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XRCC1 [nucleoplasm]
Stable Identifier
R-HSA-67455
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA-repair protein XRCC1
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
Resolution of AP sites via the single-nucleotide replacement pathway (Homo sapiens)
Dissociation of LIG3:XRCC1 complex from the BER site (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Homo sapiens)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
Resynthesis of excised residue by POLB (Homo sapiens)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
XRCC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18887 XRCC1
Gene Names
XRCC1
Chain
chain:1-633
Reference Genes
BioGPS Gene:7515 XRCC1
COSMIC (genes):XRCC1 XRCC1
CTD Gene:7515 XRCC1
dbSNP Gene:7515 XRCC1
ENSEMBL:ENSG00000073050 XRCC1
HGNC:12828 XRCC1
KEGG:hsa:7515 XRCC1
Monarch:7515 XRCC1
NCBI Gene:7515 XRCC1
OMIM:194360 XRCC1
UCSC:P18887 XRCC1
Reference Transcript
RefSeq:NM_006297.2 XRCC1
Other Identifiers
11725480_s_at
11745748_s_at
160033_s_at
16873015
1829_at
203655_PM_at
203655_at
3864448
3864449
3864450
3864452
3864454
3864455
3864456
3864457
3864458
3864462
3864463
3864464
3864465
3864466
3864467
3864468
3864469
3864471
3864472
3864473
3864474
3864475
3864478
3864479
3864482
7515
8037331
A_23_P153692
GE57951
GO:0000012
GO:0000781
GO:0000785
GO:0001666
GO:0003677
GO:0003684
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006281
GO:0006284
GO:0006303
GO:0006310
GO:0006974
GO:0009410
GO:0010836
GO:0016787
GO:0019899
GO:0021587
GO:0021766
GO:0032200
GO:0032356
GO:0033194
GO:0043226
GO:0048856
GO:0050877
GO:0050882
GO:0061819
GO:0070522
GO:0072572
GO:0090734
GO:0140097
GO:0160002
GO:1903518
GO:1904877
GO:1905765
GO:1990414
GO:1990599
HMNXSV003052338
ILMN_1751743
M36089_at
PH_hs_0027195
TC19001589.hg
g5454171_3p_at
Participates
as a component of
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Inferred To
XRCC1 [nucleoplasm]
(Bos taurus)
XRCC1 [nucleoplasm]
(Canis familiaris)
XRCC1 [nucleoplasm]
(Drosophila melanogaster)
XRCC1 [nucleoplasm]
(Gallus gallus)
XRCC1 [nucleoplasm]
(Sus scrofa)
xrcc1 [nucleoplasm]
(Danio rerio)
xrcc1 [nucleoplasm]
(Dictyostelium discoideum)
xrcc1 [nucleoplasm]
(Xenopus tropicalis)
Xrcc1 [nucleoplasm]
(Mus musculus)
Xrcc1 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_006288.2
ENSEMBL
ENSP00000262887
,
ENST00000262887
OpenTargets
ENSG00000073050
HPA
ENSG00000073050-XRCC1
PRO
P18887
Pharos - Targets
P18887
GlyGen
P18887
PDB
2W3O
,
5W7X
,
2D8M
,
3LQC
,
1CDZ
,
5E6Q
,
5W7Y
,
6WH2
,
6WH1
,
3K75
,
3K77
,
1XNT
,
1XNA
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.832
8
UniProt:P09874 PARP1
4
PARP1 [nucleoplasm]
(R-HSA-201568)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
0.744
7
UniProt:P06746 POLB
2
POLB [nucleoplasm]
(R-HSA-53845)
PolyUb-POLB [nucleoplasm]
(R-HSA-6783152)
0.738
5
UniProt:P06766
2
POLB [nucleoplasm]
(R-RNO-53845)
PolyUb-POLB [nucleoplasm]
(R-RNO-6783152)
0.719
4
UniProt:O96017 CHEK2
3
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
CHEK2 [nucleoplasm]
(R-HSA-113824)
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
0.645
8
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.491
3
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