ZRANB1 binds APC

Stable Identifier
R-HSA-6781905
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ZRANB1 binds APC
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ZRANB1 (Trabid) binds and cleaves K63-linked ubiquitin chains. It is required for efficient TCF-mediated transcription in cells with high Wnt pathway activity, including colorectal cancer cell lines. ZRANB1 can deubiquitinate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription (Tran et al. 2008).
Literature References
PubMed ID Title Journal Year
18281465 Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

Tran, H, Schwarz-Romond, T, Bienz, M, Hamada, F

Genes Dev. 2008
Participants
Input
Output
Participates
as an event of
Orthologous Events
ZRANB1 binds APC (Bos taurus)
ZRANB1 binds APC (Canis familiaris)
ZRANB1 binds APC (Drosophila melanogaster)
ZRANB1 binds APC (Gallus gallus)
ZRANB1 binds APC (Mus musculus)
ZRANB1 binds APC (Rattus norvegicus)
ZRANB1 binds APC (Sus scrofa)
ZRANB1 binds APC (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-03)
Cite Us!