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RNA Polymerase II Pre-transcription Events
Stable Identifier
R-HSA-674695
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
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For initiation, Pol II assembles with the general transcription factors TFIIB, TFIID, TFIIE, TFIIF and TFIIH, which are collectively known as the general transcription factors, at promoter DNA to form the pre-initiation complex (PIC). Until the nascent transcript is about 15 nucleotides long, the early transcribing complex is functionally unstable. In the beginning, short RNAs are frequently released and Pol II has to restart transcription (abortive cycling). There is a decline in the level of abortive transcription when the RNA reaches a length of about four nucleotides, and this transition is termed escape commitment
Literature References
PubMed ID
Title
Journal
Year
14969722
Structure and function of RNA polymerase II
Cramer, P
Adv. Protein Chem.
2004
Participants
Events
Abortive initiation after formation of the first phosphodiester bond
(Homo sapiens)
Abortive Initiation After Second Transition
(Homo sapiens)
Abortive Initiation Before Second Transition
(Homo sapiens)
Formation of DSIF complex
(Homo sapiens)
Formation of Elongin BC complex
(Homo sapiens)
Formation of FACT complex
(Homo sapiens)
Formation of NELF complex
(Homo sapiens)
Formation of P-TEFb complex
(Homo sapiens)
Formation of Elongin complex
(Homo sapiens)
Resumption of elongation after recovery from pausing
(Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
(Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
(Homo sapiens)
TFIIS-mediated recovery of elongation from arrest
(Homo sapiens)
Abortive termination of early transcription elongation by DSIF:NELF
(Homo sapiens)
Abortive termination of elongation after arrest
(Homo sapiens)
Elongating transcript encounters a lesion in the template
(Homo sapiens)
Fall Back to Closed Pre-initiation Complex
(Homo sapiens)
Participates
as an event of
RNA Polymerase II Transcription (Homo sapiens)
Orthologous Events
RNA Polymerase II Pre-transcription Events (Bos taurus)
RNA Polymerase II Pre-transcription Events (Caenorhabditis elegans)
RNA Polymerase II Pre-transcription Events (Canis familiaris)
RNA Polymerase II Pre-transcription Events (Danio rerio)
RNA Polymerase II Pre-transcription Events (Dictyostelium discoideum)
RNA Polymerase II Pre-transcription Events (Drosophila melanogaster)
RNA Polymerase II Pre-transcription Events (Gallus gallus)
RNA Polymerase II Pre-transcription Events (Mus musculus)
RNA Polymerase II Pre-transcription Events (Plasmodium falciparum)
RNA Polymerase II Pre-transcription Events (Rattus norvegicus)
RNA Polymerase II Pre-transcription Events (Saccharomyces cerevisiae)
RNA Polymerase II Pre-transcription Events (Schizosaccharomyces pombe)
RNA Polymerase II Pre-transcription Events (Sus scrofa)
RNA Polymerase II Pre-transcription Events (Xenopus tropicalis)
Created
Gillespie, ME (2010-05-05)
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