hg
g9910259_3p_at
Participates
as a component of
XAB2 complex [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
Inferred To
fand [nucleoplasm]
(Drosophila melanogaster)
syf-1 [nucleoplasm]
(Caenorhabditis elegans)
SYF1 [nucleoplasm]
(Saccharomyces cerevisiae)
Xab2 [nucleoplasm]
(Mus musculus)
Xab2 [nucleoplasm]
(Rattus norvegicus)
xab2 [nucleoplasm]
(Danio rerio)
xab2 [nucleoplasm]
(Dictyostelium discoideum)
xab2 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of XAB2 [nucleoplasm]
(Gallus gallus)
XAB2 [nucleoplasm]
(Bos taurus)
XAB2 [nucleoplasm]
(Canis familiaris)
XAB2 [nucleoplasm]
(Plasmodium falciparum)
XAB2 [nucleoplasm]
(Sus scrofa)
cwf3 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
OpenTargets
ENSG00000076924
ENSEMBL
ENSP00000351137
,
ENSG00000076924
,
ENST00000358368
HPA
ENSG00000076924-XAB2
GeneCards
XAB2
PRO
Q9HCS7
Pharos - Targets
Q9HCS7
GlyGen
Q9HCS7
PDB
6ID0
,
6FF7
,
8I0V
,
8I0U
,
9FMD
,
8I0T
,
6ICZ
,
5XJC
,
8CH6
,
8I0S
,
7ABI
,
8I0R
,
8I0P
,
7W5B
,
5Z57
,
5Z56
,
8RO2
,
5YZG
,
7W5A
,
6QDV
,
7W59
,
7A5P
,
8I0W
,
5MQF
,
6ID1
,
8C6J
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09661 SNRPA1
1
SNRPA1 [nucleoplasm]
(R-HSA-71958)
0.688
5
UniProt:P62306 SNRPF
2
SNRPF [cytosol]
(R-HSA-191852)
SNRPF [nucleoplasm]
(R-HSA-71907)
0.643
4
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.632
4
UniProt:Q9CSN1 Snw1
1
Snw1 [nucleoplasm]
(R-MMU-2065315)
0.564
2
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q86VM9 ZC3H18
1
ZC3H18 [nucleoplasm]
(R-HSA-9930040)
0.527
2
UniProt:P62304 SNRPE
2
SNRPE [cytosol]
(R-HSA-191782)
SNRPE [nucleoplasm]
(R-HSA-71905)
0.527
4
UniProt:Q14562 DHX8
1
DHX8 [nucleoplasm]
(R-HSA-5688092)
0.527
3
UniProt:P14678 SNRPB
4
2xMe-SNRPB [cytosol]
(R-HSA-192218)
SNRPB [cytosol]
(R-HSA-191798)
Me2-R108,R112-SNRPB [nucleoplasm]
(R-HSA-192213)
SNRPB [nucleoplasm]
(R-HSA-71896)
0.527
3
UniProt:O95926 SYF2
1
SYF2 [nucleoplasm]
(R-HSA-8867884)
0.527
3
UniProt:Q9BW85 YJU2
1
YJU2 [nucleoplasm]
(R-HSA-9770430)
0.527
2
UniProt:O60231 DHX16
1
DHX16 [nucleoplasm]
(R-HSA-8850837)
0.508
2
UniProt:Q13123 IK
1
IK [nucleoplasm]
(R-HSA-9770239)
0.508
2
UniProt:P23025 XPA
1
XPA [nucleoplasm]
(R-HSA-67437)
0.508
2
UniProt:Q03468 ERCC6
2
Ub-ERCC6 [nucleoplasm]
(R-HSA-6781853)
ERCC6 [nucleoplasm]
(R-HSA-54429)
0.499
2
UniProt:Q16629 SRSF7
1
SRSF7 [nucleoplasm]
(R-HSA-72029)
0.483
2
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