Reactome | ERCC8 (CSA) binds stalled RNA Pol II

ERCC8 (CSA) binds stalled RNA Pol II

Stable Identifier

R-HSA-6781833

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Cockayne syndrome protein A (ERCC8, also known as CSA) is recruited to a stalled RNA polymerase II complex (RNA Pol II) at a site of DNA damage in an ERCC6 (CSB) dependent manner (Kamiuchi et al. 2002; van der Weegen et al. 2020). ERCC8 is part of an ubiquitin ligase complex that, in addition to ERCC8, also contains DDB1, CUL4 (CUL4A or CUL4B) and RBX1 (Groisman et al. 2003). The COP9 signalosome complex prevents the ubiquitin ligase activity of the ERCC8:DDB1:CUL4:RBX1 at the early steps after DNA damage induction (Groisman et al. 2003, Fischer et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
22118460	The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation Lingaraju, GM, Gut, H, Yasuda, T, Iwai, S, Thomä, NH, Sugasawa, K, Scrima, A, Fischer, ES, Cavadini, S, Böhm, K, Hanaoka, F, Wakasugi, M, Faty, M, Matsumoto, S	Cell	2011
32355176	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II González-Prieto, R, Golan-Berman, H, Adar, S, van den Heuvel, D, Luijsterburg, MS, van der Weegen, Y, Apelt, K, Vertegaal, ACO, Heilbrun, EE, Goedhart, J, Walter, JC, Mevissen, TET	Nat Commun	2020
12732143	The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage Drapkin, R, Kuraoka, I, Polanowska, J, Kisselev, AF, Tanaka, K, Saijo, M, Sawada, J, Groisman, R, Nakatani, Y	Cell	2003
11782547	Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair Kamiuchi, S, Tanaka, K, de Jager, M, Saijo, M, Citterio, E, Hoeijmakers, JH	Proc Natl Acad Sci U S A	2002