Reactome | FAF2 [cytosol]

FAF2 [cytosol]

Stable Identifier

R-HSA-6781921

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

FAS-associated factor 2, FAF2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOA GTPase cycle (Homo sapiens)
        
        RHOA binds effectors at the plasma membrane (Homo sapiens)
        
        RHOA plasma membrane effectors [cytosol] (Homo sapiens)
        
        FAF2 [cytosol] (Homo sapiens)
        
        RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Homo sapiens)
        
        RHOA plasma membrane effectors [cytosol] (Homo sapiens)
        
        FAF2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96CS3 FAF2

Gene Names

FAF2, ETEA, KIAA0887, UBXD8, UBXN3B

Chain

initiator methionine:, chain:2-445

Reference Genes

BioGPS Gene:23197 FAF2

COSMIC (genes):FAF2 FAF2

CTD Gene:23197 FAF2

dbSNP Gene:23197 FAF2

ENSEMBL:ENSG00000113194 FAF2

ENSEMBL_homo_sapiens_GENE:ENSG00000113194.13 FAF2

HGNC:24666 FAF2

KEGG Gene (Homo sapiens):23197 FAF2

Monarch:23197 FAF2

NCBI Gene:23197 FAF2

OMIM:616935 FAF2

UCSC:Q96CS3 FAF2

Reference Transcript

RefSeq:NM_014613.2 FAF2

Other Identifiers

11716000_a_at

11716001_at

11716002_at

11716003_a_at

11716004_at

11753411_a_at

16992814

212106_PM_at

212106_at

212108_PM_at

212108_at

23197

2842575

2842576

2842585

2842586

2842587

2842589

2842594

2842597

2842598

2842601

2842605

2842606

2842610

2842611

2842612

2842613

2842614

37030_at

8110169

A_14_P119601

A_23_P156109

A_24_P294719

GE53562

GO:0005515

GO:0005576

GO:0005737

GO:0005764

GO:0005773

GO:0005783

GO:0005811

GO:0006886

GO:0006986

GO:0030163

GO:0030433

GO:0030674

GO:0030970

GO:0031410

GO:0031625

GO:0034098

GO:0034389

GO:0035473

GO:0035578

GO:0035617

GO:0043130

GO:0043161

GO:0043226

GO:0055102

GO:0060090

GO:0098772

HMNXSV003046384

Hs.76591.0.S1_3p_at

Hs.76591.0.S2_3p_at

ILMN_1670472

PH_hs_0004422

TC05001000.hg

Participates

as a candidate of

RHOA plasma membrane effectors [cytosol] (Homo sapiens)

Other forms of this molecule

FAF2 [extracellular region]

FAF2 [azurophil granule lumen]

Inferred To

faf2 [cytosol] (Danio rerio)

faf2 [cytosol] (Xenopus tropicalis)

UBX2 [cytosol] (Saccharomyces cerevisiae)

FAF2 [cytosol] (Bos taurus)

FAF2 [cytosol] (Caenorhabditis elegans)

FAF2 [cytosol] (Canis familiaris)

FAF2 [cytosol] (Gallus gallus)

FAF2 [cytosol] (Sus scrofa)

ucp10 [cytosol] (Schizosaccharomyces pombe)

Faf2 [cytosol] (Drosophila melanogaster)

Faf2 [cytosol] (Mus musculus)

Faf2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_055428.1

OpenTargets

ENSG00000113194

GeneCards

Q96CS3

HPA

ENSG00000113194-FAF2

Ensembl

ENSP00000261942, ENST00000261942, ENSG00000113194

PRO

Q96CS3

Pharos - Targets

Q96CS3

PDB

2DAM

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.826	14
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	17
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.643	4
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.643	4
UniProt:Q96JH7 VCPIP1	2	p-S131-VCPIP1 [endoplasmic reticulum lumen] (R-HSA-8940104) VCPIP1 [endoplasmic reticulum lumen] (R-HSA-8940103)	0.564	2
UniProt:Q9UBV2 SEL1L	1	SEL1L [endoplasmic reticulum membrane] (R-HSA-1911545)	0.527	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.527	2
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	2
UniProt:Q9NWR8 MCUB	1	MCUB [mitochondrial inner membrane] (R-HSA-8949153)	0.527	2
UniProt:P31350 RRM2	1	RRM2 [cytosol] (R-HSA-73639)	0.527	2
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.527	2
UniProt:Q14534 SQLE	1	SQLE [endoplasmic reticulum membrane] (R-HSA-191395)	0.527	2

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